Delving into the Latest Updates on Changtong Oral Liquid with Synapse

Overview

Basic Info

Drug Type

Herbal medicine

Synonyms-

Target-

Mechanism-

Therapeutic Areas

Other Diseases

Active Indication

Surgical Adhesion

Inactive Indication

Acute suppurative appendicitisCholecystitis, AcuteChronic cholecystitis+ [3]

Originator Organization-

Active Organization

The First Military Medical University of the Chinese People's Liberation ArmyGuangzhou Sanyi Biological Medicine Technology Co., Ltd.

Inactive Organization-

Drug Highest PhasePhase 3

First Approval Date-

Regulation-

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1.评价常通口服液用于单纯性阑尾炎、急性化脓性阑尾炎、慢性阑尾炎或因子宫肌瘤而行腹式全子宫切除术、腹式子宫次全切术的腹部手术患者术后腹膜粘连的临床防治效果。 2.评价常通口服液用于腹部手术患者术后腹膜粘连的安全性与不良反应。

[Translation]

1. To evaluate the clinical efficacy of Changtong oral liquid in the prevention and treatment of postoperative peritoneal adhesion in patients with simple appendicitis, acute suppurative appendicitis, chronic appendicitis, or abdominal hysterectomy or subtotal abdominal hysterectomy due to uterine fibroids. 2. To evaluate the safety and adverse reactions of Changtong oral liquid in the treatment of postoperative peritoneal adhesion in patients with abdominal surgery.

Start Date07 Oct 2010

Sponsor / Collaborator

The First Military Medical University of the Chinese People's Liberation Army

[+1]

100 Clinical Results associated with Changtong Oral Liquid

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100 Translational Medicine associated with Changtong Oral Liquid

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100 Patents (Medical) associated with Changtong Oral Liquid

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4

Literatures (Medical) associated with Changtong Oral Liquid

01 Aug 2009·Nan fang yi ke da xue xue bao = Journal of Southern Medical University

[Effect of Changtong oral liquid on fibroblast proliferation in normal and adhesive rat peritoneal tissues].

Article

Author: Zeng, Xu-xin ; Huang, Le-song ; Wang, Chun-xia ; Hou, Lian-bing

OBJECTIVETo investigate the effect of Changtong oral liquid (CTOL) on the proliferation of cultured fibroblasts derived from normal peritoneum (NFs) and adhesive peritoneum (AFs) of rats.METHODSTwenty male SD rats were randomized into 4 groups, including a normal serum group and 3 CTOL groups with CTOL treatment at low, medium or high doses. Serum samples were obtained from the abdominal arteries of the rats after oral treatment with CTOL for 7 days. The fibroblasts were isolated from the peritoneum by means of tissue culture, and the passage 3-8 cells were cultured with the sera of the normal control and CTOL groups for 24, 48, 72 and 96 h. MTT assay was used to observe the proliferation of the fibroblasts.RESULTSThe dose of CTOL was inversely correlated to the absorbance but positively to the growth inhibition rates. Compared with the NFs cultured in normal control rat serum, the NFs in serum from CTOL groups showed no obviously changes in the absorbance at 24 and 48 h, but displayed significant reduction at 72 and 96 h (P<0.01). Compared with the AFs in normal rat serum, the AFs in the 3 CTOL groups all showed significantly decreased absorbance at 24, 48, 72 and 96 h (P<0.05). At the same time point, the inhibition rate of AFs in low-dose CTOL group showed no significant difference from that in the normal control group, but CTOL at a medium dose resulted in a significantly higher inhibition rate of AFs at 72 h (P<0.05). High-dose CTOL produced significant differences in the inhibition rates of AFs and NFs (P<0.05).CONCLUSIONCTOL can inhibit the proliferation of AFs and NFs in vitro. AFs appear to be more sensitive to CTOL, which has a dose-dependent inhibitory effect of AF proliferation.

01 Jun 2005·Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA

Effect of Changtong oral liquid on serum cytokine concentrations in rats with postoperative intestinal adhesion.

Article

Author: Hou, Lian-bing ; Liu, Shi-ting ; Wang, Chun-xia

OBJECTIVETo observe the effects of Changtong oral liquid (CTOL) on the serum levels of tumor necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta(1), interleukin (IL)-1beta, IL-4, IL-6 and IL-10 in rats with postoperative intestinal adhesions.METHODSFifty-four male Sprague-Dawley rats were randomized into 6 equal groups, namely the normal control, model, Simo decoction (SMD) groups and three CTOL groups of low, moderate, and high doses, respectively. Intestinal adhesion was induced in the rats of the groups other than the normal control group. The rats in the normal control and model groups received intragastric administration of distilled water (10 ml/kg), and those in the 4 treatment groups had SMD (10 ml/kg) and CTOL (at 4.3, 8.6 and 17.2 g/kg for low, moderate, and high dose groups, respectively). On day 7 after surgery, blood samples were obtained from the rats for measurement of serum cytokine levels with enzyme-linked immunosorbent assay followed by adhesion grading according to a 5-grade scale.RESULTSCTOL evidently reduced the severity of postoperative adhesions and decreased the serum levels of the proinflammatory cytokines such as TNF-alpha, IL-1beta, TGF-beta(1) and IL-6. However, it had no significant impact on serum levels of the anti-inflammatory cytokines IL-4 and IL-10 in rats with postoperative adhesion.CONCLUSIONSignificant indices for postoperative adhesion assessment are established, which provides the experimental basis for evaluating clinical therapeutic effects of postoperative adhesions as well as for developing new therapeutic drugs.

01 Feb 2005·Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA

[Changtong oral liquid for prevention of postoperative intestinal adhesion: an experimental study].

Article

Author: Hou, Lian-Bing ; Wang, Chun-Xia ; Ma, Yun

OBJECTIVETo observe the effect Changtong oral liquid (CTOL), a traditional Chinese drug preparation, on the prevention of postoperative intestinal adhesion.METHODSFifty-four male SD rats were randomly divided into 6 equal groups, namely the normal control, model control, Simo decoction (SMD, another traditional Chinese drug preparation), and CTOL groups, and CTOL group included three subgroups treated at low, moderate and high doses. Except for those in the normal control group, all the other rats were subjected to operation with Ellis' method for establishing intestinal adhesion models. After the operation, the rats in the normal control and model groups received intragastric administration of distilled water (10 ml/kg), SMD group received SMD administration in similar manner at the dose of 10 ml/kg, and the three CTOL groups had CTOL at the doses of 4.3, 8.6 and 17.2 g/kg, respectively. On day 7 after surgery, blood sample were taken from all the rats to determine the white blood cell (WBC) count and fibrinogen (FIB) concentrations, and the intestinal adhesion was graded.RESULTS AND CONCLUSIONCTOL evidently reduced the severity of postoperative adhesion and decreased WBC count and plasma FIB level, suggesting the efficacy of CTOL in inhibiting the formation of postoperative intestinal adhesion.

100 Deals associated with Changtong Oral Liquid

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Surgical Adhesion	Phase 3	CN	The First Military Medical University of the Chinese People's Liberation Army	14 Aug 2022
Surgical Adhesion	Phase 3	CN	Guangzhou Sanyi Biological Medicine Technology Co., Ltd.	14 Aug 2022
Chronic cholecystitis	Phase 1	CN	The First Military Medical University of the Chinese People's Liberation Army	07 Oct 2010
Uterine Fibroids	Phase 1	CN	The First Military Medical University of the Chinese People's Liberation Army	07 Oct 2010
Uterine Fibroids	Phase 1	CN	Guangzhou Sanyi Biological Medicine Technology Co., Ltd.	07 Oct 2010
Acute suppurative appendicitis	Preclinical	CN	Guangzhou Sanyi Biological Medicine Technology Co., Ltd.	07 Oct 2010
Acute suppurative appendicitis	Preclinical	CN	The First Military Medical University of the Chinese People's Liberation Army	07 Oct 2010
Suppurative appendicitis	Preclinical	CN	Guangzhou Sanyi Biological Medicine Technology Co., Ltd.	07 Oct 2010
Chronic cholecystitis	Discovery	CN	Guangzhou Sanyi Biological Medicine Technology Co., Ltd.	07 Oct 2010
Suppurative appendicitis	Discovery	CN	The First Military Medical University of the Chinese People's Liberation Army	07 Oct 2010