Multidimensional supramol. assembly (CB[6]-PA) based on cucurbit[6]uril (CB[6]) was constructed via the outer-surface interactions of CB[6] with a structure-directing agent of pamoic acid (H2PA).Most impressively, crystal CB[6]-PA exhibited satisfactory selectivity for the capture of Cd2+ and Hg2+ cations, and released Cd2+ and Hg2+ cations under acidic condition.This reversible process allows for capturing applications of Cd2+ and Hg2+ cations.Furthermore, crystalline CB[6]-PA-Cd demonstrated enhanced fluorescence properties compared with H2PA ligands.CB[6]-PA-Cd could be employed for the precise detection of methylmalonic acid (EA or MMA) as a biomarker of septicemia.The introduction of EA resulted in the fluorescence quenching of CB[6]-PA-Cd, the mechanism of sensing EA was clearly elucidated.A portable detection platform was designed to augment the efficiency of EA detection.To promote biol. applications, the exceptional probe capable of exactly detecting EA in serum samples had been substantiated.CB[6]-PA-Cd exhibited a negligible cytotoxicity, favorable cytocompatibility, and good hemocompatibility.Thus, these results will bring about new enlightenment for the fabrication of light-emitting materials and high-resolution bio-imaging probes based on cucurbit[n]urils.

01 Feb 2025·Microchemical Journal

A multi-responsive luminescent sensor based on a CB[6] supramolecular assembly for effective sensing and removing MnO4− and cetylpyridinium chloride in aqueous solutions

Author: Liu, Mei ; Wang, Qiqi ; Liu, Ailun ; Shi, Lulu ; Zhou, Tingting

A cucurbit[6]uril (CB[6]) based supramol. assembly CB[6]-PA (1) (PA = pamoic acid) was successfully synthesized under solvothermal conditions.The performance study shows that 1 can be used as a fluorescence sensor for oxoanions (MnO^4-) and cationic surfactants cetylpyridinium chloride (CPC) detection with the limit of detection (LOD) values of 5.34 ppb (0.034μM) and 28.99 ppb (0.085μM), resp.Meanwhile, 1 can remove MnO₄^- through an oxidation-reduction reaction with the removal rate of 99.87%.Interestingly, we successfully prepared 1 based hydrogels and hydrogel beads for clothing anti-counterfeiting and visual inspection of CPC in water, resp.This work proposes a low cost, rapid, and efficient method for detecting environmental pollutants.Addnl., this study also expands the application fields of CB[n]-based fluorescence supramol. assemblies.

01 Feb 2025·Journal of Photochemistry and Photobiology A: Chemistry

Detection of Non-caloric artificial sweetener saccharine in soft drinks and ice-creams through intermolecular H-bonding by using AuNPs-based fluorescent probe

Author: Devaraj, Nataraj ; Thangadurai Thangaian, Daniel ; Ayyavu, Sowndarya

Artificial sweeteners (ASs) are widely utilized as sugar substitutes in food products.However, excessive consumption of ASs poses potential health risks, necessitating their early detection.In this study, pamoic acid (PA)-functionalized gold nanoparticles (PA@AuNPs) were employed for the detection of ASs using fluorescence spectroscopy.The PA@AuNPs exhibited high selectivity and excellent sensitivity towards saccharine (SAC) (LoD (limit of detection) = 0.14 x 10^-6 M and LoQ (limit of quantification) = 0.47 x 10^-6 M), compared to other com. available ASs.The fluorescence emission intensity of PA@AuNPs was significantly quenched (∼3-fold) upon the addition of SAC (0 → 50 x 10^-6 M) through the formation of a ground state complex, PA@AuNPs.SACThis complex formation was corroborated by FTIR anal.The non-radiative process validated by time-resolved fluorescence anal.Morphol. anal. revealed that the spherical morphol. of PA@AuNPs remained unchanged upon SAC interaction.PA@AuNPs effectively detected SAC in soft drinks and ice creams, with recovery ranges from 121% to 105%.

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Indication	Highest Phase	Country/Location	Organization	Date
Visceral Pain	Preclinical	United States	Temple University School of Medicine	01 Oct 2010

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