Organochlorine pesticides in vegetable oils: An overview of occurrence, toxicity, and chromatographic determination in the past twenty-two years (2000–2022)

Review

Author: Mketo, Nomvano ; Munjanja, Basil K ; Nomngongo, Philiswa N

Organochlorine pesticides (OCPs) are used globally to control pests in the food industry. However, some have been banned due to their toxicity. Although they have been banned, OCPs are still discharged into the environment and persist for long periods of time. Therefore, this review focused on the occurrence, toxicity, and chromatographic determination of OCPs in vegetable oils over the last 22 years (2000-2022) (111 references). Literature search shows that OCPs kill pests by destroying endocrine, teratogenic, neuroendocrine, immune, and reproductive systems. However, only five studies investigated the fate of OCPs in vegetable oils and the outcome revealed that some of the steps involved during oil processing introduce more OCPs. Moreover, direct chromatographic determination of OCPs was mostly performed using online LC-GC methods fitted with oven transfer adsorption desorption interface. While indirect chromatographic determination was favored by QuEChERS extraction technique, gas chromatography frequently coupled to electron capture detection (ECD), gas chromatography in selective ion monitoring mode (SIM), and gas chromatography tandem mass spectrometry (GC-MS/MS) were the most common techniques used for detection. However, the greatest challenge still faced by analytical chemists is to obtain clean extracts with acceptable extraction recoveries (70-120%). Hence, more research is still required to develop greener and selective extraction methods toward OCPs, thus improving extraction recoveries. Moreover, advanced techniques like gas chromatography high resolution mass spectrometry (GC-HRMS) must also be explored. OCPs prevalence in vegetable oils varied greatly in various countries, and concentrations of up to 1500 µg/kg were reported. Additionally, the percentage of positive samples ranged from 1.1 to 97.5% for endosulfan sulfate.

01 Oct 2024·Respirology Case Reports

Successful treatment of large hemoptysis and pseudoaneurysm of the pulmonary artery associated to oesophagomediastinal fistula with amphotericin B cholesterol sulfate complex: A case report

Article

Author: Pi, Qiangzhong ; He, Jian ; Chen, Zhujun ; Gong, Liang ; Liang, Peiqiang ; Huang, Qin

AbstractOesophagomediastinal fistula is uncommon. Oesophageal fistulas, may manifest as recurrent pneumonias. While pulmonary infections can lead to pulmonary artery pseudoaneurysms (PAPs), particularly in fungal infections. PAPs pose a rupture risk, potentially causing life‐threatening hemoptysis. We report a unique case of a 45‐year‐old male who presented with sudden cough, dyspnea, and hemoptysis. Bronchoscopy triggered massive hemoptysis, necessitating emergency embolization. Persistent hemoptysis prompted further imaging, revealing an aneurysmal dilation located next to the spine and infectious lesions, suggesting an oesophagomediastinal fistula. After initiating therapy with Amphotericin B Cholesterol Sulfate Complex and fistula closure, the patient's hemoptysis resolved, with imaging resolution of the PAP. Long‐term Voriconazole therapy ensured continued improvement. This case highlights the rarity and severity of such fistulas may be associated with fungal infections and PAPs, emphasizing the importance of prompt recognition, aggressive treatment for favourable outcomes.

01 Jul 2024·Heliyon

Techniques for quantification of organochlorine pesticides from a validated method by using gas chromatography-electron capture detector

Article

Author: Chowdhury, Nushrat Jahan ; Ali Shaikh, Md. Aftab ; Nahar, Aynun ; Akbor, Md. Ahedul

Organochlorine pesticides (OCPs) are persistent organic compounds found in aquatic environments worldwide. A well-validated and well-established analytical method is crucial for detecting OCPs in the environment. In this study, an analytical method for quantifying OCPs in water was developed and evaluated. Here, the range of linearity, reproducibility, uncertainty, specificity, method detection limits (MDL), and special emphasis on detection and quantitation limits were assessed. Recovery studies were performed to measure the accuracy and precision of the method. This method exhibited excellent linearity in the range of 2.5-20 μg/L for all compounds. As none of the targeted compounds was detected in the chromatograms of the blank sample with no baseline noise, the limits of detection (LOD) and limits of quantification (LOQ) were determined using the linear regression method, external calibration curve slope, and laboratory fortified blank-based detection. All compounds showed different LOD and LOQ values, depending on the approach used. In particular, endosulfan sulfate, methoxychlor, endrin ketone, H. epoxide, heptachlor, and 4,4'-DDT exhibited high detection limits. The recovery percentage of the 15 compounds at 5 μg/L spiked concentration was between 50 and 150 %, which is consistent with the accuracy of the APHA method. Except for endosulfan sulfate, the relative standard deviations of all other compounds were below 20 %, indicating good precision. This method has also been applied to real water samples. This validation technique is reliable, sensitive, simple, rapid, easy to comprehend, and reproducible. The application of this method in the real water samples was also conducted. Only α-BHC and γ-Chlordane were detected in the water sample.

100 Deals associated with Dermatan sulfate

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	B01AX04	DB15880

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Thrombocytopenia	IT	Mediolanum Farmaceutici SpA	01 Jul 1998
Thrombosis	IT	Mediolanum Farmaceutici SpA	01 Jul 1998
Venous Thromboembolism	IT	Mediolanum Farmaceutici SpA	01 Jul 1998

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis


No Data

Dermatan sulfate

Overview

Basic Info

Related

External Link

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation