Last update 21 Nov 2024

Disodium Glycyrrhizinate

Last update 21 Nov 2024

Overview

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Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

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Drug Highest PhaseApproved

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Structure

Molecular FormulaC42H62NaO16

InChIKeyKMLYQOUDRJQHIQ-OOFFSTKBSA-N

CAS Registry71277-79-7

100 Clinical Results associated with Disodium Glycyrrhizinate

100 Translational Medicine associated with Disodium Glycyrrhizinate

100 Patents (Medical) associated with Disodium Glycyrrhizinate

Literatures (Medical) associated with Disodium Glycyrrhizinate

09 Jun 2023·Pathogens (Basel, Switzerland)

Curcumin and Its Supramolecular Complex with Disodium Glycyrrhizinate as Potential Drugs for the Liver Fluke Infection Caused by Opisthorchis felineus.

Article

Author: Lou, Yan ; Evseenko, Veronica I ; Li, Meijun ; Sorokina, Irina V ; Lvova, Maria N ; Tsyganov, Michail A ; Minkova, Galina A ; Tolstikova, Tatiana G ; Mordvinov, Viatcheslav A ; Kovner, Anna V ; Avgustinovich, Damira F ; Dushkin, Alexander V ; Ponomarev, Denis V ; Tarasenko, Alena A

Opisthorchiosis is a parasitic liver disease found in mammals that is widespread throughout the world and causes systemic inflammation. Praziquantel remains the drug of choice for the treatment of opisthorchiosis, despite its many adverse effects. An anthelmintic effect is attributed to the main curcuminoid of Curcuma longa L. roots-curcumin (Cur)-along with many other therapeutic properties. To overcome the poor solubility of curcumin in water, a micellar complex of curcumin with the disodium salt of glycyrrhizic acid (Cur:Na₂GA, molar ratio 1:1) was prepared via solid-phase mechanical processing. In vitro experiments revealed a noticeable immobilizing effect of curcumin and of Cur:Na₂GA on mature and juvenile Opisthorchis felineus individuals. In vivo experiments showed that curcumin (50 mg/kg) had an anthelmintic effect after 30 days of administration to O. felineus-infected hamsters, but the effect was weaker than that of a single administration of praziquantel (400 mg/kg). Cur:Na₂GA (50 mg/kg, 30 days), which contains less free curcumin, did not exert this action. The complex, just as free curcumin or better, activated the expression of bile acid synthesis genes (Cyp7A1, Fxr, and Rxra), which was suppressed by O. felineus infection and by praziquantel. Curcumin reduced the rate of inflammatory infiltration, whereas Cur:Na₂GA reduced periductal fibrosis. Immunohistochemically, a decrease in liver inflammation markers was found, which is determined by calculating the numbers of tumor-necrosis-factor-positive cells during the curcumin treatment and of kynurenine-3-monooxygenase-positive cells during the Cur:Na₂GA treatment. A biochemical blood test revealed a normalizing effect of Cur:Na₂GA (comparable to that of curcumin) on lipid metabolism. We believe that the further development and investigation of therapeutics based on curcuminoids in relation Opisthorchis felineus and other trematode infections will be useful for clinical practice and veterinary medicine.

01 Jun 2021·Acta ParasitologicaQ4 · MEDICINE

Effects of Three-time Administration of a Supramolecular Complex of Praziquantel with Disodium Glycyrrhizinate on Trematode Opisthorchis felineus in Hamsters

Q4 · MEDICINE

Article

Author: Goiman, Elena ; Lyakhov, Nikolay ; Tsyganov, Mikhail ; Toporkova, Lyudmila ; Avgustinovich, Damira ; Orlovskaya, Irina ; Dushkin, Aleksander ; Lvova, Maria ; Vishnivetskaya, Galina ; Mordvinov, Viatcheslav

BACKGROUNDPraziquantel (PZQ) is the most commonly used anthelmintic drug for treating trematodiases. It was shown here that PZQ in complex with disodium glycyrrhizinate (PZQ-Na₂GA, in the 1:10 ratio) has higher bioavailability than PZQ alone. Our aim was to determine the effects of three-time administration of PZQ-Na₂GA in an experimental opisthorchiasis felinea model.METHODSThe PZQ-Na₂GA complex (1:10) at a 400 mg/kg dose (meaning 36.4 mg/kg PZQ) was administered to Opisthorchis felineus-infected hamsters three times under a "9:00 am-6:00 pm-9:00 am" regimen (PZQ-Na₂GA × 3). Effects of treatment were assessed as a reduction of helminth load in the hamsters and as changes in physiological, hematological, and blood biochemical parameters. The helminths extracted from the liver of the hamsters that received PZQ-Na₂GA thrice were assayed for sensitivity to PZQ in vitro.RESULTSPZQ-Na₂GA × 3 reduced the number of O. felineus helminths in the liver by 87%, which is 30% better than a previously reported effect of one-time administration of the complex. Meanwhile, relative weights of the liver and thymus diminished, and some hematological parameters improved. The helminths extracted from the hamsters 1 month after the PZQ-Na₂GA × 3 treatment showed elevated sensitivity to PZQ, as determined in vitro.CONCLUSIONCompared with previously published data on the effectiveness of various drugs in experimental opisthorchiasis felinea, PZQ-Na₂GA × 3 exerts the most potent anthelmintic effect. In addition, PZQ-Na₂GA × 3 improves physiological status of O. felineus-infected hamsters and sensitizes the surviving parasites to subsequent PZQ treatment.

01 Mar 2020·Acta Parasitologica

Effectiveness of Repeated Administration of Praziquantel with Disodium Glycyrrhizinate and Two Enantiomers of Praziquantel on Opisthorchis felineus (Rivolta, 1884)

Article

Author: Pakharukova, M Y ; Dushkin, A V ; Mordvinov, V A ; Krasnov, V P ; Avgustinovich, D F ; Tsyganov, M A ; Chulakov, E N

BACKGROUNDNowadays, it is still important to develop effective anti-opisthorchiasis agents. In this work, we tested a complex of praziquantel (PZQ) with a plant origin compound-disodium glycyrrhizinate-in the ratio 1:10 PZQ:Na₂GA, containing 11-fold less of the active ingredient. Our aim was to study various ways to treat trematode Opisthorchis felineus with this complex in vitro. Additionally, an in vitro comparison of the anthelmintic action was made among racemic-PZQ, (R)-PZQ, and (S)-PZQ on juvenile and adult maritae of O. felineus.METHODSWorms extracted from the hamsters were subjected to various regimens of administration of the complex: once a day for 3 days or three times within 1 day. Moreover, mature maritae and juvenile worms of O. felineus were subjected to the comparison the anthelmintic effectiveness of racemic-PZQ, (R)-PZQ, and (S)-PZQ.RESULTSThe O. felineus maritae that received PZQ:Na₂GA (1:10) thrice within 1 day were most strongly affected by the drug. Their motility substantially decreased already on the second day after the last dose, and the percentage of live worms by the end of the experimental period was the lowest. These results indicate a cumulative anthelmintic effect of this substance under the regimen "three times within 1 day." For the first time, we report that among the three substances (racemic-PZQ and two enantiomers), (R)-PZQ has the highest anthelmintic activity, toward both juvenile and sexually mature maritae of O. felineus.CONCLUSIONThese findings suggest that the development of a supramolecular complex of (R)-PZQ with disodium glycyrrhizinate and administration of this complex three times within 1 day are promising approaches.

100 Deals associated with Disodium Glycyrrhizinate

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