Last update 21 Nov 2024
LP-118
Last update 21 Nov 2024
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms |
Target |
Mechanism Bcl-2 inhibitors(Apoptosis regulator Bcl-2 inhibitors), Bcl-xl inhibitors(Apoptosis regulator Bcl-X inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 1 |
First Approval Date- |
Regulation- |
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Related
4
Clinical Trials associated with LP-118A Phase I/II Study to Investigate the Combination of LP-118, Ponatinib, Vincristine and Dexamethasone in Relapsed/Refractory T-ALL/LBL
A Phase I Study on Safety, Tolerance, Pharmacokinetics and Preliminary Efficacy of LP-118 in Patients with Advanced Malignancies
评估口服BCL-2/BCL-XL抑制剂LP-118在中国晚期恶性肿瘤患者的安全性、耐受性、药代动力学特征以及初步疗效的I期临床研究
[Translation] A Phase I clinical study to evaluate the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of LP-118, an oral BCL-2/BCL-XL inhibitor, in Chinese patients with advanced malignancies
100 Clinical Results associated with LP-118
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100 Translational Medicine associated with LP-118
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100 Patents (Medical) associated with LP-118
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1
Literatures (Medical) associated with LP-118Haematologica
LP-118 is a novel B-cell lymphoma 2 / extra-large inhibitor that demonstrates efficacy in models of venetoclax-resistant chronic lymphocytic leukemia
Article
Author: Perry, Elizabeth ; Shen, Yue ; Diaz-Rohena, Daisy Y ; Ravikrishnan, Janani ; Bhat, Seema A ; Anthony, Stephen P ; Chen, Yi ; Chen, Yu ; Wierda, William G ; Satpati, Suresh ; Lapalombella, Rosa ; Misra, Shrilekha ; Mitchell, Andrew ; Woyach, Jennifer A ; Sampath, Deepa ; Davids, Matthew S ; Mo, Xiaokui ; Lozanski, Arletta ; Rogers, KerryA ; Sanchez, John ; Lai, Tzung-Huei ; Kittai, Adam S ; Kaufman, Tierney ; Lozanski, Gerard ; Williams, Charmelle D ; Collins, Mary C ; Jain, Nitin ; Liu, Chaomei ; Byrd, John C ; Tan, Fenlai ; Muhowski, Elizabeth
100 Deals associated with LP-118
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Acute Lymphoblastic Leukemia | Phase 1 | US | 23 Aug 2021 | |
| Blast Phase Chronic Granulocytic Leukemia | Phase 1 | US | 23 Aug 2021 | |
| Chronic lymphocytic leukaemia refractory | Phase 1 | US | 23 Aug 2021 | |
| Chronic Myelomonocytic Leukemia | Phase 1 | US | 23 Aug 2021 | |
| Multiple Myeloma | Phase 1 | US | 23 Aug 2021 | |
| Myelodysplastic Syndromes | Phase 1 | US | 23 Aug 2021 | |
| Myelofibrosis | Phase 1 | US | 23 Aug 2021 | |
| Small Lymphocytic Lymphoma | Phase 1 | US | 23 Aug 2021 | |
| T-Cell Prolymphocytic Leukemia | Phase 1 | US | 23 Aug 2021 | |
| Timothy Syndrome | Phase 1 | US | 23 Aug 2021 |
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