Evaluation of the Necessity of Long-term Pharmacological Treatment With Antipsychotics for the Prevention of Relapse in Long-term Stabilized Schizophrenic Patients: a Randomized, Single-blind, Longitudinal Trial

The main objective of the trial is to evaluate, how long an antipsychotic relapse-prevention should be continued and to which time a patient with schizophrenia is protected enough, so that a withdrawal or reduction of the medication seems appropriate. Relapse is defined as primary outcome.

Start Date01 Feb 2015

Sponsor / Collaborator

Technische Universität München

100 Clinical Results associated with Perazine Dimalonate

100 Translational Medicine associated with Perazine Dimalonate

100 Patents (Medical) associated with Perazine Dimalonate

Literatures (Medical) associated with Perazine Dimalonate

30 Apr 2021·Psychiatria PolskaQ4 · MEDICINE

False-positive drug test results in patients taking psychotropic drugs. A literature review

Q4 · MEDICINE

Review

Author: Padała, Olga ; Masternak, Sebastian ; Karakuła-Juchnowicz, Hanna

01 Dec 2016·Arthritis Research & TherapyQ2 · MEDICINE

Screening for peptides targeted to IL-7Rα for molecular imaging of rheumatoid arthritis synovium

Q2 · MEDICINE

ArticleOA

Author: Sauvage, Sébastien ; Devalckeneer, Aude ; Burtea, Carmen ; Muller, Robert N ; Beckers, Marie-Claire ; Salmon, Isabelle ; Vander Elst, Luce ; Sanli, Tuba ; Laurent, Sophie ; Fanfone, Deborah ; Lauwerys, Bernard R ; Rorive, Sandrine

BACKGROUNDInterleukin-7 receptor alpha (IL-7Rα) represents a biomarker with potential applications in rheumatoid arthritis (RA) diagnosis and therapy. We have therefore searched by phage display potential IL-7Rα specific peptides with the primary goal being to develop in vivo molecular imaging tools.METHODSIL-7Rα-targeted peptides were searched within a disulfide-constrained combinatorial phage displayed library of random linear heptapeptides. The apparent dissociation constant (K_d) and half maximal inhibition constant (IC₅₀) were estimated for phage clones and synthesized peptides by ELISA. We used 5-Aza-2'-deoxycytidine (ADC)-stimulated Jurkat cells and human synovial tissue from patients with RA for in vitro characterization of peptides. For molecular imaging studies performed by magnetic resonance imaging (MRI), experimental arthritis was induced in DBA/1 male mice by immunization with an emulsion of complete Freund's adjuvant and type II collagen from chicken sternal cartilage.RESULTSAfter several steps of phage display and peptide screening, two IL-7Rα-specific heptapeptides (P258 and P725) were selected from the initial library, based on their affinity for the target (extracellular domain of IL-7Rα, which contains a fibronectin type III repeat-like sequence). P258 (a linear peptide obtained by removing the Cys-constraint) had the lowest affinity for fibronectin itself and was therefore proposed for molecular imaging. After grafting to ultra-small superparamagnetic particles of iron oxide (USPIO), P258 produced a strong negative contrast on MRI in mice with collagen-induced arthritis (CIA), even at 2 hours post injection. The co-localization of USPIO-P258 with IL-7Rα-expressing cells in the synovial tissue from CIA mice and its ability to discriminate the level of IL-7R expression and the disease severity confirmed its efficacy as an in vivo IL-7Rα imaging agent. Interestingly, the cyclic peptide (P725), which was less adequate for molecular imaging because of higher affinity for fibronectin, had a strong ability to compete with IL-7 for the IL-7Rα binding sites, making it a potential candidate for blocking applications. Accordingly, P725 prevented the signal transducer and activator of transcription 5 (STAT5) activation induced by IL-7 in ADC-stimulated Jurkat cells.CONCLUSIONSThe two peptides identified in this work demonstrate that IL-7Rα targeting in RA presents potential applications for in vivo molecular imaging and putative blocking purposes.

01 Jan 1980·Archiv der Pharmazie

Bestimmung der Bindung von Perazin und Perazinsulfoxid an Humanserumalbumin

Article

Author: Hassan Mohamed‐Ali ; Abdelwahab Kinawi ; Brigitte Lüth

100 Deals associated with Perazine Dimalonate

External Link

KEGG	Wiki	ATC	Drug Bank
D01860	-	N05AB10	DB12710

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Behavioural disorders	-	-	-

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis