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Clinical Trials associated with SCRI-huCAR19v1(Seattle Children's Hospital)Pediatric and Young Adult Leukemia Adoptive Therapy (PLAT)-06: A Phase 1/2 Study of CD19-specific CAR T Cells With a Fully Human Binding Domain for CD19+ Leukemia or Lymphoma
Patients with relapsed or refractory leukemia or lymphoma are often refractory to further chemotherapy. In this study, the investigators will attempt to use T cells obtained directly from the patient, which can be genetically engineered to express a fully human chimeric antigen receptor (CAR). The CAR used in this study can recognize CD19, a protein expressed on the surface of leukemia and lymphoma cells. The fully human CAR used in this study may help protect against rejection of the CAR T cells, which in turn could lead to lasting protection against return of the leukemia or lymphoma. The phase 1 part of this study will determine the safety of these CAR T cells, and the phase 2 part of the study will determine how effective this CAR T cell therapy is. Both patients who have never had prior CAR T cell therapy and those who have had prior CAR T cell therapy may be eligible to participate in this study.
100 Clinical Results associated with SCRI-huCAR19v1(Seattle Children's Hospital)
100 Translational Medicine associated with SCRI-huCAR19v1(Seattle Children's Hospital)
100 Patents (Medical) associated with SCRI-huCAR19v1(Seattle Children's Hospital)
100 Deals associated with SCRI-huCAR19v1(Seattle Children's Hospital)