Delving into the Latest Updates on Balofloxacin with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Balofloxacin hydrate (JAN), Baloxin, Neuquinoron

+ [3]

Target

Bacterial DNA gyrase x Bacterial top IV

Action

inhibitors

Mechanism

Bacterial DNA gyrase inhibitors(Bacterial DNA gyrase inhibitors), Bacterial top IV inhibitors(Bacterial topoisomerase IV inhibitors)

Therapeutic Areas

Infectious DiseasesUrogenital Diseases

Active Indication

Bacterial InfectionsUrinary Tract Infections

Inactive Indication-

Originator Organization

JW PHARMACEUTICAL Corp.

Active Organization

Kyoto Pharmaceutical University

JW PHARMACEUTICAL Corp.

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

South Korea (06 May 1993),

Bacterial Infections

Regulation-

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Structure/Sequence

Molecular FormulaC20H24FN3O4

InChIKeyMGQLHRYJBWGORO-UHFFFAOYSA-N

CAS Registry127294-70-6

To study the relative bioavailability of balofloxacin capsules produced by Yuekang Pharmaceutical Group Co., Ltd. and balofloxacin tablets produced by Choongwae Pharma, South Korea, after a single oral administration to healthy adult male volunteers in China, and to evaluate the bioequivalence of the test preparation with the reference preparation.

Start Date28 Jun 2013

Sponsor / Collaborator

Yuekang Pharmaceutical Group Co., Ltd.

[+1]

100 Clinical Results associated with Balofloxacin

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100 Translational Medicine associated with Balofloxacin

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100 Patents (Medical) associated with Balofloxacin

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309

Literatures (Medical) associated with Balofloxacin

01 Apr 2025·Talanta

Pioneering NMR-based dereplication for identifying novel quinolone additives in personal care products: A new frontier in public health protection

Article

Author: Lin, Xiaoyu ; Wu, Xianfu ; Yuan, Ruxin ; Du, Xiaonan ; Lu, Yong ; Yang, Huiying

Personal care products (PCPs) are often adulterated with antimicrobial agents, such as quinolones, which pose risks to consumer safety and challenge regulatory oversight. Current detection methods rely on standard reference substances and are limited in identifying novel quinolone isomers and structural derivatives. In this study, we present the first use of MixONat, an advanced dereplication tool, combined with ¹³C NMR spectroscopy to detect illegal quinolone additives in PCPs. Key advancements include the establishment of an in-house quinolone database, innovative sample pretreatment methods, and the integration of these elements to improve the detection of new illegal additives in PCPs. Standard addition experiments in both blank matrices and commercial cosmetics successfully identified new quinolones not included in the database, with effective differentiation of stereoisomers such as ofloxacin and levofloxacin. The proposed approach significantly improves detection efficiency and accuracy, bolstering PCP safety regulations and contributing to public health protection.

01 Mar 2025·Journal of Hazardous Materials

Hepatotoxicity, developmental toxicity, and neurotoxicity risks associated with co-exposure of zebrafish to fluoroquinolone antibiotics and tire microplastics: An in silico study

Article

Author: Liu, Yajing ; Ding, Xiaowen ; Xiao, Botian ; Li, Yu ; Li, Xixi ; Zhang, Zuning ; Wen, Jingya ; Qian, Feng ; Pu, Qikun

This study aimed to investigate the differences in the mechanisms of microscopic hepatotoxicity, developmental toxicity, and neurotoxicity in aquatic organisms co-exposed to styrene-butadiene rubber tire microplastics (SBR TMPs) and fluoroquinolone antibiotics (FQs). We found that hepatotoxicity in zebrafish induced by SBR TMPs and FQs was significantly higher than developmental toxicity and neurotoxicity. Furthermore, the main effects of the FQs primarily manifested as synergistic toxicity, whereas the low- and high-order interactions of the FQs mainly exhibited synergistic and antagonistic effects, respectively. Factorial analysis and the mixture toxicity index revealed that the synergistic effects of lomefloxacin × moxifloxacin and ciprofloxacin × lomefloxacin × enrofloxacin interactions significantly contributed to hepatotoxicity in zebrafish exposed to SBR TMP. SBR TMPs and antibiotics primarily induced hepatotoxicity, developmental toxicity, and neurotoxicity in zebrafish by affecting the activities of Cyp1a, Acox1, TRα, and mAChR. The observed toxicities were closely linked to the hydrophilic/hydrophobic groups, electronegativity, group mass, and structural complexity of the FQ molecules. This study provides new insights regarding the toxicological risks to aquatic organisms from co-exposure to SBR TMPs and FQs from a microscopic perspective. Future studies should include a broader range of antibiotics and tire microplastics and consider their long-term adverse effects on aquatic life.

01 Feb 2025·Talanta

Proportionally controlled dual-chiral covalent organic frameworks via thiol-ene click reaction for efficient enantioseparation

Article

Author: Liao, Yifang ; Mu, Qixuan ; Cao, Liqin ; Li, Ruijun ; Ji, Yibing ; Zhang, Jiale

Developing a universally applicable and commercially hopeful chiral material is a significant challenge for the separation and analysis field. In this study, innovative dual-chiral CCOFs ([SH-β-CD-NALC]_x-COFs) modified with 6-deoxy-6-mercapto-β-cyclodextrin (SH-β-CD) and N-acetyl-l-cysteine (NALC) are presented. These CCOFs were synthesized using a single, one-step bottom-up approach at room temperature, specifically designed for enantiomer recognition and separation. We investigated the effect of varying ratios of multiple chiral selectors in CCOFs on chiral recognition abilities through adsorption experiments for the first time. The precisely engineered [SH-β-CD-NALC]_1/6-COF, with excellent stability, crystallinity, abundant chiral sites, and a greater specific surface area, was well suited as a chiral stationary phase (CSP) in various racemates separation. The results showed satisfactory resolution, column efficiency, stability, and reproducibility. In addition, mechanism studies have revealed that the dual-chiral COF can offer triple selectivity and achieve the effect where 1 + 1 is greater than 2. This work emphasized the advantages of dual-chiral COF in achieving racemic drug separation, providing a new approach for the development of high-performance chiral separation platforms in the future.

100 Deals associated with Balofloxacin

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