Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.

Start Date01 Jan 2003

Sponsor / Collaborator

Radboud University Medical Center

100 Clinical Results associated with Tetraethylammonium

100 Translational Medicine associated with Tetraethylammonium

100 Patents (Medical) associated with Tetraethylammonium

6,630

Literatures (Medical) associated with Tetraethylammonium

01 Apr 2025·Journal of Molecular Liquids

Unveiling interfacial molarities: In situ probing of nanoemulsion interfaces stabilized by cationic and anionic surfactants via chemical trapping

Author: Yan, Runxuan ; Xu, Baocai ; Zhao, Li ; Zhu, Xiaoxuan ; Song, Yao ; Liu, Changyao ; Xu, Xiaoting

The properties and applications of nanoemulsions are critically governed by the interfacial composition at the oil-water interface.Conventional techniques, which primarily simulate interfacial behavior, exhibit notable limitations in capturing authentic mol. arrangements.In contrast, the chem. trapping (CT) method enables in situ probing of interfacial composition, offering mol.-level insights into nanoemulsion behavior.Here, sodium lauryl Me taurine (SLMT) and cetyltrimethylammonium bromide (CTAB) nanoemulsions were prepared under different surfactant concentrations, oil fractions, homogenization methods (high-pressure homogenization vs. ultrasonication), and salt addition conditions.The emulsions were characterized by dynamic light scattering (DLS) and stability anal., while their interfacial compositions were investigated using the CT method, providing mol.-level insights into droplet size and stability changes.The results revealed that changes in surfactant concentration and oil fraction directly impacted droplet size and emulsion stability, corresponding to shifts in interfacial molarities.Addnl., nanoemulsions produced via ultrasonication displayed interfacial properties comparable to those produced by high-pressure homogenization, validating ultrasonication as a scalable alternative.Notably, SLMT emulsions displayed ion-specific effects: tetrapropylammonium (TPA⁺) and tetraethylammonium (TEA⁺) ions formed ion pairs with sulfonate headgroups, displacing interfacial water, enhancing mol. packing, and reducing curvature, thereby increasing droplet size.These results establish a direct structure-property relationship between interfacial composition and nanoemulsion performance, providing a rational framework for designing functional nanoemulsions in food, cosmetics, and pharmaceutical applications.

01 Apr 2025·Talanta

Ready-to-use polymeric films used as the electrified liquid-liquid interface supports

Article

Author: Rudnicki, Konrad ; Poltorak, Lukasz ; Powałka, Emilia ; Marciniak, Karolina

In this work, we have tested two commercially available polymeric films: one with natural porosity (polyvinylidene difluoride - PVDF) and the other modified to include micropores (ethylene-vinyl acetate - EVA) created through needle puncturing. Subsequently, these films were successfully employed for the miniaturization of the electrified liquid-liquid interface formed between water and 1,2-dichloroethane solutions. The geometry of the membranes was assessed with confocal microscopy, the aqueous phase wettability was evaluated with a drop-shape analyzer whereas their ability to support the electrified liquid-liquid interfaces was followed with ion transfer voltammetry. Finally, the resulting platforms were applied to the electroanalytical detection of 2-phenylethylamine.

01 Apr 2025·Canadian Journal of Physiology and Pharmacology

Histamine H₃ receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats

Article

Author: Godínez-Ramos, Isabel ; Barral, Jaime ; Arias-Montaño, José-Antonio ; González-Sandoval, Carolina

Striatal medium spiny neurons (MSN) form two subpopulations (MSN-D1 and MSN-D2) according to the expression of dopamine D1 or D2 receptors and their target regions. The activation of postsynaptic histamine H1 and H2 receptors increases MSN-D1 and MSN-D2 excitability. Since MSN also express H3 receptors (H3Rs), in this work we explored the effect of their activation on MSN firing. Electrophysiological recordings (whole-cell patch-clamp, current-clamp mode) were conducted on forebrain slices from infantile rats (12–16 postnatal days). In both MSN-D1 and MSN-D2 perfusion with the H3R agonist immepip (1 µmol/L) increased neuronal firing evoked by current injection, an effect reproduced by R-α-methylhistamine (1 µmol/L) and prevented by the antagonist clobenpropit (10 µmol/L). Blockade of N- or P/Q-type voltage-activated calcium channels by ω-conotoxin-GVIA (1 µmol/L) or ω-agatoxin-TK (400 nmol/L) increased MSN firing but did not preclude the immepip effect. The potassium channel blockers 4-aminopyridine (1 mmol/L) and tetraethylammonium (300 µmol/L) increased neuronal firing and prevented the immepip action. Likewise, the KV7 channel blocker XE-991 (10 µmol/L) and the muscarinic receptor agonist carbachol (10 µmol/L) increased MSN firing frequency and occluded the immepip effect. These data indicate that the activation of postsynaptic H3Rs facilitates MSN-D1 and MSN-D2 firing by inhibiting KV7 potassium channels.

100 Deals associated with Tetraethylammonium

External Link

KEGG	Wiki	ATC	Drug Bank
-	Tetraethylammonium	-	DBSALT000173

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Endotoxemia	Phase 1	-	Radboud University Medical Center	01 Jan 2003

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis