ISM-3412

The primary purpose of this trial is to evaluate the safety and tolerability of ISM3412 in subjects with locally advanced/metastatic solid tumors and to determine the recommended Phase II dose of ISM3412 in subjects with locally advanced/metastatic solid tumors. The secondary purpose of this trial is to evaluate the preliminary efficacy of ISM3412 in subjects with locally advanced/metastatic solid tumors and to evaluate the pharmacokinetic characteristics of ISM3412 after single and multiple doses. The exploratory purpose of this trial is to explore the metabolites of ISM3412 and evaluate the pharmacodynamic characteristics of ISM3412.