AbstractThe failure of bone regeneration has been considered as a serious problem that troubling patients for decades, most of which was resulted by the poor angiogenesis and chronic inflammation after surgery. Among multiple materials applied in the repair of bone defect, silicate bioceramics attracted researchers because of its excellent bioactivity. The purpose of this study was to detect the effect of specific bioactive glass ceramic (AP40, based on crystalline phases of apatite and wollastonite) on angiogenesis and the subsequent bone growth through the modulation of macrophages. Two groups were included in this study: control group (macrophages without any stimulation, denominated as Control) and AP40 group (macrophages incubated on AP40). This study investigated the effect of AP40 on macrophages polarization (RAW264.7) and angiogenesis in vitro and in vivo. Additionally, the changes of angiogenic ability regulated by macrophages were explored. AP40 showed excellent angiogenesis potential and the expression of CD31 was promoted through the modulation of macrophages toward M2 subtype. Additionally, the macrophages incubated on AP40 synthesized more PDGF‐BB comparing to macrophages without any stimulation, which contributed to the improved angiogenetic ability of human umbilical vein endothelial cells (HUVECs). Results of in vivo studies indicated increased bone ingrowth along the implants, which indicated the potential of bioceramics for bone defect repair clinically.

01 Jul 2020·OdontologyQ3 · MEDICINE

Glass coatings to enhance the interfacial bond strength between veneering ceramic and zirconia

Q3 · MEDICINE

Article

Author: Cerda-Cristerna, Bernardino Isacc ; Sánchez-Vargas, Luis Octavio ; Pozos-Guillen, Amaury ; Silva-Herzog Rivera, Daniella ; Aragón-Piña, Antonio ; Masuoka-Ito, David

The purpose of this study was to investigate the tensile bond strength (TBS) and shear bond strength (SBS) between a zirconia core and fluoroapatite-pressed ceramic after the application of glass 46SP6 and AP40 via the ISO-17095:2013 methodology. Sintered zirconia beams (n = 120) were divided into four groups: (a) control: no treatment; (b) ZirL: IPS-E max ceram ZirLiner coating; (c) glass AP40 coating; and (d) glass 46SP6 coating. A fluoroapatite ceramic (IPS e.max Zir Press, Ivoclar Vivadent) beam was injected perpendicularly on top of each zirconia (Zenostar, Wieland Dental) beam forming a cross-bonded specimen. All groups were sub-divided into two for tensile and shear bond strength tests using a universal testing machine. Data were analyzed using the Kruskal-Wallis, Pearson Chi²_, and Mann-Whitney U test (α = 0.05). The failure modes were measured using a stereomicroscope for each group. Scanning electron and atomic force microscopy were also employed. Zirconia surface modification with glass AP40 showed higher TBS values followed by the ZirL group with statistical differences (p < 0.05). SBS values showed no statistical differences between the groups. AFM analysis showed higher roughness values (Ra) in the 46SP6 and AP40 groups (p < 0.05). Glass coating AP40 exhibited promising bond strength results between zirconia and fluorapatite veneering ceramic, making it better for chemical and mechanical interlocking which may improve bilayered restorations longevity.

01 Sep 2007·Journal of Biomedical Materials Research Part AQ3 · ENGINEERING & TECHNOLOGY

Biomaterials for orthopedics: A roughness analysis by atomic force microscopy

Q3 · ENGINEERING & TECHNOLOGY

Article

Author: Lorenza Spotorno ; Luca Giacomelli ; Claudio Nicolini ; Patrizia Loria ; Ugo Covani ; Adriano Krajewski ; Antonio Ravaglioli ; Saradindu Das

AbstractWe conducted an AFM analysis of roughness on 7 materials widely used in bone reconstruction. Roughness was evaluated by measuring Root Mean Square (RMS) values and RMS/average height (AH) ratio, in different dimensional ranges, varying from 100 microns square to a few hundreds of nanometers. The results showed that Titanium presented a lower roughness than the other materials analyzed, frequently reaching statistical significance. On the contrary, bioactive materials, such as hydroxyapatite (HA) and bioactive glasses, demonstrated an overall higher roughness. In particular, this study focuses attention on AP40 and especially RKKP, which proved to have a significant higher roughness at low dimensional ranges. This determines a large increase in surface area, which is strongly connected with osteoblast adhesion and growth and to protein absorption. Therefore, the biointegration properties of bioactive glasses can also be given as answer in terms of surface structures in which chemical composition can influence directly the biological system (e.g. with chemical exchanges and development of specific surface electrical charge) and indirectly, via the properties induced on tribological behavior that expresses itself during the smoothing of the surfaces. We also test two new bioactive glasses, RBP1 and RBP2, with a chemical composition similar to AP40, but with some significant small additions and substitutions of components, in order to make preliminary considerations on their potential role in orthopedics. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2007

100 Deals associated with AP-40 (Aprogen)

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Triple Negative Breast Cancer	Preclinical	KR	Aprogen, Inc.	16 Aug 2023

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

AP-40 (Aprogen)

Overview

Basic Info

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation