Butobarbital

The gastric stability of eight barbiturates (BARs) (barbital, primidone, allobarbital, phenobarbital, cyclobarbital, pentobarbital, secobarbital, and thiobutabarbital (TBB)) was examined in artificial gastric juice using LC/UV detection. Among the eight BARs, only TBB was degraded at higher temperatures. Furthermore, the degradation product of TBB was isolated, structurally analyzed, and finally identified as 5-butan-2-yl-5-ethyl-1,3-diazinane-2,4,6-trione, also known as butabarbital. The study elucidated that butabarbital was formed by substituting the sulfur atom of the carbonyl group at the 2-position of TBB with an oxygen atom under acidic condition.

Mixtures of chiral and achiral building blocks of supramols. exhibit interesting cooperative properties, as indicated by the nonlinear relationship between chiral properties and the mole fraction of chiral building blocks.However, the nonlinear composition dependence of the chiral recognition capability of spherical mixed micelles is poorly understood.This study hypothesized that the phenomenon could be described by the regular solution theory reported to be able to describe critical micelle concentration (CMC) and partition coefficients of the mixed micelle by interaction parameters β and B, resp.The CMC and mole fraction of chiral surfactant in the mixed micelle were simulated by using the theory of varying β and CMC of the two surfactants.Equations that describe the enantioselectivity are newly derived in this work, and the dependency of the enantioselectivity on B was studied in detail.The regular solution theory was applied to the mixed micellar electrokinetic chromatog. (MEKC) for the first time.It was found that the formula can describe the nonlinear composition dependency of the enantioselectivity of the mixed MEKC.The partition coefficient determined by MEKC was in agreement with the β vs. B relation, which was previously reported.