AG-270

France’s Servier is closing out 2020 with a bang. The company bolstered its presence in oncology with the acquisition of the clinical and research-stage oncology business of Agios Pharmaceuticals in a deal worth up to $2 billion. News of the acquisition caused shares of Agios to soar more than 26% in premarket trading to $41.80. Servier said the acquisition is in-line with the company’s strategic goal to become a “recognized and innovative player” in oncology. Servier has allocated 50% of its overall R&D budget to this therapeutic area. Agios’ oncology pipeline includes its oral leukemia treatment Tibsovo, which was approved by the U.S. Food and Drug Administration for patients with relapsed or refractory acute myeloid leukemia (R/R AML) with a susceptible isocitrate dehydrogenase-1 (IDH1) mutation. Tibsovo is also under investigation in two Phase III combination trials in newly diagnosed AML, and as a potential treatment for previously treated IDH1-mutant cholangiocarcinoma and IDH1-mutant myelodysplastic syndrome (MDS). With the acquisition, Servier increases its toehold in the U.S. market, which it established in 2018 with the launch of its U.S. subsidiary. Other assets in the deal include vorasidenib, an investigational, brain-penetrant, dual inhibitor of mutant IDH1 and IDH2 being assessed in a Phase III trial in patients with IDH-mutant low-grade glioma, as well as AG-270, an investigational first-in-class methionine adenosyltransferase 2a (MAT2A) inhibitor and AG-636, a novel inhibitor of dihydroorotate dehydrogenase. Servier will also acquire Agios' co-commercialization responsibilities for Bristol Myers Squibb's Idhifa (enasidenib). That means Servier will be responsible for conducting certain clinical development activities within that development program. Two years ago, Servier acquired Shire’s oncology business for $2.4 billion, which includes Oncospar (pegaspargase), a treatment for acute lymphoblastic leukemia and ex-U.S. rights to Onivyde (irinotecan pegylated liposomal formulation) for pancreatic cancer. Olivier Laureau, president of Servier, said the strategic acquisition of Agios’ oncology business supports the company’s goal of bolstering its presence in the lucrative oncology market and also supports its commitment to bringing new and innovative treatments to patients. “It is a key step for the Servier Group as it will significantly strengthen our position in the U.S. and reinforce our R&D capabilities in oncology.” Former Shire executive David K. Lee, chief executive officer of Servier Pharmaceuticals, the French company’s U.S. subsidiary, noted that Agios plays an important role in the cellular metabolism space and has an established track record of developing precision drugs. “The acquisition of Agios' oncology business, including highly experienced talent from research, development, technical operations and commercial functions, allows for an immediate expansion of our U.S. business into other hematologic malignancies and provides the potential for longer-term growth into the solid tumor space, thus ensuring that we can serve more patients living with unmet cancer needs than ever before,” Lee said in a statement. Under terms of the deal, Servier paid Agios $1.8 billion upfront for the oncology business. The company could pay an additional $200 million in regulatory milestone payments, plus additional royalties. In addition to its acquisition of Agios’ oncology business, Servier and Celsius Therapeutics inked a deal focused on the identification and validation of novel colorectal cancer (CRC) drug targets. Celsius will use its proprietary single-cell genomics platform to analyze hundreds of samples from defined CRC patient populations and will validate new drug targets over a three-year period. Servier will then have an exclusive option to research, develop, and commercialize products directed to up to three of the targets. Under the terms of collaboration, Celsius will receive an upfront payment and research funding, and would be eligible to receive over $700 million in potential discovery, development, and commercialization milestone payments, along with tiered royalties. Most Read Today

Summary Agios Pharmaceuticals Inc Agios is a biopharmaceutical company that focuses on the discovery and development of investigational medicines for the treatment of cancer and rare genetic metabolic disorders. The company's products include IDHIFA, an oral targeted inhibitor of the mutated IDH2 enzyme used for the treatment of patients with R/R acute myeloid leukemia AML; and TIBSOVO ivosidenib, a prescription medicine used to treat adults with AML. Its pipeline products include AG881, a panIDH mutant inhibitor intended for the treatment of hematologic malignancies and solid tumors; AG270, an inhibitor of methionine adenosyltransferase 2a; and Mitapivat, a potent activator intended for the treatment of patients with pyruvate kinase deficiency. Agios is headquartered in Cambridge, Massachusetts, the US. Agios Pharmaceuticals Inc AGIO Pharmaceuticals Healthcare Deals and Alliances Profile provides you comprehensive data and trend analysis of the company's Mergers and Acquisitions MAs, partnerships and financings. The report provides detailed information on Mergers and Acquisitions, Equity/Debt Offerings, Private Equity, Venture Financing and Partnership transactions recorded by the company over a five year period. The report offers detailed comparative data on the number of deals and their value categorized into deal types, subsector and regions. GlobalData derived the data presented in this report from proprietary inhouse Pharma eTrack deals database, and primary and secondary research. Scope Financial Deals Analysis of the company's financial deals including Mergers and Acquisitions, Equity/Debt Offerings, Private Equity, Venture Financing and Partnerships. Deals by Year Chart and table displaying information encompassing the number of deals and value reported by the company by year, for a five year period. Deals by Type Chart and table depicting information including the number of deals and value reported by the company by type such as Mergers and Acquisitions, Equity/Debt Offering etc. Deals by Region Chart and table presenting information on the number of deals and value reported by the company by region, which includes North America, Europe, Asia Pacific, the Middle East and Africa and South and Central America. Deals by Subsector Chart and table showing information on the number of deals and value reported by the company, by subsector. Major Deals Information on the company's major financial deals. Each such deal has a brief summary, deal type, deal rationale; and deal financials and target Company's major public companies key financial metrics and ratios. Business Description A brief description of the company's operations. Key Employees A list of the key executives of the company. Important Locations and Subsidiaries A list and contact details of key centers of operation and subsidiaries of the company. Key Competitors A list of the key competitors of the company. Key Recent Developments A brief on recent news about the company. Reasons to Buy Get detailed information on the company's financial deals that enable you to understand the company's expansion/divestiture and fund requirements The profile enables you to analyze the company's financial deals by region, by year, by business segments and by type, for a five year period. Understand the company's business segments' expansion / divestiture strategy The profile presents deals from the company's core business segments' perspective to help you understand its corporate strategy. Access elaborate information on the company's recent financial deals that enable you to understand the key deals which have shaped the company Detailed information on major recent deals includes a summary of each deal, deal type, deal rationale, deal financials and Target Company's key financial metrics and ratios. Equip yourself with detailed information about the company's operations to identify potential customers and suppliers. The profile analyzes the company's business structure, locations and subsidiaries, key executives and key competitors. Stay uptodate on the major developments affecting the company Recent developments concerning the company presented in the profile help you track important events. Gain key insights into the company for academic or business research Key elements such as break up of deals into categories and information on detailed major deals are incorporated into the profile to assist your academic or business research needs. Note*: Some sections may be missing if data is unavailable for the company.