Determination of Tripamide in human urine by high‐performance liquid chromatography and high‐performance liquid chromatography/electrospray ionization tandem mass spectrometry

Q3 · CHEMISTRY

Article

Author: Yunje Kim ; Joungboon Hwang ; Won Lee ; Myungsoo Kim

Abstract:

Tripamide is a drug widely used in clinical practice for the treatment of hypertension and edema. This work evaluated a screening method for Tripamide and its urinary metabolites in human urine, using high‐performance liquid chromatography diode‐array detection (HPLC/DAD). Identification of these metabolites was investigated by high‐performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC/ESI‐MS/MS) after dosing with 15 mg Tripamide. Acid hydrolysis showed that Tripamide is conjugated in the body. Two suspected metabolites were detected by HPLC/DAD. HPLC/ESI‐MS/MS analysis suggested that these metabolites were probably hydroxylated together with loss of the ‐NH2 group and dehydrogenation. These results will be useful in confirmation methods for Tripamide in doping control. Copyright © 2003 John Wiley & Sons, Ltd.

01 May 1988·Journal of clinical pharmacologyQ3 · MEDICINE

The Influence of Hydrochlorothiazide and Tripamide on Serum and Urinary Amylase

Q3 · MEDICINE

Article

Author: Kenneth A. Conrad ; Timothy C. Fagan ; Jarid A. Simons

Pancreatitis and asymptomatic elevations of serum amylase have been reported after therapy with thiazide diuretics. In the current study, the effects of hydrochlorothiazide and tripamide treatment on serum and urinary amylase excretion were investigated in 12 hypertensive volunteers. Two patients developed modest elevations of the serum amylase above the normal range after 12 weeks of treatment with hydrochlorothiazide 50 mg daily, but the mean serum amylase did not change. Hydrochlorothiazide did not produce a statistically significant increase in urinary amylase excretion but did reduce the ratio of salivary amylase/creatinine clearance in a two‐hour urine collection. Tripamide 10 mg daily had no effect on serum or urinary amylase.

01 Jan 1988·Family practice research journal

Multicenter private practice comparison of tripamide and hydrochlorothiazide in the treatment of hypertension.

Article

Author: Bope, E T ; Platt, C W ; Brewer, S C ; Romaker, R R ; Scarbrough, S D ; Polsley, J S ; Cairns, C B ; Fosnaugh, N R ; Leidheiser, P C ; Adams, R C

One hundred fifty-nine patients with essential hypertension were randomly assigned to take 10 mg of tripamide or 50 mg of hydrochlorothiazide once a day for 12 weeks. Both drugs were equally effective in lowering both systolic and diastolic blood pressure in the supine (6/5 vs. 5/5 mm Hg) and standing (8/5 vs 7/6 mm Hg) positions. Tripamide had less effect on serum potassium (0.2 vs. 0.6 mEq/L decrease) and serum uric acid (0.7 vs. 1.2 mg/dL increase) than hydrochlorothiazide. The addition of propranolol to either drug produced a further reduction in blood pressure. The overall incidence and spectrum of adverse reactions were the same for both drugs.

100 Deals associated with Tripamide

External Link

KEGG	Wiki	ATC	Drug Bank
D01895	Tripamide	C02	DB15959

R&D Status

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Indication	Country/Location	Organization	Date
Essential Hypertension	JP	Eisai Co., Ltd.	19 Sep 1981

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