The paper describes the effects of the new nootropic agents nooglutyl and glycine N-phenyl-L-prolyl ethyl ester (GVS-111). Nooglutyl, a derivative of L-glutamic and oxynicotinic acids, that has glutamatergic effects is a highly active drug in treating disturbances of memory and learning, protecting against ischemic neuronal damage and brain injury. GVS-111 is a substituted prolyl dipeptide that has the properties of enhancing cognitive functions and is able to prevent the learning impairment provoked by shock, scopolamine, brain injury, and other damages. Multimodal mechanisms responsible for the nootropic effects of nooglutyl and GVS-111.

01 Jan 1998·Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine

[Pharmacological treatment of memory disorders caused by hypoxia and cerebral ischemia in rats].

Article

Author: Krylova, I N ; Provornova, N A ; Iasnetsov, V V

Experiments with white mongrel rats (both females and males) showed that nootropic substances, i.e. sodium hydroxybutyrate, pyracetam, oxyracetam, aniracetam, centrophinoxine, nooglutyl, mexydol, semax, amide L-pyroglutamyl-D-alanine, and MK-801, a specific noncontesting antagonist of the NMDA-receptor complex, significantly increased survivability of the animals following bilateral occlusion of the common carotid arteries. The nootrops prevented, partly or completely, mnestic disorders in the experimental rats. In contrast, MK-801 profoundly aggravated these disorders. Similar results were obtained with a model of hypoxic amnesia. Except for N-acetylglycine amide and amide L-pyroglutamyl-D-alanine, the nootrops fully or to a considerable extent blocked the development of mnestic disorders in hypoxic rats. The authors recommend novel nootrops (nooglutyl, mexidol, semax and GVS-111) for the pharmacological correction of mnestic disorders consequent to hypoxia or cerebral ischemia.

Eksperimental'naia i klinicheskaia farmakologiia

[Effect of nooglutyl on the behavior and memory of SAMP10 mice with genetically determined accelerated aging].

Article

Author: Grigor'ev, V V ; Litvinova, S A ; Bachurin, S O ; Garibova, T L ; Voronina, T A

It is established that SAMP10 mice (senescence-accelerated mice prone 10) with genetically determined accelerated senescence at an age of 9-month exhibit (in comparison to 3-month animals of the same strain) the behavior and memory deficits typical of aged animals, namely, reduced locomotor activity elevated anxiety, and disturbances of memory trace retrieval. Nooglutyl in a dose of 20 mg/kg produces a positive effect on the behavior and memory of 9-month old SAMP10 mice. The observed improvements include optimization of the locomotor activity in the open field test, diminished anxiety in elevated plus maze test, and improved retrieval of passive avoidance reflex.

100 Deals associated with Nooglutyl

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Indication	Highest Phase	Country/Location	Organization	Date
Cognition Disorders	Preclinical	-	Russian Academy of Medical Sciences	-

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