Delving into the Latest Updates on RK-701 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target

EHMT2

Mechanism

EHMT2 inhibitors(euchromatic histone lysine methyltransferase 2 inhibitors)

Therapeutic Areas

Neoplasms

Active Indication

Neoplasms

Inactive Indication-

Originator Organization

KYORIN Pharmaceutical Co., Ltd.

Active Organization

KYORIN Pharmaceutical Co., Ltd.

Inactive Organization-

Drug Highest PhaseDiscovery

First Approval Date-

Regulation-

Structure

Molecular FormulaC26H30N4O3

InChIKeyOWORSODZTADOQX-IBGZPJMESA-N

CAS Registry2648855-18-7

Author: Harada, Hironori ; Ohishi, Tomokazu ; Shirai, Fumiyuki ; Kawada, Manabu ; Nakamura, Yukio ; Takase, Shohei ; Nakata, Akiko ; Matsuoka, Seiji ; Usui, Masaya ; Yoshida, Minoru ; Sato, Shin ; Umehara, Takashi ; Yamaguchi, Tokio ; Shirouzu, Mikako ; Hashimoto, Noriaki ; Ito, Akihiro ; Maemoto, Yuki ; Sumiya, Tatsunobu ; Nishigaya, Yosuke ; Hiroyama, Takashi ; Shinkai, Yoichi ; Sonoda, Takeshi ; Arata, Mayumi ; Hayashi, Yoshihiro ; Namie, Ryosuke ; Ohba, Shun-Ichi ; Niwa, Hideaki

AbstractSickle cell disease (SCD) is a heritable disorder caused by β-globin gene mutations. Induction of fetal γ-globin is an established therapeutic strategy. Recently, epigenetic modulators, including G9a inhibitors, have been proposed as therapeutic agents. However, the molecular mechanisms whereby these small molecules reactivate γ-globin remain unclear. Here we report the development of a highly selective and non-genotoxic G9a inhibitor, RK-701. RK-701 treatment induces fetal globin expression both in human erythroid cells and in mice. Using RK-701, we find that BGLT3 long non-coding RNA plays an essential role in γ-globin induction. RK-701 selectively upregulates BGLT3 by inhibiting the recruitment of two major γ-globin repressors in complex with G9a onto the BGLT3 gene locus through CHD4, a component of the NuRD complex. Remarkably, BGLT3 is indispensable for γ-globin induction by not only RK-701 but also hydroxyurea and other inducers. The universal role of BGLT3 in γ-globin induction suggests its importance in SCD treatment.

100 Deals associated with RK-701

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