Author: Camero, Michele ; Catella, Cristiana ; Lanave, Gianvito ; Tempesta, Maria ; Buonavoglia, Alessio ; Lucente, Maria Stella ; Mari, Viviana ; Sposato, Alessio ; Martella, Vito

AbstractBackgroundCoronaviruses (CoVs) are major human and animal pathogens and antiviral drugs are pursued as a complementary strategy, chiefly if vaccines are not available. Feline infectious peritonitis (FIP) is a fatal systemic disease of felids caused by FIP virus (FIPV), a virulent pathotype of feline enteric coronavirus (FeCoV). Some antiviral drugs active on FIPV have been identified, but they are not available in veterinary medicine. ERDRP-0519 (ERDRP) is a non-nucleoside inhibitor, targeting viral RNA polymerase, effective against morbilliviruses in vitro and in vivo.ResultsThe antiviral efficacy of ERDRP against a type II FIPV was evaluated in vitro in Crandell Reese Feline Kidney (CRFK) cells. ERDRP significantly inhibited replication of FIPV in a dose-dependent manner. Viral infectivity was decreased by up to 3.00 logarithms in cell cultures whilst viral load, estimated by quantification of nucleic acids, was reduced by nearly 3.11 logaritms.ConclusionsThese findings confirm that ERDRP is highly effective against a CoV. Experiments will be necessary to assess whether ERDRP is suitable for treatment of FIPV in vivo.

Nature CommunicationsQ1 · CROSS-FIELD

Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding

Q1 · CROSS-FIELD

ArticleOA

Author: Santibanez, Sabine ; Cox, Robert M ; Pfeffermann, Kristin ; Sticher, Zachary M ; Kolkykhalov, Alexander A ; Anderson, Danielle E ; Wittwer, Kevin ; Plemper, Richard K ; Mankertz, Annette ; Plesker, Roland ; Wolf, Josef D ; Pfaller, Christian K ; von Messling, Veronika ; Natchus, Michael G

AbstractMeasles virus (MeV) is a highly contagious pathogen that enters the human host via the respiratory route. Besides acute pathologies including fever, cough and the characteristic measles rash, the infection of lymphocytes leads to substantial immunosuppression that can exacerbate the outcome of infections with additional pathogens. Despite the availability of effective vaccine prophylaxis, measles outbreaks continue to occur worldwide. We demonstrate that prophylactic and post-exposure therapeutic treatment with an orally bioavailable small-molecule polymerase inhibitor, ERDRP-0519, prevents measles disease in squirrel monkeys (Saimiri sciureus). Treatment initiation at the onset of clinical signs reduced virus shedding, which may support outbreak control. Results show that this clinical candidate has the potential to alleviate clinical measles and augment measles virus eradication.

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Indication	Highest Phase	Country/Location	Organization	Date
Measles	Preclinical	US	Georgia State University	-

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