CBX-16

DOYLESTOWN, Pa., Jan. 19, 2023 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE), a biopharmaceutical company focused on developing novel synthetic lethality-based cancer therapeutics targeting DNA damage response (DDR) pathways, today announced that it will participate in the 6th Annual DDR Inhibitors Summit, held in Boston, Massachusetts from January 24 – January 26, 2023. Oren Gilad, Ph.D., President and Chief Executive Officer of Aprea, will participate in a panel discussion entitled “How Are Newer Targets Being Validated to Move Towards Clinical Trials?” and present in two sessions. In addition, Eric Brown, Ph.D., Scientific Consultant to Aprea and a member of the Scientific Advisory Board, will present on Repli-Biom, Aprea’s proprietary discovery platform of novel synthetic lethal targets and biomarkers. Details for the panel and presentations are as follows: Panel Discussion: How are Newer Targets Being Validated to Move Towards Clinical Trials?Date & Time: Wednesday, January 25, 2023 at 5:30 pm ETSession: Exploring Novel Targets on the Horizon & Discussing Their Potential as Monotherapy AgentsPresenter: Oren Gilad, Ph.D., President and Chief Executive Officer Presentation: Understanding DDRi’s In the Clinic: Why is Toxicity Such a Big Issue?Date & Time: Thursday, January 26, 2023 at 9:00 am ETSession: Unpacking an Ongoing Clinical Challenge & DDR Inhibition’s Biggest Obstacle: Toxicity Presenter: Oren Gilad, Ph.D., President and Chief Executive Officer Presentation: Repli-Biom: a Novel Proteo-Genomic Approach to Identify Predictive Biomarkers of DDR Inhibitor EfficacyDate & Time: Thursday, January 26, 2023 at 11:30 am ETSession: Pondering Patient Selection: Improving Targeting Using Biomarkers & Screening PlatformsPresenter: Eric Brown, Ph.D., Scientific Consultant Presentation: Adding On to Monotherapy: Combining DDR InhibitorsDate & Time: Thursday, January 26, 2023 at 1:30 pm ET Session: Conducting Combination Studies: A Two-Birds-One-Stone Approach to Tackling Toxicity & ResistancePresenter: Oren Gilad, Ph.D., President and Chief Executive Officer About Aprea Therapeutics, Inc. Aprea Therapeutics, Inc. is a biopharmaceutical company headquartered in Doylestown, Pennsylvania, focused on developing and commercializing novel synthetic lethality-based cancer therapeutics targeting a critical pathway and some of the most central targets in DDR and cancer progression. The Company’s lead program is ATRN-119, a clinical-stage small molecule ATR inhibitor being developed for solid tumor indications. Our WEE1inhibitor is being advanced to IND submission. For more information, please visit the company website at www.aprea.com. The Company may use, and intends to use, its investor relations website at https://ir.aprea.com/ as a means of disclosing material nonpublic information and for complying with its disclosure obligations under Regulation FD. Forward Looking Statement Certain information contained in this press release includes “forward-looking statements”, within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, related to our study analyses, clinical trials, regulatory submissions, and projected cash position. We may, in some cases use terms such as “future,” “predicts,” “believes,” “potential,” “continue,” “anticipates,” “estimates,” “expects,” “plans,” “intends,” “targeting,” “confidence,” “may,” “could,” “might,” “likely,” “will,” “should” or other words that convey uncertainty of the future events or outcomes to identify these forward-looking statements. Our forward-looking statements are based on current beliefs and expectations of our management team that involve risks, potential changes in circumstances, assumptions, and uncertainties. Any or all of the forward-looking statements may turn out to be wrong or be affected by inaccurate assumptions we might make or by known or unknown risks and uncertainties. These forward-looking statements are subject to risks and uncertainties including risks related to the success and timing of our clinical trials or other studies, risks associated with the coronavirus pandemic and the other risks set forth in our filings with the U.S. Securities and Exchange Commission. For all these reasons, actual results and developments could be materially different from those expressed in or implied by our forward-looking statements. You are cautioned not to place undue reliance on these forward-looking statements, which are made only as of the date of this press release. We undertake no obligation to publicly update such forward-looking statements to reflect subsequent events or circumstances. Source: Aprea Therapeutics, Inc. Corporate Contacts: Scott M. CoianteSr. Vice President and Chief Financial Officer617-463-9385 Gregory A. KorbelSr. Vice President and Chief Operating Officer617-463-9385 Investors and Mediaaprea@argotpartners.com212-600-1902

VANCOUVER, British Columbia, Sept. 28, 2022 (GLOBE NEWSWIRE) -- Rakovina Therapeutics Inc. (TSX-V: RKV) (“the Company”), a biopharmaceutical company committed to advancing new cancer therapies based on novel DNA-damage response (DDR) technologies, is pleased to announce two upcoming conference presentations. The 34th EORTC-NCI-AACR Molecular Targets and Cancer Therapeutics Symposium being held in Barcelona, Spain, October 26-28, 2022 is a joint meeting of the European Oncology Research and Therapeutics Consortium, the US National Cancer Institute and the American Association for Cancer Research. The meeting focuses on preclinical and phase I human clinical trials, enabling and facilitating in-depth scientific discussions on the latest developments in therapeutic targets and experimental drugs and attracts academics, scientists and pharmaceutical industry representatives from around the globe. The 6th Annual DDR Inhibitors Summit being held in Boston, January 24-26, 2023 will cover both the preclinical and clinical DDR inhibitor landscape and establish how the field is addressing the major hurdle to drug development – toxicity. From reviewing progress with both novel and established targets to utilizing inhibitors in combination studies and improving patient selection with improved biomarkers, this meeting will give a comprehensive and up-to-date overview of the field. “We have previously presented data that suggest promising activity for our novel kt-3000 series drug candidates as a potential treatment for Ewing sarcoma and other treatment-resistant cancers,” said Professor Mads Daugaard, PhD, president & chief scientific officer of Rakovina Therapeutics Inc. “We look forward to sharing additional advancements with the global oncology community and potential pharmaceutical development partners at these upcoming meetings.” Rakovina Therapeutics’ kt-3000 series represents a novel class of bi-functional small-molecule drug candidates that has been designed to combine inhibition of both PARP and HDAC in a single molecule as to potentially overcome treatment resistance in the treatment of Ewing sarcoma and other cancers. Ewing sarcoma is a cancer that occurs primarily in the bone or soft tissues and is the second most common type of bone cancer affecting children and young adults. Approximately thirty percent of patients will experience recurrence within five years following treatment. The prognosis for patients with recurrent or progressive Ewing sarcoma is poor with average survival from the time of relapse of only 14 months. Development of the kt-3000 series is supported, in part, by the St. Baldrick’s Foundation Martha’s BEST Grant for All, which is aimed at developing new treatments for Ewing sarcoma, an aggressive bone and soft tissue cancer in children and young adults. About Rakovina Therapeutics Inc. Rakovina Therapeutics Inc. is focused on the development of new cancer treatments based on novel DNA-damage response (DDR) technologies. The Company has established a pipeline of novel DNA-damage response inhibitors with the goal of advancing one or more drug candidates into human clinical trials and obtaining marketing approval for new cancer therapeutics from Health Canada, the United States Food and Drug Administration and similar international regulatory agencies. Further information may be found at . Additional Information The TSXV has neither approved nor disapproved the content of this press release. Neither the TSXV nor its Regulation Services Provider (as that term is defined in policies of the TSXV) accepts responsibility for the adequacy or accuracy of this release. Notice regarding forward-looking statements: This release includes forward-looking statements regarding the Company and its respective business, which may include, but is not limited to, statements with respect to the proposed business plan of the Company and other statements. Often, but not always, forward-looking statements can be identified by the use of words such as “plans”, “is expected”, “expects”, “scheduled”, “intends”, “contemplates”, “anticipates”, “believes”, “proposes” or variations (including negative variations) of such words and phrases, or state that certain actions, events, or results “may”, “could”, “would”, “might” or “will” be taken, occur or be achieved. Such statements are based on the current expectations of the management of the Company. The forward-looking events and circumstances discussed in this release may not occur by certain specified dates or at all and could differ materially as a result of known and unknown risk factors and uncertainties affecting the Company, including risks regarding the medical device industry, economic factors, regulatory factors, the equity markets generally and risks associated with growth and competition. Although the Company has attempted to identify important factors that could cause actual actions, events, or results to differ materially from those described in forward-looking statements, there may be other factors that cause actions, events, or results to differ from those anticipated, estimated or intended. No forward-looking statement can be guaranteed. Except as required by applicable securities laws, forward-looking statements speak only as of the date on which they are made and the Company undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events, or otherwise. The reader is referred to the Company’s most recent filings on SEDAR for a more complete discussion of all applicable risk factors and their potential effects, copies of which may be accessed through the Company’s pro at . Contact: Rakovina Therapeutics Inc. David Hyman Chief Financial Officer Email: info@rakovinatherapeutics.com Investor Relations Contact IR@rakovinatherapeutics.com Media Contact MEDIA@rakovinatherapeutics.com