Last update 21 Nov 2024

Timonacic

Last update 21 Nov 2024

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

ATC, Timonacic (INN)

+ [4]

Target-

Mechanism-

Therapeutic Areas

Digestive System Disorders

Active Indication

Hepatitis, Chronic

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure

Molecular FormulaC4H7NO2S

InChIKeyDZLNHFMRPBPULJ-UHFFFAOYSA-N

CAS Registry444-27-9

100 Clinical Results associated with Timonacic

100 Translational Medicine associated with Timonacic

100 Patents (Medical) associated with Timonacic

Literatures (Medical) associated with Timonacic

01 May 1998·Journal of Pharmaceutical and Biomedical AnalysisQ3 · MEDICINE

Spectrophotometric investigation of the formed chelate between timonacic and palladium(II) and its analytical applications

Q3 · MEDICINE

Article

Author: A.F.M. El Walily ; O.A. Razak ; S.F. Belal ; R.S. Bakry

A simple spectrophotometric method for the determination of timonacic is presented. The procedure is based on the chelate formation with palladium(II) chloride in buffered medium. The optimum conditions for the complex formation were ascertained and the method was developed for the determination of timonacic in the concentration range of 28-48 micrograms ml-1. The emperical formula of the formed complex was determined, by applying different spectrophotometric methods, at optimum pH of 4.8 and an ionic strength of mu = 0.5. The stoichiometric ratio was found to be 2:1 (timonacic/palladium) as calculated by the mole ratio, continuous variations and Asmus methods. The continuous variations and Nash methods were applied for the determination of the conditional stability constant of the formed yellow-water soluble complex and was found to be 3.27 x 10(7). The proposed methods was found to be suitable for the determination of timonacic in bulk and in its pharmaceutical tablets.

01 Sep 1992·AlcoholQ4 · MEDICINE

The effect of heparegen on antioxidant enzyme activities in ethanol-induced liver injury in rats

Q4 · MEDICINE

Article

Author: A. Holownia ; R. Farbiszewski ; A. Radecka ; M. Chwiecko

SOD, CAT, GSH-Px, and sulfhydryl compounds MDA contents in liver of rats treated with heparegen for 7, 14, and 21 days after alcoholic liver injury have been investigated. After use of this drug, we found beneficial effects on GSH-Px activity, sulfhydryl compounds (total and nonprotein), and MDA content and a partially beneficial effect on SOD and CAT activities. These enzyme activities after 21 days of drug administration were restored. Furthermore, heparegen shortens the time necessary for the return of AIAT and GGTP to normal value. This enzymatic data are supported by histological studies in light microscopy.

01 Jan 1991·Drug and Alcohol DependenceQ2 · MEDICINE

The effect of Heparegen and D-penicillamine on the activity of some ammonia metabolizing enzymes in liver and brain of rats intoxicated with ethanol

Q2 · MEDICINE

Article

Author: Chwiecko, M. ; Farbiszewski, R. ; Holownia, A. ; Pawlowska, D.

This paper reports data on the effect of two drugs: Heparegen (thiazalidine-4-carboxylic acid) and D-penicillamine on the blood ammonia concentration and on some ammonia metabolizing enzymes in liver and brain of rats intoxicated with ethanol. It seems, that both drugs decrease ammonia concentration and simultaneously elevate liver and brain glutamine synthetase activity. The effect of D-penicillamine on the nitrogen metabolism in the damaged liver appears to be more favorable than that of Heparegen.

100 Deals associated with Timonacic

External Link

KEGG	Wiki	ATC	Drug Bank
D08601	-	A05A	DB12856

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Hepatitis, Chronic	-	-	-

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis