BACKGROUNDTo evaluate the effect of a single session of micropulse laser trabeculoplasty on the cornea in eyes with primary open-angle glaucoma and pseudoexfoliation glaucoma.METHODSThis single-centre, prospective, case series enrolled patients with primary open-angle and pseudoexfoliation glaucoma under treatment with glaucoma agents that required additional intraocular pressure reduction. Eyes underwent 360 degrees treatment with 532 nm micropulse laser trabeculoplasty. Central corneal thickness, endothelial cell count, hexagonal cell ratio and co-efficient of variation of endothelial cells were measured before micropulse laser trabeculoplasty and at one, three and six months after treatment.RESULTSTwenty eyes of 20 patients (mean age 67.6 ± 8.0 years) with primary open-angle glaucoma and 18 eyes of 18 patients (mean age 71.44 ± 6.43 years) with pseudoexfoliation glaucoma were included in the study. Treatment with micropulse laser trabeculoplasty resulted in statistically significantly lower intraocular pressure compared to baseline in both primary open-angle and pseudoexfoliation glaucoma eyes (p < 0.0001 at both comparisons). Central corneal thickness, endothelial cell count, hexagonal cell ratio and co-efficient of variation of the endothelial cell size showed no significant change between baseline and six months after micropulse laser trabeculoplasty in both primary open-angle and pseudoexfoliation glaucoma eyes.CONCLUSIONA single session of micropulse laser trabeculoplasty did not affect central corneal thickness and corneal endothelium parameters in eyes with primary open-angle and pseudoexfoliation glaucoma.

01 Dec 2010·Annals of EpidemiologyQ3 · MEDICINE

Glaucoma Medications and Mortality: A Retrospective Cohort Study

Q3 · MEDICINE

Article

Author: Dustin D. French ; Curtis E. Margo

PURPOSEThis study presents a retrospective, cohort analysis to estimate the 4-year rate of all-cause risk-adjusted mortality for veterans who were dispensed glaucoma medications. The main outcome measures was hazard of death according to glaucoma medication exposure.METHODSBeneficiaries 40 years and older enrolled in Veterans Health Administration (VHA) with International Disease Classification diagnoses of glaucoma. VHA clinical and pharmacy data sets were linked with a national VHA mortality registry. Patients were identified with a primary diagnosis of glaucoma were then put into one of two groups, glaucoma medication exposure or nonexposure medication group. Four-year survival analysis using the Cox proportional hazard method was adjusted for comorbidities using pertinent demographic characteristics and hierarchical condition categories from the Centers for Medicare and Medicaid Services.RESULTSOf 214,971 beneficiaries with glaucoma or suspected glaucoma, 25,148 (11.7%) died during the study period. Compared to unexposed patients with glaucoma, the use of any class of glaucoma medication was associated with a statistically significant 7% reduced hazard of death (adjusted hazard ratio, 0.93; 95% confidence interval: 0.90-0.95). Reduced risk of death was found for multiple topical medication use, but not individual glaucoma agents.CONCLUSIONSThe seemingly inexplicable protective effect of glaucoma agents on all-cause mortality may best be explained by unmeasured confounding variables involved in the clinical decision of whether or not to treat patients with limited life expectancy for glaucoma.

01 Jul 2010·IDrugs : the investigational drugs journal

Association for Research in Vision and Ophthalmology (ARVO)--2010 Annual Meeting. For Sight: The Future of Eye and Vision Research--part 2.

Author: Hookes, Livia

The 2010 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), held in Fort Lauderdale, FL, USA, included topics covering new therapeutic developments in the field of eye and vision research. This conference report highlights selected presentations on the development of OT-440 (Othera Pharmaceuticals Inc) for the potential treatment of glaucoma, an extended-release implant of brimonidine (pSivida Corp) for ocular hypertension, AR-12286 (Aerie Pharmaceuticals Inc) for ocular hypertension or glaucoma, AC-8 (Calmune Corp/RiboVax Biotechnologies SA) for ocular diseases following HSV infection, and fidarestat (Sanwa Kagaku Kenkyusho Co Ltd) and the recombinant proteins NOV and NOVCter (INSERM/University Rene Descartes) for corneal neovascularization.

100 Deals associated with Glaucoma Therapeutics(Othera Pharmaceuticals)

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Glaucoma	Preclinical	-	Colby	-

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis


No Data

Glaucoma Therapeutics(Othera Pharmaceuticals)

Overview

Basic Info

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation