Carbendazole

In this study, an effective method for the simultaneous determination of 24 Benzimidazoles in meat and meat products based on a modified QuEChERS sample preparation technique coupled with ultra-performance liquid chromatog.-tandem mass spectrometry was established.Then, BZDs in meat and meat products were extracted by 0.1 % ammonium hydroxide in acetonitrile, followed by cleanup with 0.1 g C₁₈ and 0.3 g MgSO₄, ionized in electrospray pos. ionization source mode, and scanned for determination of the precursor ion and product ion by mass spectrometry in multiple reaction monitoring mode.The results showed that 24 BZDs had good linearity in the range of 0.2-100 μg/kg with correlation coefficients >0.999, and the limits of detection ranged from 0.001 to 0.244 μg/kg and the limits of quantification were between 0.002 and 0.738 μg/kg.The average recoveries of BZDs at three different spike levels of 2, 20, and 50 μg/kg were 74.6 % -113.9 %, with intra-day and inter-day relative standard deviations less than 9.86 % and 11.03 %, resp.This method has been successfully applied to the determination of BZDs in real samples, providing a powerful tool for the monitoring of BZDs residues in animal-derived foods.

A 15-channel pressure filtration purification method was presented for high throughput sample preparation of aquatic products. A cost-effective device was constructed and melamine sponge was selected as the cleanup sorbent. Upon interfacing with HPLC-MS/MS, the analytical procedure demonstrated its suitability for quantifying 160 pesticides and veterinary drug residues in aquatic products such as fish, shrimp, and crab. The method achieved sample recoveries ranging from 61.3 to 124.9 %. The detection limits were established between 0.5 and 1.0 μg/kg, while the quantitation limits were confirmed to be within the range of 1.0-2.0 μg/kg. The method was applied to quantify the pesticide and veterinary drug residues in mostly consumed aquatic products from five coastal provinces in China. The results showed significant differences between different aquatic products in the concentrations of pesticide and veterinary drug residues, implying the necessity of supervision for the accurate determination of pesticides and veterinary drugs.