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Last update 08 May 2025

Dicalcium phosphate

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target-

Action-

Mechanism

Calcium supplements

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaCaH3O4P

InChIKeyUUVBYOGFRMMMQL-UHFFFAOYSA-N

CAS Registry7757-93-9

100 Clinical Results associated with Dicalcium phosphate

100 Translational Medicine associated with Dicalcium phosphate

100 Patents (Medical) associated with Dicalcium phosphate

41,929

Literatures (Medical) associated with Dicalcium phosphate

31 Dec 2025·Italian Journal of Animal Science

Effect of monobutyrate on growth performance, intestinal development, and cecum microbiota in broilers

Author: Yang, Minghua ; Li, Yongneng ; Qiu, Wencai ; Zhao, Sumei ; Tai, Yuan ; Huang, Ying ; Pan, Hongbin ; Liu, Chen

The prohibition of antibiotic growth promoters for animal production has created a demand to explore alternative feed additives to replace antibiotics.Monobutyrate has the potential to replace antibiotics.In this study, we investigated the effects of monobutyrate on broiler growth performance, intestinal development, and caecum microbiota.Total 240 1d-old Arbor Acres broilers were randomly divided into five groups.Each group had eight broilers, and the groups were replicated six times.The broilers were fed a basal diet (CK group), a basal diet containing 0.1% acetyl kitasamycin (Anti group), and basal diets containing 0.15‰, 0.30‰, and 0.45‰ monobutyrate (M1, M2 and M3 group) for 42 days.Compared with the CK group, F/G was significantly decreased in broilers in the M3 group (p <0.05).The relative length and weight of the duodenum were significantly higher in the M1, M2, and M3 groups than those in the CK group.Compared with the CK group, the relative ileum length was significantly increased in the M2 and M3 groups (p <0.05).Compared with those of the CK and Anti groups, Rikenellaceae, Alistipes, Sellimonas, and Ruminococcus_2 were enriched in the M3 group (p < 0.05).The results of this study indicated that monobutyrate promotes broiler growth performance, improves intestinal development, and regulates microbiota composition

31 Dec 2025·Energy Sources, Part A: Recovery, Utilization, and Environmental Effects

Employing sulfur–phosphorus mixed acid as a depressant: a novel investigation in flotation of collophanite

Author: Zhang, Hanquan ; Jin, Yanfeng ; Zhou, Feng ; Liu, Mingxia ; Yu, Hong ; Xiao, Linbo

Inorganic acids (sulfuric acid (H₂SO₄) or phosphoric acid (H₃PO₄)) are generally employed as depressants in the reverse flotation of collophanite to sep. apatite from dolomite.In this study, the flotation performance of a collophanite ore was studied, employing H₂SO₄, H₃PO₄, and a sulfur-phosphorus mixed acid as the depressants.The flotation tests revealed that the sulfur-phosphorus mixed acid could depress the apatite effectively.A high-quality concentrate with P₂O₅ content of 28.4 wt% and MgO content of 0.95 wt% was obtained, the corresponding P₂O₅ recovery of which was 85.0%.Furthermore, the separation mechanism of apatite and dolomite was clarified by zeta potential measurements, solution chem. anal. and XPS.Within the pH range of 4.0-7.0, the zeta potentials of apatite were neg. while those of dolomite were pos. in the presence of all the three acid-depressants.The addition of sodium oleate made the potentials of both minerals to a more neg. position.However, the potential shifts of dolomite were much more significantly neg. than apatite when H₂SO₄ or H₃PO₄ was used.It indicated a greater absorption of sodium oleate on the surface of dolomite than apatite, which contributed to a more widen hydrophobicity gap between the surfaces of apatite and dolomite.SO₄^2- and H₂PO₄^-, not H⁺ or Cl^-, were founded to be the pivotal ions for depressing.XPS analyses illustrated that the simultaneous additions of H₂SO₄ and H₃PO₄ as depressants were beneficial to the formation of CaHPO₄ and CaSO₄ on the surface of the apatite, which were harmful for the adsorption of sodium oleate, making the depressing effect more remarkable and result in a better separation of dolomite from apatite.It performed much more efficiently in collophane ore flotation when H₃PO₄ and H₂SO₄ were used corporately as a combined depressant than when they were used sep.

01 Aug 2025·Biomaterials

A Di-aptamer-functionalized scaffold promotes bone regeneration by facilitating the selective retention of MSCs and EPCs and then promoting crosstalk between osteogenesis and angiogenesis

Article

Author: Yang, Qiandong ; Hou, Tianyong ; Yang, Ming ; Tang, Zhenzhen ; Zhou, Jiangling ; Gui, Yingtao ; Yu, Bo ; He, Sihao ; Cai, Juan ; Dai, Qijie ; Wei, Jiayi ; Yang, Fan

The crosstalk between osteogenesis and angiogenesis plays an important role in promoting the formation of a microenvironment that supports bone regeneration. This suggests that the retention of endogenous osteogenic and angiogenic cells in the bone defect area can promote tissue-engineered bone (TEB) osteogenesis and cell-cell interactions. In this study, a Di-Aptamer-functionalized HA/β-TCP (Di-Aptamer-H/T) scaffold was prepared by sequential modification of APTES and sulfo-SMCC and connected with aptamer HM69 and EPC1. We confirmed that aptamers HM69 and EPC1 can specifically identify mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), respectively. This process triggers the expression of adhesion-related genes in these cells and allows these cells to selectively stay coupled to Di-Aptamer-H/T. The osteogenic differentiation ability of MSCs treated with Di-Aptamer-H/T in vitro was significantly increased. Similarly, the ability of Di-Aptamer-H/T-treated EPCs to form blood vessels was also enhanced. Notably, the osteogenic and angiogenic abilities of cocultured MSCs and EPCs treated with the Di-Aptamer-H/T scaffold were significantly better than those of cells cultured individually. In vivo, the results of micro-CT angiography, H&E staining, Masson's staining and histochemical staining further confirmed that Di-Aptamer-H/T formed new bones and vessels more readily than those treated with a single aptamer linked to HA/β-TCP or with HA/β-TCP alone. In brief, our study demonstrated that crosstalk between osteogenesis and angiogenesis is promoted by the Di-Aptamer-H/T scaffold, which serves as a potential treatment strategy for bone defects and can improve outcomes.

100 Deals associated with Dicalcium phosphate

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