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Last update 08 May 2025

Glyfosfin

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target-

Action

inhibitors

Mechanism

DNA synthesis inhibitors

Therapeutic Areas

NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases+ [3]

Active Indication

Breast CancerLeukemiaLymphoma+ [2]

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC2H2O2

InChIKeyLEQAOMBKQFMDFZ-UHFFFAOYSA-N

CAS Registry107-22-2

100 Clinical Results associated with Glyfosfin

100 Translational Medicine associated with Glyfosfin

100 Patents (Medical) associated with Glyfosfin

10,285

Literatures (Medical) associated with Glyfosfin

31 Dec 2025·Energy Sources, Part A: Recovery, Utilization, and Environmental Effects

Non-catalytic desulfurization of model diesel using synthesized biodegradable ionic liquid

Author: Kundu, Subhajit ; Mitra, Debarati

The conventional processes generally used by petroleum refineries for eradication of sulfur compounds from diesel, namely, diesel hydrotreating is associated with the problem of high cost in terms of energy consumption, catalyst regeneration, etc.The present work has spotted a diesel desulfurization process at ambient temperature (25°C) without using any catalyst.Solvent extraction was applied to eliminate heterocyclic sulfur compounds from model diesel using a novel ionic liquid, which was synthesized from basic raw materials and characterized by common techniques like Fourier Transform IR (FTIR) spectroscopy and NMR (NMR) spectroscopy.A preliminary biodegradation study of the synthesized ionic liquid revealed 49.98% biodegradability after 35 days.The compounds present in the synthesized ionic liquid are 1,3-diethyl-1H-1,2,3-triazol-3-ium acetate ([Etim][OAc]), 1,3-diethyl-1H-imidazol-3-ium ([Eiim][OAc]), and 1-ethyl-3-methyl-3H-pyrazol-1-ium acetate ([EMpim][OAc]).The maximum desulfurization efficiency was 99.09% for dibenzothiophene (DBT) and 97.94% for thiophene using a solvent to feed ratio of 1:1 and applying a stirring time of 60 min.The quality of the model diesel has been checked with respect to flash point, aniline point, diesel index, and cetane index both pre- and post-desulfurization.

01 Sep 2025·Biomaterials

Biodegradable, electroconductive self-healing hydrogel based on polydopamine-coated polyurethane nano-crosslinker for Parkinson's disease therapy

Article

Author: Wen, Tsung-Kai ; Chen, Tsai-Yu ; Hsu, Shan-Hui ; Tai, Chun-Hwei ; Xu, Junpeng

Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons, causing motor and neurological impairments. Current treatments offer only temporary symptom relief without halting progression. Herein, a fully biodegradable, electroconductive self-healing hydrogel (CPUD gel) is developed, incorporating electroconductive polydopamine-coated polyurethane nanoparticles (PUD) as crosslinker. The core-shell PUD nanoparticles have a highly uniform size of ∼36 nm with a polydopamine shell of ∼4.8 nm thick on polyurethane core, revealed by small angle X-ray scattering, and own a conductivity of ∼0.82 mS/cm. As nano-crosslinker, the PUD can react with chitosan to form the dynamic CPUD hydrogel with shear modulus (∼280 Pa) and conductivity (∼4.34 mS/cm), mimicking brain tissue properties. In vitro, CPUD gel supports neural stem cell (NSC) proliferation (∼565 %) and differentiation, with elevated neuronal marker expression at 14 days, while exhibiting strong antioxidative and anti-inflammatory effects, rescuing ∼88 % inflamed NSCs. A therapeutic strategy combining injectable CPUD gel with acupuncture in a PD rat model, aiming to activate the innate regenerative mechanisms of body through mobilized endogenous stem cells, is further established. Using this approach, this hydrogel significantly elevates serum TGF-β1/SDF-1 levels, promotes dopaminergic neuron regeneration (>80 %), modulates neuroinflammation through M1-to M2-microglia transition (∼12.6-fold M2/M1 ratio), and improves motor function (from 8 % to 37 % forelimb contacts) in 14 days. Particularly, the electrophysiological spike rate is recovered from 66 to 19 spikes/s, close to the healthy rate 15 spikes/s. The synergistic immunomodulation and neuroprotection highlight the potential of CPUD gel as an advanced therapeutic tool for PD.

01 Jun 2025·Optics & Laser Technology

Measurements of the single-wavelength aerosol Ångström exponent based on differential absorption

Author: Cheng, Yuan ; Kong, Zheng ; Mei, Liang ; Yu, Jiheng

A novel method has been proposed and demonstrated for measuring the aerosol Ångstrom exponent at a specific wavelength based on differential absorption.The lidar system employs a high-power 450-nm diode laser as the light source, alternately emitting laser beams at two different wavelengths with an interval of about 1.4 nm.The aerosol extinction coefficient is retrieved according to the Fernald method from lidar measurements and the differential extinction coefficient is obtained through differential absorption measurements at the two wavelengths, from which the single-wavelength Ångstrom exponent can be obtained.Atm. aerosol measurements have been carried out for two weeks on the horizontal direction in Dalian city.The results indicate that there is a neg. correlation between the single-wavelength Ångstrom exponent and the relative humidity (RH), especially under high aerosol-load conditions, with a correlation coefficient up to 0.76.In addition, the single-wavelength Ångstrom exponent exhibits a strong neg. correlation with the aerosol concentration, with a correlation of -0.812 under high RH conditions.

100 Deals associated with Glyfosfin

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Breast Cancer	China	-	-
Leukemia	China	-	-
Lymphoma	China	-	-
Small Cell Lung Cancer	China	-	-
Uterine Cervical Cancer	China	-	-

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Glyfosfin

Overview

Basic Info

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Translational Medicine

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Clinical Trial

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