Last update 21 Feb 2026

mRNA-4203

Overview

Basic Info

Drug Type
mRNA vaccine
Synonyms
mRNA 4203, mRNA4203
Target
PRAME
Action
inhibitors
Mechanism
PRAME inhibitors(PRAME nuclear receptor transcriptional regulator inhibitors)
Therapeutic Areas
NeoplasmsSkin and Musculoskeletal DiseasesOther Diseases
Active Indication
Melanoma, Cutaneous MalignantSynovial SarcomaUnresectable Melanoma
Inactive Indication-
Originator Organization
Moderna, Inc.Moderna, Inc.
Active Organization
ModernaTX, Inc.
Inactive Organization-
License Organization
Immatics NVModerna, Inc.Moderna, Inc.
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with mRNA-4203
NCT06946225
/ RecruitingPhase 1
A First-in-human, Open-label Trial to Evaluate the Combination of ACTengine® IMA203 With mRNA-4203 in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma or Synovial Sarcoma Patients (ACTengine® IMA203-102)
100 Clinical Results associated with mRNA-4203
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100 Translational Medicine associated with mRNA-4203
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100 Patents (Medical) associated with mRNA-4203
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100 Deals associated with mRNA-4203
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Melanoma, Cutaneous MalignantPhase 1
United States
ModernaTX, Inc.
25 Jul 2025
Synovial SarcomaPhase 1
United States
ModernaTX, Inc.
25 Jul 2025
Unresectable MelanomaPhase 1
United States
ModernaTX, Inc.
25 Jul 2025
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Clinical Result

Indication
Phase
Evaluation
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Deal

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Clinical Trial

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Approval

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Regulation

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