Delving into the Latest Updates on Tau targeting therapeutics and diagnostics(TauRx Pharmaceuticals) with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

G3

Target

TAU

Action

inhibitors

Mechanism

TAU inhibitors(Microtubule-associated protein tau inhibitors)

Therapeutic Areas

Nervous System Diseases

Active Indication-

Inactive Indication

Alzheimer Disease

Originator Organization

TauRx Pharmaceuticals Ltd.

Active Organization-

Inactive Organization

TauRx Pharmaceuticals Ltd.

Drug Highest PhasePendingPreclinical

First Approval Date-

Regulation-

The aim of this study was to report the corneal densitometry (CD) evolution studied by Scheimpflug tomography, anterior segment optical coherence tomography (AS-OCT), and confocal microscopy changes, in patients with advanced keratoconus included in a clinical experience of advanced cell therapy using autologous humans adipose-derived adult stem cells (ADASCs) and corneal decellularized and ADASCs-recellularized human donor corneal laminas.

Methods::

This study is an interventional prospective, consecutive, randomized, comparative series of cases. Fourteen patients with keratoconus were randomly distributed into 3 groups for 3 types of surgical interventions: group 1 (G-1), autologous ADASC implantation (n = 5); group 2 (G-2), decellularized human corneal stroma (n = 5); and group 3 (G-3), autologous ADASCs + decellularized human corneal stroma (n = 4). Participants were assessed with Scheimpflug-based Oculus Pentacam CD module, AS-OCT (Visante; Carl Zeiss), and confocal microscopy (HRT3 RCM Heidelberg).

Results::

A significant improvement of 1 to 2 logMAR lines in all visual parameters in the 3 groups was obtained. The central and total CD were statistically significantly higher in G-2 compared with G-1 and G-3 compared with G-1 at the studied annular zones centered on the corneal apex (0–2, 2–6, and 6–10 mm). There was statistical significance higher in G-3 compared with G-2 at the central corneal stroma at 0–2 and 2–6 mm. The confocal microscopy findings and the AS-OCT reflected the densitometry changes.

Conclusions::

The intrastromal implantation of ADASCs produced very subtle changes in CD at the level of the central corneal stroma. However, the intrastromal implantation of decellularized corneal laminas increases it slightly, but with lower values than the implantation of recellularized laminas with ADASCs.

01 May 2020·American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of OrthodonticsQ2 · MEDICINE

Skeletal effects of monocortical and bicortical mini-implant anchorage on maxillary expansion using cone-beam computed tomography in young adults

Q2 · MEDICINE

Article

Author: Dong, Weiji ; Guo, Jing ; Li, Qiming ; Sun, Wenqian ; Martin, Domingo ; Li, Na

INTRODUCTION:

This study aimed to evaluate and compare the skeletal effects of monocortical and bicortical mini-implant anchorage on maxillary skeletal expansion (MSE) using cone-beam computed tomography in young adults.

METHODS:

The sample comprised 48 patients (aged 19.4 ± 3.3 years; 19 male, 29 female) treated with maxillary skeletal expander and was divided into 3 groups according to insertion pattern of mini-implants used. G1, 4-all-bicortical penetration (n = 17); G2, 2-rear-bicortical penetration (n = 17); G3, non-4-bicortical penetration (n = 14). Cone-beam computed tomography scans were taken before treatment and 3 months after activation.

RESULTS:

The transverse width of maxilla, nasal bone, lateral pterygoid plate, zygomatic bone, and temporal bone increased similarly in G1 and G2. Contrarily, G3 produced less skeletal expansion, having no effects on the temporal bone. Significant increases in width were seen in all 3 groups regarding transverse dentolinear measurements. A triangular expansion pattern was also observed, but G1 and G2 showed more parallel expansion than G3. In addition, G1 and G2 showed less inclination of anchorage teeth compared with G3. The loss of vertical alveolar bone, although only in a small amount, was observed in all groups.

CONCLUSIONS:

MSE with non-4-bicortical penetration produced fewer orthopedic effects and more unwanted dentoalveolar side effects, whereas MSE with 2-rear-bicortical and 4-all-bicortical penetration showed similar skeletal effects, which means that 2-rear-bicortical penetrating mini-implants were critical to skeletal expansion.

01 Nov 2019·Fish & shellfish immunologyQ2 · AGRICULTURAL & FORESTRY SCIENCE

Preliminary screening and immunogenicity analysis of antigenic epitopes of spring viremia of carp virus

Q2 · AGRICULTURAL & FORESTRY SCIENCE

Article

Author: Guo, Zi-Rao ; Gong, Yu-Ming ; Wang, Gao-Xue ; Zheng, Yu-Ying ; Zhang, Chen ; Yang, Ben ; Zhu, Bin

Glycoprotein (G) is the most common gene used in SVCV vaccine constructions. To identify the major immunogenicity determinant region of SVCV G gene, herein we truncated G gene to 4 parts (G-1, G-2, G-3 and G-4). Bioinformatics and the enzyme linked immunosorbent assay (ELISA) were used to identify the antigenicity of these 4 truncated G proteins. Immunological assays (serum antibody production, enzyme activity, immune genes expression and challenge test) were carried out to further identify the immunogenicity of the screened G protein in common carp. Moreover, to further verify the immune response of the screened G protein-based subunit vaccine, its protective effects on common carp against SVCV infection using single-walled carbon nanotubes (SWCNTs) as a carrier were evaluated. Results showed that G-3 protein could induce higher antibody titer than other truncated G proteins. Furthermore, carps vaccinated with G-3 and G (positive control) showed significant enhancement of immune response (serum antibody production, enzyme activity and immune related genes expression) when compared with control groups. Meanwhile, as a promising vaccine carrier, SWCNTs could significantly enhance the immune effect of naked subunit vaccine (G-3 and G). Notably, after SVCV challenge, there was no significant difference in immune protection between G-3 and G, nor between SWCNTs-G-3 and SWCNTs-G. These results so far suggest G-3 might be the potential antigen epitope of SVCV. This study lays a foundation for developing vaccine and immunodiagnostic techniques.

100 Deals associated with Tau targeting therapeutics and diagnostics(TauRx Pharmaceuticals)

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