Delving into the Latest Updates on MS39 with Synapse

Overview

Basic Info

Drug Type

Proteolysis-targeting chimeras (PROTAC)

Synonyms-

Target

EGFR

Action

degraders

Mechanism

EGFR degraders(Epidermal growth factor receptor erbB1 degraders), Proteolysis

Therapeutic Areas

NeoplasmsRespiratory Diseases

Active Indication

Non-Small Cell Lung Cancer

Inactive Indication-

Originator Organization

Icahn School of Medicine at Mount Sinai

Active Organization

Icahn School of Medicine at Mount Sinai

Inactive Organization-

License Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

To compare the posterior keratometry (PK) values obtained with three instruments based on optical coherence tomography (Anterion [Heidelberg Engineering], IOLMaster 700 [Carl Zeiss Meditec AG], and MS-39 [CSO]), and one Scheimpflug camera biometer (Pentacam AXL Wave; Oculus Optikgeräte GmbH). The average keratometry (Kave), total corneal power (TCP), anterior-to-posterior ratio (A/P ratio), and posterior corneal astigmatism (PCA) were also compared.

Methods::

Measurements by the four instruments, expressed in diopters (D), were compared using repeated measures analysis of variance, when they were normally distributed, or Friedman's test, when they were not.

Results::

One hundred eyes (100 consecutive patients) scheduled to undergo cataract surgery were prospectively enrolled. Statistically significant differences among the Anterion, IOLMaster 700, MS-39, and Pentacam AXL Wave were detected for PK: Anterion: −6.08 ± 0.23 D, IOLMaster 700: −5.77 ± 0.23 D, MS-39: −6.15 ± 0.26 D, and Pentacam AXL Wave: −6.26 ± 0.26 D ( P < .0001); for Kave: Anterion: 43.19 ± 1.50 D, IOLMaster 700: 43.35 ± 1.49 D, MS-39: 43.36 ± 1.53 D, and Pentacam AXL Wave: 43.22 ± 1.55 D ( P < .0001); for the A/P ratio: Anterion: 1.19 ± 0.02, IOLMaster 700: 1.12 ± 0.02, MS-39: 1.20 ± 0.03, Pentacam AXL Wave: 1.22 ± 0.03 ( P < .0001); and for TCP: Anterion: 42.69 ± 1.51 D, IOLMaster 700: 43.36 ± 1.49 D, MS-39: 42.92 ± 1.52 D, and Pentacam AXL Wave: 42.35 ± 1.55 D ( P < .0001). PCA revealed significant differences for the KP(45) and KP(0) vectors ( P < .0001).

Conclusions::

The four instruments showed different PK values. The largest difference was observed with the IOL-Master 700, which provided the flattest PK and the lowest A/P ratio. The measurements cannot be considered interchangeable, and this should be considered when entering PK values into calculators using this parameter for IOL power.

01 Mar 2025·INDIAN JOURNAL OF OPHTHALMOLOGY

Repeatability and agreement of a new anterior segment optical coherence tomography with standard devices in normal, keratoconus, and post-refractive eyes

Article

Author: Shetty, Rohit ; Modak, Durgalaxmi ; Kaweri, Luci ; Nuijts, Rudy M M A ; Khamar, Pooja ; Shetty, Naren ; Arora, Vishal ; Kundu, Gairik

Purpose::

To assess repeatability and agreement of Eyestar 900 (Haag-Streit, Köniz, Switzerland) with Pentacam AXL Wave system (Oculus, Wetzlar, Germany), Anterion (Heidelberg Engineering GmBH, Heidelberg, Germany), and MS-39 (CSO, Florence, Italy) in measuring anterior segment parameters.

Methods::

Two hundred normal eyes, 50 keratoconus (KC) eyes, and 50 post-refractive surgery eyes underwent three sequential scans on each instrument. The order of scans was randomized. Repeatability was assessed using within-subject standard deviation (Sw) and intraclass correlation coefficient (ICC). Bland–Altman analysis was used to assess the 95% limits of agreement.

Results::

Eyestar 900 had comparable repeatability to Anterion and MS-39 across groups. ICC was overall >0.8. Pentacam AXL Wave had lower Sw (better repeatability) across all groups. In normal eyes, Eyestar 900 can be used interchangeably with MS-39 and Anterion (P > 0.23). Eyestar 900 and Pentacam AXL Wave did not show agreement on any parameter, except anterior chamber depth (ACD) (P = 0.92). Eyestar 900 in KC eyes can be used interchangeably with MS-39, except for posterior keratometry (pK) and thinnest corneal thickness (TCT) (P < 0.001), and with Anterion, except for TCT and ACD (P < 0.001). In post-refractive eyes, Eyestar 900 can be used interchangeably with MS-39, except for pK (P < 0.001), and with Anterion, except for ACD (P < 0.001). Pentacam AXL Wave and Eyestar 900 cannot be used interchangeably in KC and post-refractive eyes.

Conclusions::

Newer devices such as Eyestar 900 can be used interchangeably with Anterion and MS-39 in normal eyes and partly in KC and post-refractive eyes. Pentacam AXL Wave and Eyestar 900 cannot be used interchangeably across the various groups. However, these multifunctional hybrid tools of combined topography, AS-OCT, can be helpful in refractive clinics.

01 Sep 2023·Cornea

Comparison of Corneal Thickness Measurements After Customized Corneal Crosslinking Using High-Resolution Optical Coherence Tomography and Scheimpflug Tomography

Article

Author: Wendelstein, Jascha ; Seiler, Theo G. ; Mendes Baiao, Tiago

Purpose::

The aim of this study was to compare the evolution of corneal pachymetry after customized corneal crosslinking (CXL) between Scheimpflug-based and optical coherence–based corneal tomography (OCT).

Methods::

In this retrospective study, central corneal thickness (CCT), thinnest corneal thickness, and epithelial thickness of 33 eyes of 33 patients with keratoconus were measured preoperatively and 1, 3, and 12 months after customized CXL using the Pentacam HR and the MS-39. The mean pachymetry values of measurements were compared with a paired sample t test. Bland–Altman plots and 95% limits of agreement (LoA) were used to assess the agreement between the measurements of the 2 devices.

Results::

The mean age of the participants was 29.7 ± 11.4 years. At baseline, the mean CCT measurements were equal with Pentacam HR (478.30 ± 36.77 μm) and MS-39 (478.46 ± 38.01 μm). After CXL, CCT obtained by Pentacam HR was 460.65 ± 38.69 μm, 464.65 ± 44.45 μm, and 476.77 ± 39.85 μm, and by MS-39 was 478.18 ± 39.50 μm, 472.89 ± 40.92 μm, and 479.51 ± 39.20 μm at 1, 3, and 12 months, respectively. Pentacam HR measured significantly lower CCT (P < 0.05) at months 1 and 3 after CXL. The agreement was smallest between both devices at month 1 (95% LoA −59 to 24 μm) followed by month 3 (95% LoA: −41 to 23 μm). Epithelial thickness, measured with OCT alone, increased significantly at 1 month and regained preoperative levels at 3 months and thereafter.

Conclusions::

After CXL, corneal pachymetry significantly differs between OCT-based and Scheimpflug-based corneal tomography. Pentacam HR seems to underestimate pachymetry when haze is present.

100 Deals associated with MS39

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