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Last update 20 Mar 2025

Methylphenobarbital

Last update 20 Mar 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

1-Methylphenobarbital, 5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trione, 5-ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione

+ [10]

Target

GABAA receptor

Action

agonists

Mechanism

GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)

Therapeutic Areas

Nervous System DiseasesOther Diseases

Active Indication

EpilepsySedation

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC13H14N2O3

InChIKeyALARQZQTBTVLJV-UHFFFAOYSA-N

CAS Registry115-38-8

100 Clinical Results associated with Methylphenobarbital

100 Translational Medicine associated with Methylphenobarbital

100 Patents (Medical) associated with Methylphenobarbital

1,090

Literatures (Medical) associated with Methylphenobarbital

01 Jan 2024·Methods in Molecular Biology

Analysis of Barbiturates in Urine by LC-MS/MS

Article

Author: Horne, Hunter ; Janis, Gregory ; Campbell, Matthew ; Ketha, Hemamalini

In the method described here, an aliquot of a urine sample is analyzed to detect barbiturates through dilution and ultra-high-performance chromatography-tandem mass spectrometry (UPLC-MS/MS) using deuterated internal standards. This assay detects the presence of nine barbiturate drugs-amobarbital, barbital, butalbital, butabarbital, mephobarbital, secobarbital, pentobarbital, phenobarbital, and thiopental. This protocol describes two LC separation methods-first LC method (2.2 min/sample) is intended to be used as a first step of the analysis that does not separate amobarbital and pentobarbital, and a second, longer (2.7 min/sample) LC method is intended to be used only for samples which have a peak in the amobarbital/pentobarbital retention time on the shorter LC method. Since the frequency at which amobarbital and pentobarbital are observed in clinical populations is low, the shorter LC method helps gain efficiency in a high-volume laboratory environment. Additional features of this protocol that help in efficiency gain are automated extraction using Hamilton™ liquid handling system and algorithmic data review using Ascent™ software.

01 May 2023·Journal of Pharmaceutical and Biomedical Analysis

New approach for barbiturates, phenytoin, methyprylon and glutethimide determination and fragmentation (UHPLC-MS/MS)

Article

Author: Tusiewicz, Kaja ; Wachełko, Olga ; Zawadzki, Marcin ; Szpot, Paweł

Barbiturates which are old pharmaceutical drugs are still widely used in medical treatment of epilepsy and for general anesthesia. To date, more than 2500 different barbituric acid analogs have been synthesized, and 50 of them were introduced into medical use over the last century. Due to their highly addictive properties, pharmaceuticals containing barbiturates are under strict control in many countries. However, by considering the worldwide problem with new psychoactive substances (NPS) the introduction of new designer barbiturate analogs into the dark market might serve a serious public health problem in the near future. For this reason there is an increasing need for application methods for barbiturates monitoring in biological samples. The UHPLC-QqQ-MS/MS method for determination of 15 barbiturates, phenytoin, methyprylon and glutethimide was developed and fully validated. The biological sample volume was reduced to only 50 µL. A simple LLE (pH 3 with ethyl acetate) was successfully applied. The lower LOQ was 10 ng/mL. The method enables differentiation of structural isomers: hexobarbital and cyclobarbital; as well as amobarbital and pentobarbital. Chromatographic separation was achieved with the use of the alkaline mobile phase (pH 9) and Acquity UPLC BEH C18 column. Furthermore, the novel fragmentation mechanism of barbiturates was proposed, which may have a great impact in identification of novel barbiturates analogs introduced to illegal marketplaces. The presented technique has a great potential to be applied in forensic, clinical and veterinary toxicological laboratories, as was evidenced by the positive results of international proficiency tests.

01 Feb 2023·Chemistry & Biodiversity

GC/MS and LC/MS Phytochemical Analysis of Vigna unguiculata L. Walp Pod

Article

Author: Farooqui, Mazahar ; Pradhan, Vidya ; Mahavirsing Dinore, Jaysing ; Shivaji Patil, Harshal ; Farooqui, Samreen

AbstractVigna unguiculata (L. Walp) or Cowpea pod methanolic extracts phytochemical analysis, total phenolic content (TPC), and secondary metabolite profiling were determined using gas chromatography‐mass spectrometry (GC/MS) and liquid chromatography‐mass spectrometry (LC/MS) analysis. GC/MS analysis revealed twenty compounds in the extract, while LC/MS analysis identified twenty‐four compounds. GC/MS chromatogram analysis suggested the presence of opioid α‐N‐Normethadol a major constituent found in methanolic extract and fatty acid esters carotenoid is found second major constituent. LC/MS chromatogram and the mass spectral analysis demonstrated the presence of flavonoids, carotenoids, and alkaloids as major phytochemicals. We investigated the antibacterial, anti‐fungal, and anti‐oxidant activity of pod methanolic extract. The extract was found equally effective against E. coli, S. pyogenes, and P. aeruginosa with MIC 100 μg/mL similar to the standard Ampicillin (MIC 100 μg/mL). C. albicans were found to be most susceptible to Vign unguiculata pods methanolic extract with a MIC of 250 μg/mL. The pod extract showed significant DPPH scavenging activity (IC50=78.38±0.15) which suggests its antioxidant potential.

100 Deals associated with Methylphenobarbital

External Link

KEGG	Wiki	ATC	Drug Bank
-	Methylphenobarbital	N03AA01	DB00849

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Epilepsy	-	-	-
Sedation	-	-	-

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