Delving into the Latest Updates on Amlodipine Besylate/Atorvastatin Calcium Hydrate/Perindopril Arginine with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Amlodipine/atorvastatin/perindopril, Lipertance, Statriam

+ [3]

Target

ACE x HMGCR x VDCCs

Action

inhibitors, blockers

Mechanism

ACE inhibitors(Angiotensin-converting enzyme inhibitors), HMG-CoA reductase inhibitors(HMG-CoA reductase inhibitors), VDCCs blockers(Voltage-gated calcium channel blockers)

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization

Les Laboratoires Servier SAS

Active Organization-

Inactive Organization

Les Laboratoires Servier SAS

Drug Highest PhasePendingNDA/BLA

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC25H46N6O7

InChIKeyRYCSJJXKEWBUTI-YDYAIEMNSA-N

CAS Registry612548-45-5

View All Structures (3)

This is a multi-centre, observational, ambispective study, which will retrospectively and prospectively collect clinical and socio-demographic data from medical records of patients with HTN and dyslipidemia initiated with SPC of amlodipine/atorvastatin/perindopril in real clinical settings.
A total of 80 general practitioners and outpatient cardiologists will participate in this non-interventional study 400 patients should be included in the study.

Start Date30 Apr 2023

Sponsor / Collaborator

Servier Russia

NCT04306627

/ Unknown statusPhase 4IIT

Evaluation of Carotid Intima Media Thickness by Treatment of Vascular and Metabolic Factors With Combined Antihypertensive and Hypolipidemic Therapy

The investigators hypothesize that additive effects of combined antihypertensive medications and statin in a single pill combination may better reduce progression of vascular remodeling and inhibit atherosclerosis progression. The fixed association of atorvastatin, perindopril and amlodipine under the name of Lipertance is the first fixed combination of these three groups to control the risk factors that are hypertension and dyslipidemia which can be used both in primary and secondary cardiovascular prevention .

Start Date15 Apr 2020

Sponsor / Collaborator

Yerevan State Medical University

[+1]

NCT03047538

/ WithdrawnPhase 4IIT

Fixed Combination for Lipid and Blood Pressure Control. Randomized Cross-over Study

The aim of this study is to compare the effect of fixed and free combination of atorvastatin/perindopril/amlodipine on blood pressure and lipid levels.

Start Date01 Sep 2017

Sponsor / Collaborator

University of Charles

[+4]

100 Clinical Results associated with Amlodipine Besylate/Atorvastatin Calcium Hydrate/Perindopril Arginine

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100 Translational Medicine associated with Amlodipine Besylate/Atorvastatin Calcium Hydrate/Perindopril Arginine

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100 Patents (Medical) associated with Amlodipine Besylate/Atorvastatin Calcium Hydrate/Perindopril Arginine

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1

Literatures (Medical) associated with Amlodipine Besylate/Atorvastatin Calcium Hydrate/Perindopril Arginine

01 Sep 2017·Revue medicale de Liege

[Lipertance® The ASCOT single-pill combination has finally arrived].

Review

Author: Radermecker, R P

The fixed association of atorvastatin, perindopril and amlodipine was recently launched by the firm SERVIER under the name of Lipertance®. It is the first fixed association of a statin, an ACE inhibitor and a calcium blocker present on the Belgian market to handle the risk factors that are hypertension and dyslipidemia which can be used both in primary and secondary cardiovascular prevention. The interests of such a triple combined therapy are many in terms of morbimortality reduction, as observed in ASCOT trial. Besides these results, the association of these three agents gives probably a synergic effect, which would be more effective to protect both heart and vessels. Moreover, a fixed association will improve treatment compliance and adherence, which are generally quite poor in the management of cardiovascular risk factors. Lipertance® is available with three different doses : 20/5/5 mg, 20/10/5 mg and 40/10/10 mg, respectively for atorvastatin, perindopril and amlodipine. Contraindications and side effects are the same as each component of this association and are well known.

100 Deals associated with Amlodipine Besylate/Atorvastatin Calcium Hydrate/Perindopril Arginine

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