Delving into the Latest Updates on Amphihevir with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

NS4B

Mechanism

NS4B inhibitors(Nonstructural protein 4B inhibitors)

Therapeutic Areas

Infectious DiseasesDigestive System Disorders

Active Indication

Chronic hepatitis C genotype 1Hepatitis C

Inactive Indication-

Originator Organization

Sichuan University

Active Organization

Sichuan University

Changzhou Yinsheng Pharmaceutical Co., Ltd

China Pharmaceutical University

Inactive Organization-

Drug Highest PhasePhase 1

First Approval Date-

RegulationSpecial Review Project (CN)

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To evaluate the drug-drug interactions between anfecivir soft capsules and fobitasvir tablets, as well as the pharmacokinetic properties and tolerability of anfecivir soft capsules and fobitasvir tablets in healthy subjects, and to provide a basis for the design of dosing regimens in subsequent clinical trials.

Start Date-

Sponsor / Collaborator

Changzhou Yinsheng Pharmaceutical Co., Ltd

[+1]

CTR20170085 / Not yet recruitingPhase 1

安非合韦软胶囊在健康受试者中的多剂量单次、多次给药的耐受性、药代动力学Ⅰ期临床试验

[Translation] Phase I clinical trial of tolerability and pharmacokinetics of multiple single and multiple doses of Anfeihewei soft capsules in healthy subjects

评价安非合韦软胶囊在健康受试者中多剂量、单次、多次给药耐受性研究；评价安非合韦软胶囊在健康受试者中多剂量、单次、多次给药药代动力学研究；评价安非合韦软胶囊药物代谢转化研究；评价食物对安非合韦软胶囊药代动力学的影响。

[Translation]

To evaluate the tolerance of multiple-dose, single-dose and multiple-dose anfecivir soft capsules in healthy subjects; To evaluate the pharmacokinetic study of multiple-dose, single-dose and multiple-dose anfecivir soft capsules in healthy subjects; To evaluate the drug metabolism and transformation study of anfecivir soft capsules; To evaluate the effect of food on the pharmacokinetics of anfecivir soft capsules.

Start Date-

Sponsor / Collaborator

Changzhou Yinsheng Pharmaceutical Co., Ltd

[+1]

CTR20170632 / Not yet recruitingPhase 1

安非合韦软胶囊在基因I型慢性丙肝患者中的多剂量单次、多次给药的耐受性、药代动力学和药效学Ⅰ期临床试验

[Translation] Phase I clinical trial of tolerability, pharmacokinetics and pharmacodynamics of multiple single and multiple administrations of Anfeihewei soft capsules in patients with chronic hepatitis C genotype I

评价安非合韦软胶囊在基因1型慢性丙肝患者中多剂量、单次、多次给药耐受性研究；评价安非合韦软胶囊在基因1型慢性丙肝患者中多剂量、单次、多次给药药代动力学研究；评价安非合韦软胶囊在基因1型慢性丙肝患者中多剂量、单次、多次给药的抗病毒活性。

[Translation]

To evaluate the tolerance of multiple-dose, single-dose and multiple-dose Anfeihevir soft capsules in patients with chronic hepatitis C genotype 1; To evaluate the pharmacokinetic study of multiple-dose, single-dose and multiple-dose Anfeihevir soft capsules in patients with chronic hepatitis C genotype 1; To evaluate the antiviral activity of multiple-dose, single-dose and multiple-dose Anfeihevir soft capsules in patients with chronic hepatitis C genotype 1.

Start Date-

Sponsor / Collaborator

Changzhou Yinsheng Pharmaceutical Co., Ltd

[+1]

100 Clinical Results associated with Amphihevir

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100 Translational Medicine associated with Amphihevir

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100 Patents (Medical) associated with Amphihevir

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1

Literatures (Medical) associated with Amphihevir

01 Dec 2019·Antimicrobial Agents and ChemotherapyQ2 · MEDICINE

Preclinical Evaluation of Amphihevir, a First-in-Class Clinical Hepatitis C Virus NS4B Inhibitor

Q2 · MEDICINE

Article

Author: Wang, Lichun ; Zhang, Yang ; Fu, Zhifei ; Wang, Jianfei ; Wang, Ningyu ; Yu, Luoting ; Tao, Xin ; Chen, Shuhui ; Gu, Zhengxian

Amphihevir, a benzofuran derivative, is the first reported hepatitis C virus (HCV) nonstructural protein 4B (NS4B) inhibitor that has advanced to clinical trials (currently in phase Ib trial [CTR20170632]). Here, we report the results of a preclinical study of its potency, toxicity, selectivity, drug metabolism and pharmacokinetics (DMPK), and safety profiles.

100 Deals associated with Amphihevir

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Chronic hepatitis C genotype 1	Phase 1	CN	Changzhou Yinsheng Pharmaceutical Co., Ltd	14 Jul 2017
Chronic hepatitis C genotype 1	Phase 1	CN	Sichuan University	14 Jul 2017
Hepatitis C	Phase 1	CN	China Pharmaceutical University	-