Article
Author: Amin, Shivani ; McCormick, Lauren ; Cordon, Jamilet ; Suthar, Mehul S ; Lai, Yen-Ting ; Roederer, Mario ; Minai, Mahnaz ; Nagata, Bianca M ; Wagner, Danielle A ; Doria-Rose, Nicole A ; Trost, Jessica ; Dulan, Caitlyn N M ; Moore, Christopher ; Kwong, Peter D ; Harris, Darcy R ; Bock, Kevin W ; Godbole, Sucheta ; Narvaez, Brandon ; Maldonado, Nahara Vargas ; Chuang, Gwo-Yu ; Werner, Anne P ; Valentin, Daniel ; Nurmukhambetova, Saule T ; Willis, Jacquelyn ; Patel, Mit ; Lorang, Cynthia G ; Carroll, Robin ; Seder, Robert A ; Wang, Lingshu ; Teng, I-Ting ; Sullivan, Nancy J ; Naisan, Mursal ; Laboune, Farida ; Foulds, Kathryn E ; Moliva, Juan I ; Douek, Daniel C ; Olia, Adam S ; Leung, Kwanyee ; Edwards, Darin K ; Basappa, Manjula ; Corbett, Kizzmekia S ; Nason, Martha C ; Wu, Kai ; Todd, John-Paul M ; Henry, Amy R ; Steingrebe, Katelyn ; Ellis, Madison ; Liu, Cuiping ; Van Ry, Alex ; Renzi, Isabella ; Roberts-Torres, Jesmine ; Carfi, Andrea ; Zhang, Yi ; Pessaint, Laurent ; Honeycutt, Christopher Cole ; Mascola, John R ; Andersen, Hanne ; Stewart-Jones, Guillaume ; Shi, Wei ; McCarthy, Elizabeth ; Schmidt, Stephen D ; O'Dell, Sijy ; Malinowski, Agata ; Andrew, Shayne F ; Yang, Eun Sung ; Edara, Venkata-Viswanadh ; Foster, Stephanie L ; Lewis, Mark G ; McDermott, Adrian B ; Lin, Bob C ; Gagne, Matthew ; Flebbe, Dillon R ; Jean-Baptiste, Nazaire ; Flynn, Barbara J ; Dodson, Alan ; Cook, Anthony ; Moore, Ian N
SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to neutralization following immunization with ancestral spike-matched vaccines. It is unclear whether boosting with Omicron-matched vaccines would enhance protection. Here, nonhuman primates that received mRNA-1273 at weeks 0 and 4 were boosted at week 41 with mRNA-1273 or mRNA-Omicron. Neutralizing titers against D614G were 4,760 and 270 reciprocal ID50 at week 6 (peak) and week 41 (preboost), respectively, and 320 and 110 for Omicron. 2 weeks after the boost, titers against D614G and Omicron increased to 5,360 and 2,980 for mRNA-1273 boost and 2,670 and 1,930 for mRNA-Omicron, respectively. Similar increases against BA.2 were observed. Following either boost, 70%-80% of spike-specific B cells were cross-reactive against WA1 and Omicron. Equivalent control of virus replication in lower airways was observed following Omicron challenge 1 month after either boost. These data show that mRNA-1273 and mRNA-Omicron elicit comparable immunity and protection shortly after the boost.