Delving into the Latest Updates on RBD-PapMV with Synapse

Overview

Basic Info

Drug Type

Prophylactic vaccine

Synonyms-

Target

Mechanism

SARS-CoV-2 S protein inhibitors(Coronavirus spike glycoprotein inhibitors), TLR7 modulators(Toll like receptor 7 modulators), TLR8 modulators(Toll like receptor 8 modulators)

Therapeutic Areas

Infectious Diseases

Active Indication

Coronavirus Infections

Inactive Indication-

Originator Organization

Université Laval

Active Organization

Université Laval

Inactive Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

Author: Flamand, Louis ; Farnòs, Omar ; Olivera-Ugarte, Santa-Mariela ; Baz, Mariana ; Dubuc, Isabelle ; Couture, Christian ; Fillion, Maude ; Gilbert, Mégan ; Bolduc, Marilène ; Kamen, Amine ; Blanchette, Léa-Jeanne ; Scarrone, Martina ; Garneau, Caroline ; Savard, Pierre ; Leclerc, Denis ; Laliberté-Gagné, Marie-Ève ; Xu, Xingge ; Rabezanahary, Henintsoa

A vaccine candidate to SARS-CoV-2 was constructed by coupling the viral receptor binding domain (RBD) to the surface of the papaya mosaic virus (PapMV) nanoparticle (nano) to generate the RBD-PapMV vaccine. Immunization of mice with the coupled RBD-PapMV vaccine enhanced the antibody titers and the T-cell mediated immune response directed to the RBD antigen as compared to immunization with the non-coupled vaccine formulation (RBD + PapMV nano). Anti-RBD antibodies, generated in vaccinated animals, neutralized SARS-CoV-2 infection in vitro against the ancestral, Delta and the Omicron variants. At last, immunization of mice susceptible to the infection by SARS-CoV-2 (K18-hACE2 transgenic mice) with the RBD-PapMV vaccine induced protection to the ancestral SARS-CoV-2 infectious challenge. The induction of the broad neutralization against SARS-CoV-2 variants induced by the RBD-PapMV vaccine demonstrate the potential of the PapMV vaccine platform in the development of efficient vaccines against viral respiratory infections.

100 Deals associated with RBD-PapMV

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