Last update 26 Oct 2025

HDBNJ-2812

Overview

Basic Info

Drug Type
Proteolysis-targeting chimeras (PROTAC)
Synonyms
HDBNJ 2812, HDBNJ2812
Target
EGFR C797S x EGFR L858R x EGFR T790M x EGFR-Ex19del
Action
degraders
Mechanism
EGFR C797S degraders(Epidermal Growth Factor Receptor C797S degraders), EGFR L858R degraders(EGFR exon 21 L858R mutation degraders), EGFR T790M degraders(Epidermal Growth Factor Receptor T790M degraders)
Therapeutic Areas
NeoplasmsRespiratory Diseases
Active Indication
EGFR C797S Mutation Non-small Cell Lung Cancer
Inactive Indication-
Originator Organization
Handok, Inc.Handok, Inc.
Active Organization
Biopharma Co. Ltd.Handok, Inc.Handok, Inc.Yonsei University College of Medicine
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Related

100 Clinical Results associated with HDBNJ-2812
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100 Translational Medicine associated with HDBNJ-2812
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100 Patents (Medical) associated with HDBNJ-2812
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100 Deals associated with HDBNJ-2812
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
EGFR C797S Mutation Non-small Cell Lung CancerPreclinical
South Korea
Biopharma Co. Ltd.
22 Mar 2024
EGFR C797S Mutation Non-small Cell Lung CancerPreclinical
South Korea
Yonsei University College of Medicine
22 Mar 2024
EGFR C797S Mutation Non-small Cell Lung CancerPreclinical
South Korea
Handok, Inc.Handok, Inc.
22 Mar 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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