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Last update 08 May 2025

Carbendazole

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Cambendazole

Target-

Action-

Mechanism-

Therapeutic Areas

Infectious DiseasesSkin and Musculoskeletal Diseases

Active Indication

OnychomycosisTineaTinea Pedis

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC14H14N4O2S

InChIKeyQZWHWHNCPFEXLL-UHFFFAOYSA-N

CAS Registry26097-80-3

100 Clinical Results associated with Carbendazole

100 Translational Medicine associated with Carbendazole

100 Patents (Medical) associated with Carbendazole

324

Literatures (Medical) associated with Carbendazole

01 Sep 2024·Journal of Food Composition and Analysis

Determination of 24 Benzimidazoles in meat and meat products by modified QuEChERS coupled with UPLC-MS/MS

Author: Guo, Erling ; Lian, Kaoqi ; Wang, Menglin ; Wang, Ke ; Zhang, Hong ; Yin, Xirong ; Qiao, Yan

In this study, an effective method for the simultaneous determination of 24 Benzimidazoles in meat and meat products based on a modified QuEChERS sample preparation technique coupled with ultra-performance liquid chromatog.-tandem mass spectrometry was established.Then, BZDs in meat and meat products were extracted by 0.1 % ammonium hydroxide in acetonitrile, followed by cleanup with 0.1 g C₁₈ and 0.3 g MgSO₄, ionized in electrospray pos. ionization source mode, and scanned for determination of the precursor ion and product ion by mass spectrometry in multiple reaction monitoring mode.The results showed that 24 BZDs had good linearity in the range of 0.2-100 μg/kg with correlation coefficients >0.999, and the limits of detection ranged from 0.001 to 0.244 μg/kg and the limits of quantification were between 0.002 and 0.738 μg/kg.The average recoveries of BZDs at three different spike levels of 2, 20, and 50 μg/kg were 74.6 % -113.9 %, with intra-day and inter-day relative standard deviations less than 9.86 % and 11.03 %, resp.This method has been successfully applied to the determination of BZDs in real samples, providing a powerful tool for the monitoring of BZDs residues in animal-derived foods.

01 Jun 2024·Food Chemistry

One step cleanup of 160 pesticides and veterinary drugs in aquatic products using melamine-based automatic pressure filtration purification method combined with HPLC-MS/MS

Article

Author: Wen, Yupeng ; Huang, Dongmei ; Zhang, Chaoying ; Sun, Huiwu ; Yang, Guangxin ; Zhou, Ruidong ; Kong, Cong ; Huo, Wendi ; Liu, Huan ; Li, Jincheng

A 15-channel pressure filtration purification method was presented for high throughput sample preparation of aquatic products. A cost-effective device was constructed and melamine sponge was selected as the cleanup sorbent. Upon interfacing with HPLC-MS/MS, the analytical procedure demonstrated its suitability for quantifying 160 pesticides and veterinary drug residues in aquatic products such as fish, shrimp, and crab. The method achieved sample recoveries ranging from 61.3 to 124.9 %. The detection limits were established between 0.5 and 1.0 μg/kg, while the quantitation limits were confirmed to be within the range of 1.0-2.0 μg/kg. The method was applied to quantify the pesticide and veterinary drug residues in mostly consumed aquatic products from five coastal provinces in China. The results showed significant differences between different aquatic products in the concentrations of pesticide and veterinary drug residues, implying the necessity of supervision for the accurate determination of pesticides and veterinary drugs.

01 Feb 2024·Journal of Analytical Chemistry

Sample Screening and Determination of 214 Veterinary Drug Residues in Food Using Chromatography–High-Resolution Mass Spectrometry

Author: Tretyakov, A. V. ; Batov, I. V. ; Amelin, V. G. ; Kish, L. K. ; Lavrukhina, O. I.

AbstractA combination of sample screening and subsequent confirmatory detection of contaminants represents an optimal strategy for routine analysis in implementing food safety monitoring programs. We propose ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry for the multicomponent determination of a wide range of veterinary drugs and their metabolite residues with minimal sample preparation. Isotopic dilution was employed to mitigate matrix effects. The procedure proposed in this study enables the simultaneous identification and assessment of residual levels of 214 veterinary drugs at limits of detection of 0.1–10.0 ng/g with a significantly shortened analysis time (40–50 min) and reduced cost.

100 Deals associated with Carbendazole

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB11380

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Onychomycosis	China	-	-
Tinea	China	-	-
Tinea Pedis	China	-	-

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