Author: Bianco, Giuliana ; Montoro, Paola ; Rizzi, Vito ; Acquavia, Maria Assunta ; Della Sala, Paolo ; Di Capua, Angela ; Tesoro, Carmen ; Guerrieri, Antonio ; Gaeta, Carmine ; Ciriello, Rosanna ; Iannece, Patrizia ; Cosma, Pinalysa ; Lelario, Filomena ; Gregori, Emanuela ; Gubitosa, Jennifer

This research employs advanced analytical techniques to explore the specific roles of Pomegranate Juice (PJ) phytochemicals in both the reduction and stabilization of gold nanoparticles (AuNPs) obtained by means of juice from wasted fruits. A level 3 for classes annotation, used for MALDI FT ICR-MS data, was useful to provide an immediate visualization of the main involved metabolites in AuNPs synthesis, through van Krevelen diagrams. More than 25 elemental formulae containing at least one Au atom were assigned to AuNPs sample, confirming the formation of organogold complexes. LC-MS/MS analysis allowed a level 2 annotation of polyphenols and carbohydrates involved in metal reduction and AuNPs surface coating. This work highlights the potential of PJ in green nanoparticles synthesis, providing insights into the bioactive compounds responsible for the tunable characteristics of AuNPs.

01 May 2025·Food Chemistry

Optimization of NADES-based green extraction of ellagitannins from rambutan peel with enhanced antioxidant activity

Article

Author: Murughanantham, Nevedita ; Shin, Sung Woo ; Kim, Na Woo ; Kang, Tong Ho ; Seo, Gyeong Jin ; Pandian, Subha ; Nuankaew, Wanlapa ; Ahn, Soo Mi ; Hwang, Jae Sung ; Nam, Youn Hee ; Hong, Bin Na

Rambutan (Nephelium lappaceum L.) peel contains bioactive compounds such as geraniin, corilagin, ellagic acid, and gallic acid, known for their antioxidant, anti-inflammatory, and anticancer properties. Traditional extraction methods involve toxic solvents like methanol and ethanol, posing environmental and safety concerns. This study optimized the extraction of ellagitannins from rambutan peel using Natural Deep Eutectic Solvents (NADES), which are sustainable, non-toxic, and cost-effective. The optimal conditions-water content (20 %), temperature (80 °C), and time (60 min)-were identified using Response Surface Methodology (RSM). The NADES system, composed of betaine (hydrogen bond acceptor) and 1,2-propanediol (donor) in a 1:2 M ratio, achieved the highest ellagitannin yield (54.29 μg/mg) and antioxidant activity (DPPH IC₅₀ = 35.86 μg/mL, ABTS IC₅₀ = 37.66 μg/mL). These findings demonstrate that NADES can be effectively tailored for bioactive compound extraction from rambutan peel, providing a greener alternative for the food, pharmaceutical, and cosmetic industries.

01 Apr 2025·Phytochemical Analysis

An Integrative Strategy for Discriminating Quality Markers of Tibetan Medicine Chebulae Fructus Based on Multidimensional Feature Network

Article

Author: Chen, Juan ; Li, Qian‐Qian

ABSTRACTChebulae Fructus (TCF) is a traditional Chinese medicine and Tibetan medicine with high medicinal value, but its quality control indicators still need clarification. In this study, a strategy was proposed to specify the quality markers (Q‐markers) of TCF by constructing a multidimensional feature network that includes dimensions of effectiveness, content, traceability, and specificity. Network pharmacology analysis was performed to validate the effectiveness of the chemical constituents in TCF through creating a TCF–component–disease–target–pathway network. By combining fingerprints analysis with UPLC‐QTOF‐MS, 17 differential components were identified among 19 batches of TCF samples. Serum pharmacochemical analysis on rats identified seven prototype components absorbed into the blood. The scores for the four dimensions were calculated using these identified components as candidates, and a multidimensional feature network based on the “spider‐web” model was constructed. Ultimately, chebulinic acid, ellagic acid, chebulagic acid, methyl gallate, gallic acid, chebulic acid, and trigalloylglucose were clarified as Q‐markers of TCF. These Q‐markers screened out in this study are closely linked to the efficacy of TCF and can serve as indicator components for quality control of TCF.

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Indication	Highest Phase	Country/Location	Organization	Date
Influenza A virus infection	Preclinical	China	Southern Medical University	13 Dec 2019

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