Delving into the Latest Updates on Mebeverine Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Mebeverine, Mebeverine hydrochloride (USAN)

+ [5]

Target

mAChRs

Mechanism

mAChRs antagonists(Muscarinic acetylcholine receptor antagonists)

Therapeutic Areas

Digestive System Disorders

Active Indication

GastrospasmIrritable Bowel Syndrome

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure

Molecular FormulaC25H36ClNO5

InChIKeyPLGQWYOULXPJRE-UHFFFAOYSA-N

CAS Registry2753-45-9

View All Structures (2)

The goal of this clinical trial is to compare the efficacy of four different drugs in combination for management of irritable bowel syndrome (IBS)-associated diarrhea. The main question to answer is:
Is there a significant difference in effect of different drug combinations in management of irritable bowel syndrome with diarrhea?
Participants will be divided into 3 treatment groups.
Each group will be given a combination of drugs for 2 weeks
At the end of study, efficacy of different drug combinations and their potential side effects will be compared between the treatment groups

Start Date03 Jan 2023

Sponsor / Collaborator

Bahria University

100 Clinical Results associated with Mebeverine Hydrochloride

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100 Translational Medicine associated with Mebeverine Hydrochloride

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100 Patents (Medical) associated with Mebeverine Hydrochloride

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206

Literatures (Medical) associated with Mebeverine Hydrochloride

01 Feb 2024·Biotechnology Journal

3D‐QSAR pharmacophore modeling, virtual screening, molecular docking, MD simulations, in vitro and in vivo studies to identify potential anti‐hyperplasia drugs

Article

Author: Khan, Dildar ; Akbar, Muhammad Yasir ; Chen, Jian-Zhong ; Wang, Hao ; Haq, Ihsan-Ul ; Khan, Muhammad Zafar Irshad

AbstractPsoriasis is a common immune‐mediated skin condition characterized by aberrant keratinocytes and cell proliferation. The purpose of this study was to explore the FDA‐approved drugs by 3D‐QSAR pharmacophore model and evaluate their efficiency by in‐silico, in vitro, and in vivo psoriasis animal model. A 3D‐QSAR pharmacophore model was developed by utilizing HypoGen algorithm using the structural features of 48 diaryl derivatives with diverse molecular patterns. The model was validated by a test set of 27 compounds, by cost analysis method, and Fischer's randomization test. The correlation coefficient of the best model (Hypo2) was 0.9601 for the training set while it was 0.805 for the test set. The selected model was taken as a 3D query for the virtual screening of over 3000 FDA‐approved drugs. Compounds mapped with the pharmacophore model were further screened through molecular docking. The hits that showed the best docking results were screened through in silico skin toxicity approach. Top five hits were selected for the MD simulation studies. Based on MD simulations results, the best two hit molecules, that is, ebastine (Ebs) and mebeverine (Mbv) were selected for in vitro and in vivo antioxidant studies performed in mice. TNF‐α and COX pro‐inflammatory mediators, biochemical assays, histopathological analyses, and immunohistochemistry observations confirmed the anti‐inflammatory response of the selected drugs. Based on these findings, it appeared that Ebs can effectively treat psoriasis‐like skin lesions and down‐regulate inflammatory responses which was consistent with docking predictions and could potentially be employed for further research on inflammation‐related skin illnesses such as psoriasis.

01 Jan 2024·Sudebno-meditsinskaya ekspertiza

Development of selective method for mebeverine detection in blood

Article

Author: Vikman, P S ; Strelova, O Yu ; Grebenyuk, A N ; Balabanova, O L

OBJECTIVETo develop the method of biological fluids' sample processing and mebeverine detection to exclude false results' receiving when diagnosing drug intoxication.MATERIAL AND METHODSThe study was carried out using «Mebeverine» (NJCO «North star», Russia) medicine and hydrolysis by enzymes, namely papain, chymotrypsin, trypsin, chymopsin and hyaluronidase, was applied for sample processing. The extractions were analyzed by methods of HPLC-MS/MS on Nexera XR modular liquid chromatograph with LCMS-8050 (Shimadzu) tandem mass spectrometer and GC-MS on gas chromatograph connected with QP-2020 (Shimadzu, Japanese) mono quadrupole mass spectrometer.RESULTS AND CONCLUSIONIt has been revealed that using selective method of sample processing, which consists of aqueous phase extraction at pH=2-4 and enzymatic hydrolysis by papain and hyaluronidase during isolation from blood, is required to detect mebeverine in biological liquids. It has been proven that the native mebeverine is hydrolyzed to veratric (3.4-dimethoxybenzoic) acid and mebeverine alcohol at alkalotic pH value of medium. It has been shown that mebeverine extraction is necessary to study using HPLC-MS/MS, which will allow to avoid the native mebeverine degradation in chromatograph injector as with GC-MS method analysis.

01 Jan 2024·Forensic Medical Expertise

Development of selective method for identifying mebeverine in hair

Article

Author: Vikman, P S ; Strelova, O Yu ; Grebenyuk, A N ; Balabanova, O L

OBJECTIVETo develop the method for identification of mebeverine and its metabolites in biological materials (urine and hair) for solution of the problem of possible cross-reaction with psychoactive substances during preliminary studies by immunochromatographic method.MATERIAL AND METHODSThe study was carried out using «Mebeverine» tablets (NAO «Severnaya Zvezda», Russia), enzymes, namely trypsin, chymotrypsin and hyaluronidase, papain. The obtained extracts were analyzed using HELC-MS/MS on a modular liquid Nexera XR chromatograph with a tandem LCMS-8050 (Shimadzu) mass spectrometer. Guinea pigs weighing about 500 gr were used in modelling the long-term use of mebeverine. The drug was administered per os, once to 5 guinea pigs at a dosage of 200 mg calculated as an animal weighing 500 gr and daily urine was collected. The wool was collected 30 days after regular administration.RESULTS AND CONCLUSIONThe main mebeverine's metabolites have been determined and native mebeverine and its marker metabolites (mebeverine and veratric acids) have been found in urine while taking this medicine in therapeutic doses for medical purposes. The application of enzymatic hydrolysis of hair method allowed to establish that hair tissue accumulates only a native molecule of mebeverine, therefore, only by results of hair analysis it is possible to conclude, if there was pharmacological use of this medicine or psychoactive substances from the group of phenylalkilamines. The effectiveness of enzymatic hydrolysis by hyaluronidase to isolate mebeverine from hair has been shown.

100 Deals associated with Mebeverine Hydrochloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D04868	Mebeverine Hydrochloride	A03AA04	DB12554

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Gastrospasm	-	-	-
Irritable Bowel Syndrome	-	-	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05175131 (CTgov)	Phase 3	Abdominal Pain \| Irritable Bowel Syndrome	465	Simethicone+Mebeverine (Mebeverine+Simethicone Combination)	dqfyhpkbqt(ncvdfcpeqe) = nrqsioxtmc hupchpuhjc (xzvdvrpwzk, cdpiijafmi - wnslzrqakd) View more	-	03 Jan 2024
				Mebeverine (Mebeverine)	dqfyhpkbqt(ncvdfcpeqe) = twalmqbbco hupchpuhjc (xzvdvrpwzk, sctblmpbhd - catkvwfmbl) View more