After signing the informed consent, the participant will be allocated to either intervention or control group, then each participant will use either 0.15% benzydamine (Comparator) or 4% tulsi (Intervention) four times a day and also once half an hour before each radiotherapy session.

Start Date01 Jul 2022

Sponsor / Collaborator

Cairo University

100 Clinical Results associated with Ocimum tenuiflorum Extract

100 Translational Medicine associated with Ocimum tenuiflorum Extract

100 Patents (Medical) associated with Ocimum tenuiflorum Extract

Literatures (Medical) associated with Ocimum tenuiflorum Extract

27 Aug 2024·Cureus

Evaluation of Antibacterial Effects of an Oral Rinse Containing Ocimum tenuiflorum and Ocimum gratissimum on Streptococcus mutans and Lactobacillus Species

Article

Author: Subramanian, Aravind Kumar ; Shanmugam, Rajeshkumar ; Loganathan, Akshetha ; Varghese, Remmiya Mary

BACKGROUND AND AIMDental caries, primarily caused by Streptococcus mutans and Lactobacillus spp., is a major global health issue. There is a growing need for effective, natural antimicrobial treatments. Ocimum tenuiflorum and Ocimum gratissimum are known for their medicinal properties, including antimicrobial activity. This study investigates the antibacterial efficacy of a herbal oral rinse derived from these plants. This study aimed to evaluate the antibacterial activity of an herbal formulation-based oral rinse prepared from Ocimum tenuiflorum and Ocimum gratissimum against Streptococcus mutans and Lactobacillus spp.METHODSFresh leaves of Ocimum tenuiflorum and Ocimum gratissimum were shade-dried, powdered, and extracted in distilled water. The extract was incorporated into an oral rinse formulation. The antibacterial activity was assessed using the agar well diffusion method, protein leakage and cytoplasmic leakage assays, and time-kill curve analysis. A commercial oral rinse was used as a standard.RESULTSThe herbal oral rinse exhibited significant antibacterial activity against both Streptococcus mutans and Lactobacillus spp. The zones of inhibition for Streptococcus mutans were 10 mm, 13 mm, and 15 mm at concentrations of 25 µg/mL, 50 µg/mL, and 100 µg/mL, respectively. For Lactobacillus spp., the inhibition zones were 10 mm, 12 mm, and 14 mm at the same concentrations. The protein leakage and cytoplasmic leakage analysis supported these findings, demonstrating the formulation's efficacy at low concentrations. Time-kill curve assays showed rapid bactericidal action, particularly at higher concentrations.CONCLUSIONThe Ocimum tenuiflorum and Ocimum gratissimum-based herbal oral rinse demonstrates strong antibacterial activity against key oral pathogens, suggesting that it could be a natural alternative to conventional oral rinses.

02 Jun 2024·Cureus

Comparative Anti-inflammatory Activity of a Nanocomposite-Based Herbal Oral Rinse and a Commercial Oral Rinse

Article

Author: Divakar, Anjusha ; Shanmugam, Rajeshkumar ; Varghese, Remmiya Mary ; S, Aravind Kumar

INTRODUCTIONThe present study aimed to evaluate and compare the anti-inflammatory effects of two oral rinse formulations, a commercial oral rinse and an Ocimum tenuiflorum and Ocimum gratissimum (nanocomposites, NCs) oral rinse, using in vitro assays commonly employed to assess anti-inflammatory activity.MATERIALS AND METHODSThe anti-inflammatory potential of the oral rinse formulations was assessed using bovine serum albumin (BSA) denaturation, egg albumin denaturation, and membrane stabilization assays. Diclofenac sodium was used as a reference standard in all assays. The inhibition percentages of BSA denaturation and egg albumin denaturation assays, as well as membrane stabilization effects, were measured at various concentrations of the oral rinse formulations.RESULTSBoth the commercial oral rinse and the Ocimum tenuiflorum and Ocimum gratissimum oral rinse demonstrated significant inhibition of BSA denaturation, indicating their anti-inflammatory potential. The Ocimum tenuiflorum and Ocimum gratissimum (NCs) oral rinse consistently showed higher inhibition percentages than the commercial oral rinse, suggesting stronger anti-inflammatory effects in this assay. In the egg albumin denaturation assay, both formulations exhibited inhibition of protein denaturation, with the Ocimum tenuiflorum and Ocimum gratissimum (NCs) oral rinse showing comparable or slightly higher inhibition percentages. The membrane stabilization assay further supported the anti-inflammatory properties of both formulations, with the Ocimum tenuiflorum and Ocimum gratissimum (NCs) oral rinse demonstrating efficacy comparable to diclofenac sodium.DISCUSSIONThe results suggest that Ocimum tenuiflorum and Ocimum gratissimum (NCs) oral rinse may possess stronger anti-inflammatory effects compared to commercial oral rinse, as evidenced by higher inhibition percentages in the BSA denaturation assay. Both formulations showed promising anti-inflammatory activity in the egg albumin denaturation and membrane stabilization assays, indicating their potential for mitigating inflammation.CONCLUSIONThe Ocimum tenuiflorum and Ocimum gratissimum (NCs) oral rinse exhibits significant anti-inflammatory effects in vitro, potentially surpassing the efficacy of the commercial oral rinse. Further studies are needed to explore the clinical implications of these findings and to validate the anti-inflammatory properties of the Ocimum tenuiflorum and Ocimum gratissimum (NCs) oral rinse in vivo.

01 Mar 2012·Canadian Journal of Physiology and PharmacologyQ4 · MEDICINE

Islet protective and insulin secretion property of Murraya koenigii and Ocimum tenuflorum in streptozotocin-induced diabetic mice

Q4 · MEDICINE

Article

Author: Joshi, Bimba N. ; Dusane, Menakshi Bhat

The present study investigates the antidiabetogenic effects of Murraya koenigii (L.) Spr. and Ocimum tenuflorum L. on streptozotocin-induced diabetic Swiss mice. Treatment with extracts of M. koenigii (chloroform; MKC) and O. tenuflorum (aqueous; OTA) resulted in proper glucose utilization with an increase in liver glucose-6-phosphate dehydrogenase enzyme activity, and normal glycogenesis in hepatic and muscle tissues. Pancreatic and intestinal glucosidase inhibitory activity observed with MKC and OTA treatment indicated beneficial effects in reducing postprandial hyperglycemia with concomitant improvement in glucose metabolism. The glucosidase inhibition was prolonged, even after discontinuation of MKC and OTA treatment. Normalization of plasma insulin and C-peptide levels was observed in diabetic mice, indicating endogenous insulin secretion after treatment. The histochemical and immunohistochemical analysis of pancreatic islets suggests the role of MKC and OTA in pancreatic β-cell protection and the functional pancreatic islets that produce insulin. The study demonstrates the significance of MKC and OTA in glucosidase inhibition and islet protection in the murine diabetic model. These findings suggest the potential of the extracts in adjuvant therapy for the treatment of diabetes and the possible development of potential neutraceuticals.

100 Deals associated with Ocimum tenuiflorum Extract

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Indication	Highest Phase	Country/Location	Organization	Date
Stomatitis	Phase 2	-	Cairo University	01 Jul 2022

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