Last update 16 May 2025

Hydroxychloroquine Sulfate/Sirolimus

Overview

Basic Info

Drug Type
Non-degrading molecular glue
Synonyms
JP-001
Target
mTOR x mTORC1 x mTORC2
Action
inhibitors
Mechanism
mTOR inhibitors(Serine/threonine-protein kinase mTOR inhibitors), mTORC1 inhibitors(Mammalian target of Rapamycin (mTORC1) inhibitors), mTORC2 inhibitors(mTOR Complex 2 inhibitors)
Therapeutic Areas
NeoplasmsNervous System DiseasesOther Diseases
Active Indication
NeoplasmsGlioblastoma MultiformeGlioblastoma
Inactive Indication-
Originator Organization
Johnpro Biotech, Inc.
Active Organization
Johnpro Biotech, Inc.Beijing Huibao Yuan Biotechnology Co., Ltd.Beijing Huibao Yuan Biotechnology Co., Ltd.
Inactive Organization-
License Organization
Beijing Huibao Yuan Biotechnology Co., Ltd.Beijing Huibao Yuan Biotechnology Co., Ltd.Johnpro Biotech, Inc.
Drug Highest PhasePhase 2/3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC18H28ClN3O5S
InChIKeyJCBIVZZPXRZKTI-UHFFFAOYSA-N
CAS Registry747-36-4
View All Structures (2)

Related

1
Clinical Trials associated with Hydroxychloroquine Sulfate/Sirolimus
NCT03008148
/ RecruitingPhase 2/3
Randomized Phase II/III Trial of Radiotherapy Plus Concomitant and Adjuvant Temozolomide With or Without Hydroxychloroquine, Rapamycin for Newly Diagnosed Glioblastoma
100 Clinical Results associated with Hydroxychloroquine Sulfate/Sirolimus
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100 Translational Medicine associated with Hydroxychloroquine Sulfate/Sirolimus
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100 Patents (Medical) associated with Hydroxychloroquine Sulfate/Sirolimus
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100 Deals associated with Hydroxychloroquine Sulfate/Sirolimus
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NeoplasmsPhase 3
China
Johnpro Biotech, Inc.
30 Jan 2022
Glioblastoma MultiformePhase 3
Taiwan Province
Johnpro Biotech, Inc.
11 Oct 2018
GlioblastomaIND Approval
China
Beijing Huibao Yuan Biotechnology Co., Ltd.Beijing Huibao Yuan Biotechnology Co., Ltd.
10 May 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Clinical Trial

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Approval

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Regulation

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