Hemay007

This study adopts a multicenter, randomized, double-blind, low-medium-high dose group and placebo parallel controlled clinical study design. After screening, patients with active ulcerative colitis who meet the inclusion criteria and do not meet the exclusion criteria will be randomized by 1:1:1:1 to Hemay007 400 mg BID group, 800 mg QD group, 600 mg BID group or placebo group, with proposed 72 cases in each group. After 12 weeks of double-blind inductive treatment period, the patients will enter the Hemay007 open treatment period of 12 weeks when Hemay007 600 mg BID will be used as the medication regimen. All randomized subjects who have received the investigational drug should be subjected to a 4-week observation after the end of treatment.

主要目的：与安慰剂相比，探索不同剂量给药方案的Hemay007用于活动性溃疡性结肠炎的有效性及剂量效应关系； 次要目的：与安慰剂相比，评价不同剂量给药方案的Hemay007用于活动性溃疡性结肠炎的安全性。 观察Hemay007在溃疡性结肠炎患者中的群体药代动力学特征。