Last update 24 Jul 2025

TMV-018

Overview

Basic Info

Drug Type
Oncolytic virus
Synonyms
TMV 018
Target
CDA
Action
modulators
Mechanism
CDA modulators(Cytidine deaminase modulators)
Therapeutic Areas
NeoplasmsDigestive System Disorders
Active Indication
Gastrointestinal Neoplasms
Inactive Indication
Colorectal CancerEsophageal CarcinomaStomach Cancer
Originator Organization
Themis Bioscience GmbHThemis Bioscience GmbH
Active Organization
Themis Bioscience GmbHThemis Bioscience GmbH
Inactive Organization-
License Organization
Themis Bioscience GmbHThemis Bioscience GmbHMax-Planck-Innovation GmbHMax-Planck-Innovation GmbHMax Planck Institute of BiochemistryMax Planck Institute of Biochemistry
+ [1]
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with TMV-018
NCT04195373
/ WithdrawnPhase 1
A Phase I Open-label, Safety Study of Intra-tumoral Application of TMV-018 in Combination With 5-FC or Anti-PD-1 Therapy in Patients With Tumors of the Gastrointestinal Tract
EUCTR2019-003550-88-DE
/ Not yet recruitingPhase 1/2
Full title of the trial: A Phase I/II open-label, dose-escalation, safety, clinical activity, pharmacokinetic and pharmacodynamic study of intra-tumoral application of TMV-018 in combination with 5-Fluorocytosine or anti-PD-1 therapy in patients with tumors. - TMV-018-101
100 Clinical Results associated with TMV-018
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100 Translational Medicine associated with TMV-018
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100 Patents (Medical) associated with TMV-018
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100 Deals associated with TMV-018
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Gastrointestinal NeoplasmsPhase 2-
Themis Bioscience GmbHThemis Bioscience GmbH
-
Colorectal CancerPhase 1
Germany
Themis Bioscience GmbHThemis Bioscience GmbH
23 Nov 2020
Esophageal CarcinomaPhase 1
Germany
Themis Bioscience GmbHThemis Bioscience GmbH
23 Nov 2020
Stomach CancerPhase 1
Germany
Themis Bioscience GmbHThemis Bioscience GmbH
23 Nov 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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