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Last update 20 Mar 2025

Timonacic

Last update 20 Mar 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

ATC, Timonacic (INN)

+ [4]

Target-

Action-

Mechanism-

Therapeutic Areas

Digestive System Disorders

Active Indication

HepatitisHepatitis, Chronic

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC4H7NO2S

InChIKeyDZLNHFMRPBPULJ-UHFFFAOYSA-N

CAS Registry444-27-9

100 Clinical Results associated with Timonacic

100 Translational Medicine associated with Timonacic

100 Patents (Medical) associated with Timonacic

760

Literatures (Medical) associated with Timonacic

01 Feb 2025·International Journal of Environmental Research

Petroleum-Contaminated Soil Isolates: A Comparative Study of Naphthalene Biodegradation Kinetics and Metabolic Pathways

Author: Sumathi, K. ; Manian, Rameshpathy

In contrast to phys. and chem. methods, removal of PAHs like naphthalene through the action of microorganisms offers a safe, affordable, and environmentally beneficial method of remediation.The most popular eradication technique is bioremediation as it is a long-term strategy that completely mineralizes naphthalene.Thus, three strains of Citrobacter freundii (VITRPS1), Alcaligenes ammonioxydans (VITRPS2), and Enterobacter cloacae (VITRPS3) isolated from petroleum-contaminated soil carried out the biodegradation of naphthalene in this investigation.The strain VITRPS2 exhibited highest degradation efficiency up to 70.8% for naphthalene and strain VITRPS3 exhibited the lowest with only 14.05%.The degradation rate constant, following first-order kinetics, was determined to be 0.1028 day-1, resulting in a half-life of 6.14 days across different naphthalene concentrationsTo study the inhibition kinetics of naphthalene, the non-linear Andrew-Haldane model was employed, revealing Vmax, Ki, and K values of 1712/day, 0.005597 mg/mL, and 11,380 mg/mL, resp., for the strain A. ammonioxydans (VITRPS2).Using Gas chromatog.mass spectrometry (GCMS), this study seeks to determine the specific metabolic pathway of Naphthalene degradation by identifying and analyzing the intermediate metabolites formed during the process, which included salicylic acid, catechol, and several derivatives of phthalic acid.This strain has promising potential and could be useful in the bioremediation of naphthalene-contaminated locations.

01 Oct 2024·Journal of Ethnopharmacology

A comprehensive study on the regulation of Compound Zaoren Granules on cAMP/CREB signaling pathway and metabolic disorder in CUMS-PCPA induced insomnia rats

Article

Author: Chen, Min ; Wang, Zekun ; Shu, Yachun ; Chen, Chen ; Chen, Yajun ; Li, Danting ; Zhang, Lingfeng ; Yu, Xiaocong

ETHNOPHARMACOLOGICAL RELEVANCECompound Zaoren Granules (CZG), an optimized herbal formulation based on the traditional Chinese medicine prescription Suanzaoren decoction, are designed specifically for insomnia treatment. However, the mechanisms underlying its efficacy in treating insomnia are not yet fully understood.AIM OF THE STUDYThe research investigated the mechanisms of CZG's improvement in insomnia by regulating cAMP/CREB signaling pathway and metabolic profiles.METHODSThe main components of CZG were characterized by liquid chromatography-mass spectrometry (LC-MS). Subsequently, these validated components were applied to network pharmacological analysis to predict signaling pathways associated with insomnia. We evaluated the effect of CZG on BV-2 cells in vitro. We also evaluated the behavioral indexes of CUMS combined with PCPA induced insomnia in rats. HE staining and Nissl staining were used to observe the pathological damage of hippocampus. ELISA was used to detect the levels of various neurotransmitters, orexins, HPA axis, and inflammatory factors in insomnia rats. Then we detected the expression of cAMP/CREB signaling pathway through ELISA, WB, and IHC. Finally, the metabolomics was further analyzed by using UHPLC-QTOF-MS/MS to investigate the changes in the hippocampus of insomnia rats and the possible metabolic pathways were also speculated.RESULTSThe results of CZG in vitro experiments showed that CZG has protective and anti-inflammatory effects on LPS induced BV-2 cells. A total of 161 chemical components were identified in CZG. After conducting network pharmacology analysis through these confirmed components, we select the cAMP/CREB signaling pathway for further investigate. The behavioral research results on insomnia rats showed that CZG significantly prolonged sleep time, mitigated brain tissue pathological damage, and exhibited liver protective properties. CZG treats insomnia by regulating the content of various neurotransmitters, reducing levels of orexin, HPA axis, and inflammatory factors. It can also treat insomnia by upregulating the expression of the cAMP/CREB signaling pathway. Hippocampus metabolomics analysis identified 69 differential metabolites associated with insomnia. The metabolic pathways related to these differential metabolites have also been predicted.CONCLUSIONThese results indicate that CZG can significantly prolong sleep time. CZG is used to treat insomnia by regulating various neurotransmitters, HPA axis, inflammatory factors, cAMP/CREB signaling pathways, and metabolic disorders.

17 Sep 2024·Environmental Science & Technology

Urinary Thioproline and Thioprolinyl Glycine as Specific Biomarkers of Formaldehyde Exposure in Humans

Article

Author: Chan, Wan ; Ham, Yat-Hing ; Pan, Guanrui ; Cai, Zongwei ; Yu, Jian Zhen ; Au, Chun-Kit

Assessment of personal formaldehyde (FA) exposure is most commonly carried out using formate as a biomarker, as it is the major product from FA metabolism. However, formate could also have originated from the metabolism of other endogenous and exogenous substances or from dietary intake, which may give rise to overestimated results with regard to FA exposure. We have developed and validated a liquid chromatography-tandem mass spectrometry (LC-MS/MS) coupled with an isotope-dilution method for rigorous quantitation of two major urinary FA conjugation products: thioproline (SPro) and thioprolinyl glycine (SPro-Gly), formed in the reaction between FA and endogenous cysteine or cysteinyl glycine, respectively, as marker molecules to assess personal FA exposure. Using this newly developed method, we measured the FA exposure levels in cigarette smokers, occupants of a chemistry research laboratory and typical domestic household, and visitors to a Chinese temple with a Pearson correlation coefficient greater than 0.94, showing a strong linear correlation between urinary adduct levels and the airborne FA level. It is believed that quantitation of urinary SPro and SPro-Gly may represent a noninvasive, interference-free method for assessing personal FA exposure.

100 Deals associated with Timonacic

External Link

KEGG	Wiki	ATC	Drug Bank
D08601	-	A05A	DB12856

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Hepatitis	-	-	-
Hepatitis, Chronic	-	-	-

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