Compound Glycyrrhizin

1. Case presentationA 4‐month‐old female infant was admitted to our clinical ward in May 2021 due to her skin manifestation of the jaundice since birth. Her symptoms aggravated progressively despite various medications (e.g. Ursodeoxycholic Acid, Stronger Neo‐Minophagen C Tablets) were prescribed. Initial Work‐up. The admission abdominal ultrasound demonstrated contracted gallbladder, with no sign of common bile duct. Two weeks ago, she was admitted into Pediatric ICU, where her conditions worsened to coagulation dysfunction, digestive tract hemorrhage and hypotension. Diagnosis and Management. With initial work‐ups, the patient was diagnosed with congenital biliary atresia, liver cirrhosis, respiratory failure secondary to severe pneumonia (aspergillus and mycoplasma infections), secundum atrial septal defect (ASDII, 9.7mm) and hypoalbuminemia. Accordingly, CPAP‐assisted ventilation, injections of meropenem, vancomycin, and carprofen, as well as IVIG (2g/kg) and vitamin K1 were admitted. Echocardiogram confirmed pulmonary artery hypertension (PAH), right atrial enlargement, and portal hypertension. Further, she exhibited right heart failure (HF) symptoms, such as abdominal effusion, lower extremity edema. An urgent percutaneous ASD closure was scheduled prior to the parent‐to‐offspring liver transplantation, thereby reducing the high risk of right HF and PAH during the surgery.2. Surgical proceduresBriefly, a venous access was probed in groin area under local anesthesia (1% lidocaine). Upon bleeding, a 6F venous sheath tube (FAST‐CATHTM, ST.JUDE Medical) was gently inserted into the right femoral vein, followed by a Cordis MPA catheter (Cordis 6F, Johnson & Johnson Inc), which was further threaded through the vessel into heart. Once MPA catheter reached the left superior pulmonary vein through ASD, we released the guidewire and retracted the venous sheath tube simultaneously. (Fig. 1) Next, we inserted a 9F delivery sheath tube to transport the 10mm MemoPart™ ASD Occluder (FQFDQ‐I 10, SHSMA Corp) into anatomical left atrium through the interatrial hole. Once the umbrella at both atrial sides was released consecutively forming a sandwich‐like skeleton, the closure was successfully completed along with retraction of the occluder. (Fig.2)3. Follow‐upOne week after ASD closure, she received a living‐donor liver transplantation, and her liver function returned to normal shortly, with no further cirrhosis‐associated complications. Before discharge, echocardiogram demonstrated no shunt exist. (Fig.3)4. DiscussionStatistically, 15.8% of liver‐transplant recipients are having cardiovascular diseases, among whom 30% are diagnosed with ASD.Most children with ASD remain asymptomatic and their physical activities are typically unaffected till adolescence. Congestive HF and PAH will occur in patients with medium‐to‐large ASD around the age of 20‐30 years. In our case, the child was very young, yet with an extremely complicated condition requiring multiple resuscitation procedures. The large left‐to‐right shunt volume in the 9.7mm ASD was further exacerbated by heavy fluid loads formed during the rescues. Thus, transcatheter ASD occlusion was performed before liver transplantation to effectively manage the hemodynamic stability in perioperative period.

Riehl's melanosis is a chronic, refractory disorder, which can adversely affect patient's quality of life. Intense pulse light, neodymium‐doped yttrium aluminum garnet laser, hydroquinone, tranexamic acid have been reported to treat this disease, but there have been few reports on the effectiveness of other treatments.

To assess the efficacy and safety of triple combination therapy with salicylic acid chemical peels, oral glycyrrhizin compound, and vitamin C for Riehl's melanosis.

Three patients diagnosed with Riehl's melanosis were enrolled. All patients were treated with glycyrrhizin compound (150 mg/d), vitamin C (100 mg/d), and salicylic acid 30% peels once every 2 weeks. Clinical photographs and VISIA were used to assess the efficacy.

All patients received obvious improvement and reported no obvious side effects.

Triple combination therapy with salicylic acid peels, oral glycyrrhizin compound, and vitamin C is a safe and effective modality for Riehl's melanosis.