Chlordiazepoxide-amitriptyline (Limbitrol) has been shown to be more rapidly effective than amitriptyline alone for treating depression. A double-blind, randomized study was designed to compare the effects of Limbitrol and amitriptyline on insomnia, anxiety, and depression. The rate of improvement of symptoms was faster with Limbitrol. No differences were noted between groups in the degree or rate of improvement of the sleep laboratory parameters nor in sleep Stages 1 to 4. Percentages of rapid eye movement (REM) sleep and REM latency were similarly affected by the drugs, but REM density showed a significantly greater decrease with Limbitrol. Phasic REM factors may be crucial in the role of REM sleep and depression.

01 Mar 1985·Journal of International Medical ResearchQ4 · MEDICINE

Comparison of Limbitrol (Chlordiazepoxide/Amitriptyline) and Amitriptyline Alone as a Single Night-Time Dose for the Treatment of Depression with Anxiety

Q4 · MEDICINE

ArticleOA

Author: James, R T D ; Dean, B C

Four hundred and thirty-four patients suffering from mild to moderate depression were recruited into a double-blind multicentre general practice study and randomly received either Limbitrol (25 mg amitriptyline and 10 mg chlordiazepoxide) or amitriptyline 25 mg in matching white capsules given as a single night-time dose. The dose was titrated to a maximum of four capsules per night. Patients were assessed on entry and at 7-day intervals for depressive state (Hamilton Rating Scale for Depression), cardiovascular effect and side-effects for 28 days. Self-assessments of depression and anxiety using the Leeds Scale were made in the form of a patient questionnaire. Both groups showed significant improvement at each visit and significantly more patients improved after 7 days in the Limbitrol group. There was no significant difference in treatment over all between groups, in the incidence of side-effects, or in the effects on the heart.

01 Jan 1984·NeuropsychobiologyQ4 · PSYCHOLOGY

Single Case Experiments in Psychopharmacological Trials

Q4 · PSYCHOLOGY

Article

Author: Klieser, Eckart ; Wolfrum, Christine ; Lehmann, Erlo

Single case experiments have been used to make pharmacotherapeutic decision making more objective. 4 single case experiments are presented. In the case of 3 patients the question was whether flunitrazepam (Rohypnol) should be administered. In the 4th patient the issue was whether self-administration of Limbitrol (amitriptyline + chlordiazepoxide) should be terminated. Planning and analysis of these experiments was carried out by the randomization test.

100 Deals associated with Amitriptyline Hydrochloride/Chlordiazepoxide

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