Delving into the Latest Updates on AD-0261 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target-

Action-

Mechanism-

Therapeutic Areas

Other Diseases

Active Indication-

Inactive Indication

Inflammation

Originator Organization

Green Cross Co., Ltd.

Active Organization-

Inactive Organization

Green Cross Co., Ltd.

License Organization-

Drug Highest PhasePendingDiscovery

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC27H31F2N3O

InChIKeyNVYQVXULNKIDMV-UHFFFAOYSA-N

CAS Registry145600-69-7

In order to develop novel compounds for topical use possessing antiallergic as well as antiinflammatory activities, a series of o-aminophenol derivatives bearing H1-antihistaminic structures were synthesized and their effects were investigated on lipid peroxidation in rat brain homogenates, antiinflammatory effection arachidonic acid- and 12-O-tetradecanoylphorbol-13- acetate-induced mouse ear edema and antiallergic effect on 48-h homologous passive cutaneous anaphylaxis in rats. Furthermore, the effects of these compounds on delayed-type hypersensitivity reaction in mice were examined. Several N-monosubstituted amino-4-methylphenols were found to exert potent inhibitory activities in all of these assays. Of these compounds, 4m was chosen for further development as AD0261.

Organic Reactions (Hoboken, NJ, United States)

Reductive aminations of carbonyl compounds with borohydride and borane reducing agents

Author: Reitz, Allen B. ; Baxter, Ellen W.

A review of the article Reductive aminations of carbonyl compounds with borohydride and borane reducing agents.

100 Deals associated with AD-0261

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