AbstractBackgroundSymptomatic premature ventricular complexes (PVCs) are a common clinical problem. Although most of ventricular ectopic foci can be easily ablated, some are very challenging and require special manoeuvers. This case report presents an approach to improve electrode stability during ablation.Case summaryA 19-year-old Asian male patient presented with frequent symptomatic PVCs having an inferior axis, left bundle branch morphology, and R/S transition in V4. Structural heart disease was excluded by echocardiography and general blood tests were normal. The treatment with a class Ic antiarrhythmic (ethacizine) over 2 months was ineffective and the patient was admitted for radiofrequency ablation. Activation mapping revealed a PVC focus in the superior part of the tricuspid annulus, but the femoral access approach resulted in frequent dislocation of the ablation tip. An internal jugular vein approach though resulted in improved stability and successful elimination of the PVC.DiscussionIn cases with PVCs from the superior portions of the right heart, stability of the electrode may be improved by a jugular venous access.

01 Feb 2020·Bulletin of Experimental Biology and MedicineQ4 · MEDICINE

Peculiarities of Pharmacokinetics and Bioavailability of Some Cardiovascular Drugs under Conditions of Antiorthostatic Hypokinesia

Q4 · MEDICINE

Article

Author: Repenkova, L G ; Savelyeva, M I ; Svistunov, A A ; Polyakov, A V ; Kovachevich, I V ; Kukes, V G ; Kondratenko, S N

We studied pharmacokinetics and bioavailability of verapamil, propranolol, and ethacizine in healthy volunteers after single oral administration under normal conditions and on the second day of simulated antiorthostatic hypokinesia modeling some effects of microgravity. Under conditions of antiorthostatic hypokinesia, a tendency to a decrease in half-elimination period, mean retention time, and volume of distribution and an increase in the rate of absorption, ratio of maximum concentrations, and relative rate of absorption of verapamil and propranolol were revealed. For ethacizine, a statistically significant increase in the time of attaining maximum concentration and volume of distribution and a decrease in the maximum concentration, rate of absorption, ratio of maximum concentrations, and relative rate of absorption under conditions of antiorthostatic hypokinesia were found.

01 Jan 2011·KardiologiiaQ4 · MEDICINE

[Appearance of ECG signs of the Brugada syndrome during therapy with class 1C antiarrhythmic drug ethacizine].

Q4 · MEDICINE

Article

Author: Makarov, L M ; Komoliatova, V N

100 Deals associated with Ethacizine

External Link

KEGG	Wiki	ATC	Drug Bank
D10503	Ethacizine	C01BC09	DB13645

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Arrhythmias, Cardiac	-	-	-

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis