Delving into the Latest Updates on Pegacaristim with Synapse

Overview

Basic Info

Drug Type

Colony-stimulating factors

Synonyms

Megakaryocyte growth and development factor, MGDF, PEG thrombopoietin

+ [10]

Target

TPO receptor

Mechanism

TPO receptor agonists(Thrombopoietin receptor agonists)

Therapeutic Areas

Hemic and Lymphatic DiseasesOther Diseases

Active Indication-

Inactive Indication

Chemotherapy-induced damageThrombocytopenia

Originator Organization

Kirin

Active Organization-

Inactive Organization

Amgen, Inc.

Kirin Holdings Co., Ltd.

ZymoGenetics, Inc.

Drug Highest PhaseDiscontinuedPhase 3

First Approval Date-

Regulation-

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Structure/Sequence

Sequence Code 444637

Source: *****

The role of food additives is to preserve food by extending shelf life and limiting harmful microorganism proliferation. They prevent spoilage by enhancing the taste and safety of food by utilizing beneficial microorganisms and their antimicrobial metabolites. Current advances in food preservation and processing utilize green technology principles for green preservative formulation, enhancing nutrition and supplying essential micronutrients safely, while also improving quality, packaging, and food safety. Encapsulation is gaining attention for its potential to protect delicate materials from oxidative degradation and extend their shelf life, thereby ensuring optimal nutrient uptake. Nanoencapsulation of bioactive compounds has significantly improved the food, pharmaceutical, agriculture, and nutraceutical industries by protecting antioxidants, vitamins, minerals, and essential fatty acids by controlling release and ensuring delivery to specific sites in the human body. This emerging area is crucial for future industrial production, improving the sensory properties of foods like color, taste, and texture. Research on encapsulated bioactive compounds like bacteriocins, LAB, natamycin, polylysine, and bacteriophage is crucial for their potential antioxidant and antimicrobial activities in food applications and the food industry. This paper reviews nanomaterials used as food antimicrobial carriers, including nanoemulsions, nanoliposomes, nanoparticles, and nanofibers, to protect natural food antimicrobials from degradation and improve antimicrobial activity. This review discusses nanoencapsulation techniques for biopreservative agents like nisin, poly lysine, and natamycin, focusing on biologically-derived polymeric nanofibers, nanocarriers, nanoliposomes, and polymer-stabilized metallic nanoparticles. Nanomaterials, in general, improve the dispersibility, stability, and availability of bioactive substances, and this study discusses the controlled release of nanoencapsulated biopreservative agents.

01 Nov 2021·Digestive diseases and sciencesQ3 · MEDICINE

Polyphosphate, Derived from Lactobacillus brevis, Modulates the Intestinal Microbiome and Attenuates Acute Pancreatitis

Q3 · MEDICINE

Article

Author: Kashima, Shin ; Isozaki, Shotaro ; Ueno, Nobuhiro ; Takauji, Shuhei ; Konishi, Hiroaki ; Moriichi, Kentaro ; Mizukami, Yusuke ; Sato, Hiroki ; Okumura, Toshikatsu ; Fujiya, Mikihiro ; Tanaka, Hiroki

BACKGROUND:

We previously showed that Lactobacillus brevis-derived polyphosphate (poly P) exerts a curative effect on intestinal inflammation. However, whether or not poly P improves the inflammation and injury of distant organs remains unclear.

AIMS:

We aimed to investigate the change in the intestinal microbiome and to evaluate the protective effect of poly P on injuries in a cerulein-induced acute pancreatitis (AP) mouse.

METHODS:

Poly P was orally administered to BALB/C mice every day for 24 days, and then mice were intraperitoneally injected with cerulein. Before cerulein injection, stool samples were collected and analyzed by 16S rRNA gene sequencing. Mice were sacrificed at 24 h after the last cerulein injection; subsequently, the serum, pancreas, and colon were collected.

RESULTS:

The microbial profile differed markedly between poly P and control group. Notably, the levels of beneficial bacteria, including Alistipes and Candidatus_Saccharimonas, were significantly increased, while those of the virulent bacteria Desulfovibrio were decreased in the poly P group. The elevations of the serum amylase and lipase levels by cerulein treatment were suppressed by the pre-administration of poly P for 24 days, but not for 7 days. The numbers of cells MPO-positive by immunohistology were decreased and the levels of MCP-1 significantly reduced in the AP + Poly P group. An immunofluorescence analysis showed that the ZO-1 and occludin in the colon was strongly augmented in the epithelial cell membrane layer in the AP + Poly P group.

CONCLUSIONS:

Poly P attenuates AP through both modification of the intestinal microbiome and enhancement of the intestinal barrier integrity.

29 Mar 2021·Mediators of inflammationQ3 · MEDICINE

Probiotic-Derived Polyphosphate Accelerates Intestinal Epithelia Wound Healing through Inducing Platelet-Derived Mediators

Q3 · MEDICINE

ArticleOA

Author: Konishi, Hiroaki ; Moriichi, Kentaro ; Ando, Katsuyoshi ; Murakami, Yuki ; Isozaki, Shotaro ; Okumura, Toshikatsu ; Fujiya, Mikihiro ; Ueno, Nobuhiro ; Tanaka, Hiroki ; Kashima, Shin

Inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD), is an intractable intestinal inflammation associated with the disruption of the intestinal mucosa. We previously demonstrated that Lactobacillus brevis-derived long-chain polyphosphate (poly P) improved the intestinal barrier function by the upregulation of cell adhesion and relieved intestinal inflammation, thereby exerting a curing effect on colitis in vitro, in vivo, and in an investigator-initiated clinical study of UC. However, how poly P improves mucosal defects induced by intestinal inflammation has not been elucidated. In this study, we detected the accumulation of platelets in inflamed tissues induced by poly P in a dextran sulfate sodium- (DSS-) induced colitis mouse model. A light transmission aggregometry analysis and scanning electron microscopy showed that poly P promoted the platelet aggregation. An SRB assay and ki-67 staining showed that the supernatant of poly P-treated platelet-rich plasma (PRP) increased intestinal epithelial cell growth. A wound healing assay showed that the supernatant of poly P-treated PRP, but not poly P itself, accelerated wound healing. A Western blotting analysis indicated that mitogen-activated protein kinase activation was induced by the supernatant of poly P-treated human PRP in the epithelial cells and its wound healing effect was significantly decreased by the inhibition of ERK signaling. These data suggested that platelet-derived mediators induced by poly P improved intestinal inflammation through the promotion of epithelial cell growth by the activation of the ERK signaling pathway. The mechanism is a novel host-microbe interaction through mammalian platelet-derived mediators induced by bacterial molecules.

100 Deals associated with Pegacaristim

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External Link

KEGG	Wiki	ATC	Drug Bank
D05383	-	-	-

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Chemotherapy-induced damage	Phase 3	US	ZymoGenetics, Inc.	-
Chemotherapy-induced damage	Phase 3	US	Amgen, Inc.	-
Thrombocytopenia	Phase 3	US	ZymoGenetics, Inc.	-
Thrombocytopenia	Phase 3	US	Amgen, Inc.	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ASGCT2024	Not Applicable	T Cell Immunodeficiency Primary	-	Ligand-Conjugated Poly (Beta-Amino Ester) Nanoparticles (Poly(beta-amino ester) nanoparticles with aCD3 and aCD28 targeting ligands)	wtyrmjexfr(hkaffzxkwd) = particles with multiple targeting ligands (aCD3 and aCD28) achieved significantly higher T cell transfection than particles with only one or no targeting ligands qednmgorvv (jkpzaekhvr ) View more	-	07 May 2024
				Ligand-Conjugated Poly (Beta-Amino Ester) Nanoparticles (Poly(beta-amino ester) nanoparticles with aCD3 targeting ligand)
ARVO2023	Not Applicable	-	-	Methacrylated poly-epsilon-lysine hydrogels	rnmlbkklgz(bcyqlfaglf) = aasackovvk ilhyylnstg (qyjfttltlj ) View more	-	23 Apr 2023
EASL2022	Not Applicable	-	-	Engineered NO donor PBAE NPs	mgkqbdfyyg(obyufkfnka) = hfzvbcxtix hlmrynloml (afiextbfda ) View more	Positive	26 Jun 2022
				Control NPs	mgkqbdfyyg(obyufkfnka) = guwueywjmy hlmrynloml (afiextbfda ) View more
ARVO2018	Not Applicable	Eye Injuries, Penetrating	-	functionalized poly (N-isopropylacrylamide) (PNIPAM) polymers (X13002-601 15:1)	lirzocurui(ugpxdiyiin) = polymer uptake was observed at room temperature suggesting temperature dependent binding and uptake mechanism jujjeslfgk (knxodxkigr )	-	01 Jul 2018
				functionalized poly (N-isopropylacrylamide) (PNIPAM) polymers (X13002-401 25:1)
APAO2018	Not Applicable	stress oxidative	-	Curcumin Poly(lactide-co-glycolide) Nanoparticles (CUR-NP)	gddrxlxprf(cjhtoadmzp) = The protective effect of CUR-NP on oxidatively stressed hTM cells may be related to mitochondrial reactive oxygen species scavenge, suppressed inflammatory gene expression, including IL-1α, IL-6, and IL-8, and reduced caspase 3 activation glcwrzjcvr (bxobchiplc ) View more	-	08 Feb 2018
ARVO2017	Not Applicable	Fungal keratitis	-	Amphotericin B (AmpB) pεK gel with neutralisation (-NH2)	uaklicozaf(imofabnczs) = above therapeutic levels (0.188 μg cm -3) hdbfksncmx (vfodbmcqmx ) View more	Positive	07 May 2017
				Amphotericin B (AmpB) pεK gel without neutralisation (-NH3Cl)
ASGCT2017	Not Applicable	Hepatocellular Carcinoma	-	PBAE-NP formulation	gxrjcrrezt(bnyoyauhte) = nzibqfkgbm pzihvnmbnm (akyukbtnue ) View more	-	01 May 2017
				Poly(Beta-Amino Ester) (Hepatocyte line)	hkfpmphjvl(jkauvwmark) = vsijxmrrhm sdcauviweb (dspbayqgql ) View more
ARVO2014	Not Applicable	hCSSCs	-	Poly(lactide-co-glycolide) (PLGA) (PLGA (100/0) scaffold)	uglawsmpsz(byjzkilsii) = collagenous ECM deposited by hCSSCs on the PLGA (50/50) substrate was much more abundant than that on PLGA (100/0) zekvrshkqq (pvoxbknocu ) View more	-	01 Apr 2014
				Poly(lactide-co-glycolide) (PLGA) (PLGA (50/50) scaffold)
ASCO2013	Not Applicable	Breast Cancer	-	BP-C1	oylfoldefd(kszeomrprl) = lsjnychkxc vwzhycawoz (empewoxuar )	-	20 May 2013
ARVO2010	Not Applicable	-	-	EOBO alone	esvkkwmuzf(iuyuydwtie) = zcsvmhzcue xsozkxcmyj (msoemmperv ) View more	-	01 Apr 2010
				Di-Block Copolymer, Poly(oxyethylene)-Poly(oxybutylene)lysozymelymer, Poly(oxyethylene)-Poly(oxybutylene) (EOBO-lysozyme mixture)	esvkkwmuzf(iuyuydwtie) = mehxxguiwl xsozkxcmyj (msoemmperv ) View more