Delving into the Latest Updates on Pegacaristim with Synapse

Overview

Basic Info

Drug Type

Colony-stimulating factors

Synonyms

MGDF, Megakaryocyte growth and development factor, PEG thrombopoietin

+ [10]

Target

TPO receptor

Mechanism

TPO receptor agonists(Thrombopoietin receptor agonists)

Therapeutic Areas

Hemic and Lymphatic DiseasesOther Diseases

Active Indication-

Inactive Indication

Chemotherapy-induced damageThrombocytopenia

Originator Organization

Kirin

Active Organization-

Inactive Organization

Amgen, Inc.

Kirin Holdings Co., Ltd.

ZymoGenetics, Inc.

Drug Highest PhaseDiscontinuedPhase 3

First Approval Date-

Regulation-

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Gene Sequence

Sequence Code 444637

Source: *****

BACKGROUNDWe previously showed that Lactobacillus brevis-derived polyphosphate (poly P) exerts a curative effect on intestinal inflammation. However, whether or not poly P improves the inflammation and injury of distant organs remains unclear.AIMSWe aimed to investigate the change in the intestinal microbiome and to evaluate the protective effect of poly P on injuries in a cerulein-induced acute pancreatitis (AP) mouse.METHODSPoly P was orally administered to BALB/C mice every day for 24 days, and then mice were intraperitoneally injected with cerulein. Before cerulein injection, stool samples were collected and analyzed by 16S rRNA gene sequencing. Mice were sacrificed at 24 h after the last cerulein injection; subsequently, the serum, pancreas, and colon were collected.RESULTSThe microbial profile differed markedly between poly P and control group. Notably, the levels of beneficial bacteria, including Alistipes and Candidatus_Saccharimonas, were significantly increased, while those of the virulent bacteria Desulfovibrio were decreased in the poly P group. The elevations of the serum amylase and lipase levels by cerulein treatment were suppressed by the pre-administration of poly P for 24 days, but not for 7 days. The numbers of cells MPO-positive by immunohistology were decreased and the levels of MCP-1 significantly reduced in the AP + Poly P group. An immunofluorescence analysis showed that the ZO-1 and occludin in the colon was strongly augmented in the epithelial cell membrane layer in the AP + Poly P group.CONCLUSIONSPoly P attenuates AP through both modification of the intestinal microbiome and enhancement of the intestinal barrier integrity.

29 Mar 2021·Mediators of InflammationQ3 · MEDICINE

Probiotic-Derived Polyphosphate Accelerates Intestinal Epithelia Wound Healing through Inducing Platelet-Derived Mediators

Q3 · MEDICINE

ArticleOA

Author: Tanaka, Hiroki ; Ueno, Nobuhiro ; Kashima, Shin ; Ando, Katsuyoshi ; Konishi, Hiroaki ; Fujiya, Mikihiro ; Moriichi, Kentaro ; Isozaki, Shotaro ; Okumura, Toshikatsu ; Murakami, Yuki

Inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD), is an intractable intestinal inflammation associated with the disruption of the intestinal mucosa. We previously demonstrated that Lactobacillus brevis-derived long-chain polyphosphate (poly P) improved the intestinal barrier function by the upregulation of cell adhesion and relieved intestinal inflammation, thereby exerting a curing effect on colitis in vitro, in vivo, and in an investigator-initiated clinical study of UC. However, how poly P improves mucosal defects induced by intestinal inflammation has not been elucidated. In this study, we detected the accumulation of platelets in inflamed tissues induced by poly P in a dextran sulfate sodium- (DSS-) induced colitis mouse model. A light transmission aggregometry analysis and scanning electron microscopy showed that poly P promoted the platelet aggregation. An SRB assay and ki-67 staining showed that the supernatant of poly P-treated platelet-rich plasma (PRP) increased intestinal epithelial cell growth. A wound healing assay showed that the supernatant of poly P-treated PRP, but not poly P itself, accelerated wound healing. A Western blotting analysis indicated that mitogen-activated protein kinase activation was induced by the supernatant of poly P-treated human PRP in the epithelial cells and its wound healing effect was significantly decreased by the inhibition of ERK signaling. These data suggested that platelet-derived mediators induced by poly P improved intestinal inflammation through the promotion of epithelial cell growth by the activation of the ERK signaling pathway. The mechanism is a novel host-microbe interaction through mammalian platelet-derived mediators induced by bacterial molecules.

01 Nov 2020·The Journal of clinical and aesthetic dermatology

An Assessment of Microneedling with Topical Growth Factors for Facial Skin Rejuvenation: A Randomized Controlled Trial.

Article

Author: Merati, Miesha ; Reznik, Nina ; Woods, Christi ; Parker, Lydia

BACKGROUND: The study of the use of growth factors in conjunction with microneedling is limited. It is hypothesized that the use of human growth factors will decrease recovery time by downregulating inflammation and will continue stimulating collagen synthesis initiated by microneedling. OBJECTIVE: We sought to evaluate the safety and efficacy of microneedling in combination with a novel human recombinant growth factor regenerative complex (PolyGF) for skin improvement. METHODS: This study was a randomized controlled trial evaluating changes in multiple skin parameters via provider, imaging, and patient self-assessments after four microneedling treatments, each spaced one month apart, with or without a novel growth factor. Twenty female patients aged 35 to 60 years were included. Evaluation parameters included fine lines and wrinkles, evenness of skin tone, skin clarity, age spots, skin smoothness, skin firmness, and hydration of skin via dermatologic Canfield VISIA (Fairfield, New Jersey) imaging, and patient self-assessment. RESULTS: Significant improvement in skin texture was reported to higher degrees for the PolyGF group by VISIA imaging assessments than in the control group. Subjective assessments in skin smoothness and hydration were significantly improved in the Poly GF groups. Hydration improvements were seen to a lesser degree in the control group. Improvements in firmness and texture were seen in both the PolyGF and control groups by subjective assessment. Significantly improved subjective assessments of skin tone and melanin index were reported only in the control groups. CONCLUSION: While microneedling improved skin in several parameters, the addition of the novel growth factor to microneedling helped improve skin texture and hydration to a higher degree. Further studies are needed to characterize the effects of growth factor serum in conjunction with microneedling.

100 Deals associated with Pegacaristim

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External Link

KEGG	Wiki	ATC	Drug Bank
D05383	-	-	-

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Chemotherapy-induced damage	Phase 3	US	ZymoGenetics, Inc.	-
Chemotherapy-induced damage	Phase 3	US	Amgen, Inc.	-
Thrombocytopenia	Phase 3	US	Amgen, Inc.	-
Thrombocytopenia	Phase 3	US	ZymoGenetics, Inc.	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ASGCT2024	Not Applicable	T Cell Immunodeficiency Primary	-	Ligand-Conjugated Poly (Beta-Amino Ester) Nanoparticles (Poly(beta-amino ester) nanoparticles with aCD3 and aCD28 targeting ligands)	uqjrghzakk(xailaoaucx) = particles with multiple targeting ligands (aCD3 and aCD28) achieved significantly higher T cell transfection than particles with only one or no targeting ligands nzwokhrdnr (axzhcfllkj ) View more	-	07 May 2024
				Ligand-Conjugated Poly (Beta-Amino Ester) Nanoparticles (Poly(beta-amino ester) nanoparticles with aCD3 targeting ligand)
ARVO2023	Not Applicable	-	-	Methacrylated poly-epsilon-lysine hydrogels	(cqcozulais) = xetyafznvg qxussqupod (mqllkdkujq ) View more	-	23 Apr 2023
Pubmed	Not Applicable	Hernia	121	Poly-4-hydroxybutyrate Mesh (Phasix Mesh)	(hqnbgoyzcz) = dixxjqvefl flzzljbucx (efrflrpano, 11.7 - 29.4) View more	-	17 Aug 2022
ARVO2018	Not Applicable	Eye Injuries, Penetrating	-	functionalized poly (N-isopropylacrylamide) (PNIPAM) polymers	(hpmjatwopb) = polymer uptake was observed at room temperature suggesting temperature dependent binding and uptake mechanism sntkuunreb (bnqawmrolh )	-	01 Jul 2018
				functionalized poly (N-isopropylacrylamide) (PNIPAM) polymers
APAO2018	Not Applicable	stress oxidative	-	Curcumin Poly(lactide-co-glycolide) Nanoparticles (CUR-NP)	rvtiedkloa(nvyewhexqx) = The protective effect of CUR-NP on oxidatively stressed hTM cells may be related to mitochondrial reactive oxygen species scavenge, suppressed inflammatory gene expression, including IL-1α, IL-6, and IL-8, and reduced caspase 3 activation rtdhbvyszh (adahnxilip ) View more	-	08 Feb 2018
ASGCT2017	Not Applicable	Hepatocellular Carcinoma	-	PBAE-NP formulation	otyqvycpkg(juvvnpopep) = jygysbksnc qnruszzmir (kixrridvzb ) View more	-	01 May 2017
				Poly(Beta-Amino Ester)	kqkqnlezsh(tkmiweieyt) = uaoalibcfb swtotjiinz (sckpviprhg ) View more
ARVO2014	Not Applicable	hCSSCs	-	Poly(lactide-co-glycolide) (PLGA)	rxhiquvyrd(qzuixuanuo) = collagenous ECM deposited by hCSSCs on the PLGA (50/50) substrate was much more abundant than that on PLGA (100/0) uibniwtbwz (ggqfmmqlcd ) View more	-	01 Apr 2014
				Poly(lactide-co-glycolide) (PLGA)
ARVO2012	Not Applicable	-	-	hRPE cells cultured with Rho kinase inhibitor	ktfnmbccwi(bwurcsnehb) = jwvxfzpofj mqtrlumhtl (mswsbvhmue ) View more	-	01 Mar 2012
				Poly-L-Lysine-coated plates without Rho kinase inhibitor	ktfnmbccwi(bwurcsnehb) = zmynqekndv mqtrlumhtl (mswsbvhmue ) View more
ARVO2010	Not Applicable	-	-	EOBO alone	eyjrhtnqhp(pqgzdofufl) = rlicdbevnk jkfolloiuc (koocpayxpz ) View more	-	01 Apr 2010
				Di-Block Copolymer, Poly(oxyethylene)-Poly(oxybutylene)	eyjrhtnqhp(pqgzdofufl) = cfzunqpjrr jkfolloiuc (koocpayxpz ) View more
ARVO2008	Not Applicable	-	-	Poly(vinylpyrrolidone) hydrogel	uyogcvtxvr(kfjvokmhhc) = qvkngdgqic eapnknvavq (evgydkpdcb ) View more	-	01 May 2008