ABSTRACTIn recent years, transductors of chiral information based on conducting polymers have gained considerable attention. In particular, inherently chiral materials, which allow differentiation between the antipodes of a chiral analyte in terms of energetic variations, are highly desired. In this work, we successfully synthesized a novel inherently chiral oligomer based on an indole–benzothiophene core, namely, 2‐([2,2′‐bithiophen]‐5‐yl)‐3‐(2‐([2,2′‐bithiophen]‐5‐yl)benzo[b]thiophen‐3‐yl)‐N‐methylindole (BTIndT4). The electrochemical characterization evidences a stabilization of electrogenerated radical cations due to the presence of the indole group, which guides the oligomerization, producing well‐ordered polymeric matrices. Furthermore, the in situ electrochemical conductance analysis demonstrates a simultaneous intrachain and interchain transfer of charge carriers. Finally, the highly efficient enantiorecognition capabilities of the antipodes of the oligo‐BTIndT4 films toward the enantiomers of tryptophan and 3,4‐dihydroxyphenylalanine (DOPA), as model chiral analytes, were demonstrated.

13 Mar 2024·ACS Applied Materials & Interfaces

In Situ-Grown 2D Perovskite Based on π-Conjugated Aggregation-Induced Emission Organic Spacer Boosting the Efficiency and Stability of 2D–3D Heterostructured Perovskite Solar Cells

Article

Author: Zhang, Dan ; Zhao, Yixing ; Li, Fan ; Fan, Zhiping ; Xia, Xuefeng ; Wang, Xiaofeng

The two-dimensional-three-dimensional (2D-3D) heterostructured perovskite solar cells (PSCs) have drawn widespread interest, wherein the organic spacer plays a significant role in the photovoltaic performance. Herein, a novel π-conjugated organic spacer with the aggregation-induced emission (AIE) property, (Z)-2-([1,1'-biphenyl]-4-yl)-3-(5-(4-(3-aminopropoxy)phenyl)thiophen-2-yl)acrylonitrile (BPCSA-S), is designed and synthesized, which is successfully applied for the in situ construction of 2D-3D heterostructured PSCs via the two-step solution method. By virtue of the functional groups (i.e., cyano, thiophene, and amino) in BPCSA-S, the BPCSA-S organic spacer can trigger the in situ growth of 2D perovskites, which will serve as the template for the heteroepitaxial growth of 3D perovskites, thus obtaining a 2D-3D heterostructured film with high-quality and few defects. More pleasingly, benefiting from the AIE property and delocalized π-electrons in the π-conjugated BPCSA-S organic spacer, excellent photosensitization process and carrier transport can be achieved. Consequently, the resultant 2D-3D heterostructured PSCs yield a pleasing PCE of 22.07%, accompanied by mitigatory hysteresis, as well as enhanced stability. Our research shows a hopeful multifunctional organic spacer approach using the novel π-conjugated AIE organic spacer for high-performance PSCs.

01 Jan 2024·Research

Aggregation-Induced Emission-Active Photosensitizer-Mediated Photodynamic Therapy for Anti-Psoriasis

Article

Author: Chen, Yinghua ; Li, Junjie ; Liao, Yunhui ; Liu, Yanshan ; Tang, Tingting ; Hu, Guodong ; Wu, Zhaoji ; Yang, Zhilu ; Wu, Zhenzhen ; Huang, Ying ; Zhu, Ping ; Chen, Tao ; Zhao, Wen ; Nong, Chunmei

Hyperproliferative keratinocytes and subcutaneous inflammation contribute to the characteristic symptoms of psoriasis, including erythema, scales, or scaly plaques on the skin. These symptoms significantly affect patients’ quality of life and cause severe physical and psychological distress. However, current treatment strategies have limited therapeutic effect and may lead to adverse side effects. In this study, we present the novel organic photosensitizer TBTDC [5-(((5-(7-(4-(diphenylamino)phenyl)benzo[c][1,2,5]thiadiazol-4-yl)thiophen-2-yl)methylene)amino)-3-methylthiophene-2,4-dicarbonitrile] nanoparticles (NPs) with aggregation-induced emission (AIE) characteristics to mediate photodynamic therapy (TBTDC NP-PDT) for psoriasis treatment. We demonstrate that TBTDC NPs effectively generate reactive oxygen species upon light irradiation and lead to significant apoptosis of psoriatic keratinocytes. Furthermore, TBTDC NPs exhibit high cellular uptake in diseased keratinocytes and induce endoplasmic reticulum stress (ERS)-mediated autophagy, which can also enhance apoptosis. Importantly, TBTDC NPs show no cytotoxicity toward keratinocytes. These unique properties of TBTDC NPs enable remarkable therapeutic effects against psoriasis-like skin lesions and related inflammation in vivo. Overall, our AIE-active TBTDC NP-PDT represents a promising strategy for treating psoriasis in clinical settings.

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Indication	Highest Phase	Country/Location	Organization	Date
Polycystic Kidney, Autosomal Dominant	Preclinical	CN	Shanghai Alebund Pharmaceuticals Co., Ltd.	03 Jan 2024

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