Delving into the Latest Updates on Obesity (Resalis Therapeutics) with Synapse

Overview

Basic Info

Drug Type

ASO

Synonyms-

Target

miR-22

Mechanism

miR-22 inhibitors(microRNA 22 inhibitors)

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication-

Inactive Indication

Obesity

Originator Organization

Resalis Therapeutics SRL

Active Organization-

Inactive Organization

Resalis Therapeutics SRL

Drug Highest PhaseDiscontinuedPreclinical

First Approval Date-

Regulation-

Structure

Boost your research with our RNA technology data.

login

or

view full example data

Boost your research with our RNA technology data.

Obesity and associated pathologies are a dramatically growing problem. New therapies to prevent and/or cure them are strongly needed. Adipose tissue is a logical target for pharmacological intervention, since it is now recognized to exert an important endocrine function, secreting a variety of adipokines affecting, for example, adiposity and insulin resistance. This proof of principle work focuses on the development of novel lipid-mimetic prodrugs reaching fat deposits by the same lymphatic absorption route followed by dietary triglycerides. Pterostilbene, a natural phenolic compound with potential anti-obesity effects, was used as model "cargo", attached via a carbamate group to an ω-aminodecanoate chain linked to either position 1 or position 2 of the glycerol moiety of synthetic triglycerides. The prodrugs underwent position-selective hydrolysis when challenged with pancreatic lipases in vitro. Pterostilbene-containing triglycerides as well as pterostilbene and its metabolites were present in the adipose tissue of mice fed an obesogenic diet containing one or the other of the derivatives. For the first time this approach is used to deliver an obesity antagonist to the adipose tissue. The results demonstrate the feasibility of delivering active compounds to adipose tissue by reversibly incorporating them into triglyceride-mimetic structures. Upon release in the target site these compounds are expected to exert their pharmacological activity precisely where needed.

100 Deals associated with Obesity (Resalis Therapeutics)

Login to view more data