Delving into the Latest Updates on Amphihevir with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

NS4B

Mechanism

NS4B inhibitors(Nonstructural protein 4B inhibitors)

Therapeutic Areas

Infectious DiseasesDigestive System Disorders

Active Indication

Chronic hepatitis C genotype 1Hepatitis C

Inactive Indication-

Originator Organization

Sichuan University

Active Organization

Sichuan University

Changzhou Yinsheng Pharmaceutical Co., Ltd

China Pharmaceutical University

Inactive Organization-

Drug Highest PhasePhase 1

First Approval Date-

RegulationSpecial Review Project (CN)

Login to view timeline

To evaluate the drug-drug interactions between anfecivir soft capsules and fobitasvir tablets, as well as the pharmacokinetic properties and tolerability of anfecivir soft capsules and fobitasvir tablets in healthy subjects, and to provide a basis for the design of dosing regimens in subsequent clinical trials.

Start Date-

Sponsor / Collaborator

Changzhou Yinsheng Pharmaceutical Co., Ltd

[+1]

CTR20170085 / Not yet recruitingPhase 1

安非合韦软胶囊在健康受试者中的多剂量单次、多次给药的耐受性、药代动力学Ⅰ期临床试验

[Translation] Phase I clinical trial of tolerability and pharmacokinetics of multiple single and multiple doses of Anfeihewei soft capsules in healthy subjects

评价安非合韦软胶囊在健康受试者中多剂量、单次、多次给药耐受性研究；评价安非合韦软胶囊在健康受试者中多剂量、单次、多次给药药代动力学研究；评价安非合韦软胶囊药物代谢转化研究；评价食物对安非合韦软胶囊药代动力学的影响。

[Translation]

To evaluate the tolerance of multiple-dose, single-dose and multiple-dose anfecivir soft capsules in healthy subjects; To evaluate the pharmacokinetic study of multiple-dose, single-dose and multiple-dose anfecivir soft capsules in healthy subjects; To evaluate the drug metabolism and transformation study of anfecivir soft capsules; To evaluate the effect of food on the pharmacokinetics of anfecivir soft capsules.

Start Date-

Sponsor / Collaborator

Changzhou Yinsheng Pharmaceutical Co., Ltd

[+1]

CTR20170632 / Not yet recruitingPhase 1

安非合韦软胶囊在基因I型慢性丙肝患者中的多剂量单次、多次给药的耐受性、药代动力学和药效学Ⅰ期临床试验

[Translation] Phase I clinical trial of tolerability, pharmacokinetics and pharmacodynamics of multiple single and multiple administrations of Anfeihewei soft capsules in patients with chronic hepatitis C genotype I

评价安非合韦软胶囊在基因1型慢性丙肝患者中多剂量、单次、多次给药耐受性研究；评价安非合韦软胶囊在基因1型慢性丙肝患者中多剂量、单次、多次给药药代动力学研究；评价安非合韦软胶囊在基因1型慢性丙肝患者中多剂量、单次、多次给药的抗病毒活性。

[Translation]

To evaluate the tolerance of multiple-dose, single-dose and multiple-dose Anfeihevir soft capsules in patients with chronic hepatitis C genotype 1; To evaluate the pharmacokinetic study of multiple-dose, single-dose and multiple-dose Anfeihevir soft capsules in patients with chronic hepatitis C genotype 1; To evaluate the antiviral activity of multiple-dose, single-dose and multiple-dose Anfeihevir soft capsules in patients with chronic hepatitis C genotype 1.

Start Date-

Sponsor / Collaborator

Changzhou Yinsheng Pharmaceutical Co., Ltd

[+1]

100 Clinical Results associated with Amphihevir

Login to view more data

100 Translational Medicine associated with Amphihevir

Login to view more data

100 Patents (Medical) associated with Amphihevir

Login to view more data

1

Literatures (Medical) associated with Amphihevir

01 Dec 2019·Antimicrobial Agents and ChemotherapyQ2 · MEDICINE

Preclinical Evaluation of Amphihevir, a First-in-Class Clinical Hepatitis C Virus NS4B Inhibitor

Q2 · MEDICINE

Article

Author: Wang, Lichun ; Zhang, Yang ; Fu, Zhifei ; Wang, Ningyu ; Wang, Jianfei ; Yu, Luoting ; Tao, Xin ; Chen, Shuhui ; Gu, Zhengxian

Amphihevir, a benzofuran derivative, is the first reported hepatitis C virus (HCV) nonstructural protein 4B (NS4B) inhibitor that has advanced to clinical trials (currently in phase Ib trial [CTR20170632]). Here, we report the results of a preclinical study of its potency, toxicity, selectivity, drug metabolism and pharmacokinetics (DMPK), and safety profiles.

100 Deals associated with Amphihevir

Login to view more data

R&D Status

10 top R&D records.

Login

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Chronic hepatitis C genotype 1	Phase 1	CN	Changzhou Yinsheng Pharmaceutical Co., Ltd	14 Jul 2017
Chronic hepatitis C genotype 1	Phase 1	CN	Sichuan University	14 Jul 2017
Hepatitis C	Phase 1	CN	China Pharmaceutical University	-