Last update 04 Nov 2025

DEG-6498

Overview

Basic Info

Drug Type
Molecular glue
Synonyms
ELAVL1 (Degron Therapeutics), ELAVL1 (达歌生物), DEG 6498
+ [1]
Target
ELAVL1
Action
inhibitors
Mechanism
ELAVL1 inhibitors(ELAV like RNA binding protein 1 inhibitors)
Therapeutic Areas
NeoplasmsNervous System DiseasesDigestive System Disorders+ [1]
Active Indication
Advanced Malignant Solid NeoplasmSolid tumor by SiteColorectal Cancer+ [2]
Inactive Indication-
Originator Organization
Degron Therapeutics Co. Ltd.Degron Therapeutics Co. Ltd.
Active Organization
Degron Therapeutics Co. Ltd.Degron Therapeutics Co. Ltd.Hangzhou Dago Biomedical Technology Co., Ltd.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with DEG-6498
CTR20254261
/ Not yet recruitingPhase 1
DEG6498 在实体瘤患者中的首次人体 I 期开放标签、多中心、剂量递增及扩展研究
[Translation] First-in-human, open-label, multicenter, dose-escalation and expansion study of DEG6498 in patients with solid tumors.
100 Clinical Results associated with DEG-6498
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100 Translational Medicine associated with DEG-6498
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100 Patents (Medical) associated with DEG-6498
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100 Deals associated with DEG-6498
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 1
China
Hangzhou Dago Biomedical Technology Co., Ltd.
04 Nov 2025
Solid tumor by SitePhase 1
United States
Degron Therapeutics Co. Ltd.Degron Therapeutics Co. Ltd.
-
Colorectal CancerPreclinical
China
Degron Therapeutics Co. Ltd.Degron Therapeutics Co. Ltd.
31 May 2024
GlioblastomaPreclinical
China
Degron Therapeutics Co. Ltd.Degron Therapeutics Co. Ltd.
31 May 2024
Hepatocellular CarcinomaPreclinical
China
Degron Therapeutics Co. Ltd.Degron Therapeutics Co. Ltd.
31 May 2024
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Clinical Result

Indication
Phase
Evaluation
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Phase
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Deal

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Clinical Trial

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Approval

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Regulation

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