Author: Runqing Zhu ; Zhanqiu Yang ; Hongbing Tang ; Zhijiao Tang ; Wei Hou ; Qiaoyang Xian ; Qiong Zhong ; Wei Wang ; Shu-Yuan Xiao ; Yong Wang ; Li Wen ; Jun Zhou

An inactivated vaccine for severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) was evaluated in rhesus monkeys. The monkeys were inoculated intramuscularly (i.m.) with 0.5, 5, 50, or 5000 microg of vaccine, or PBS as control, and boosted on day 7. After 3 weeks, they were challenged with the NS-1 strain of SARS-CoV. The humoral and mucosal immune responses, clinical signs, chemical indices and viremia were monitored following the immunization and challenge. The control animals who received PBS developed atypical SAR-CoV infection after viral challenge, according to clinical, virological and pathological findings. No systematic side effects were observed in vaccinated animals post-immunization, even in at the high dose of 5000 microg. The 50 microg dosage of vaccine elicited SARS-CoV specific immune responses against viral infection as compared to the partial immunity elicited by 0.5 and 5 microg doses. The results show that this inactivated vaccine can induce effective concomitant humoral and mucosal immunity against SARS-CoV infection, is safe in monkeys, and the vaccine maybe a good candidate for clinical trials.

01 Dec 2003·The LancetQ1 · MEDICINE

Effects of a SARS-associated coronavirus vaccine in monkeys

Q1 · MEDICINE

Article

Author: Azaibi Tamin ; Leonardo D'Aiuto ; Wentao Gao ; Edward Nwanegbo ; Simon Barratt-Boyes ; Paul D Robbins ; Adam Soloff ; Andrea Gambotto ; William J Bellini

The causative agent of severe acute respiratory syndrome (SARS) has been identified as a new type of coronavirus. Here, we have investigated the ability of adenoviral delivery of codon-optimised SARS-CoV strain Urbani structural antigens spike protein S1 fragment, membrane protein, and nucleocapsid protein to induce virus-specific broad immunity in rhesus macaques. We immunised rhesus macaques intramuscularly with a combination of the three Ad5-SARS-CoV vectors or a control vector and gave a booster vaccination on day 28. The vaccinated animals all had antibody responses against spike protein S1 fragment and T-cell responses against the nucleocapsid protein. All vaccinated animals showed strong neutralising antibody responses to SARS-CoV infection in vitro. These results show that an adenoviral-based vaccine can induce strong SARS-CoV-specific immune responses in the monkey, and hold promise for development of a protective vaccine against the SARS causal agent.

01 Dec 2003·Expert review of vaccines

AlphaVax receives NIAID contract to support development of HIV vaccine.

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Indication	Highest Phase	Country/Location	Organization	Date
Coronavirus Infections	Preclinical	US	AlphaVax, Inc.	-

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