Last update 19 Jul 2025

Compound 18(University of Bonn)

Overview

Basic Info

Drug Type
Proteolysis-targeting chimeras (PROTAC)
Synonyms-
Target
CDK4 x CDK6
Action
degraders
Mechanism
CDK4 degraders(Cyclin-dependent kinase 4 degraders), CDK6 degraders(Cyclin-dependent kinase 6 degraders)
Therapeutic Areas
Neoplasms
Active Indication-
Inactive Indication
Neoplasms
Originator Organization
University of BonnUniversity of Bonn
Active Organization-
Inactive Organization
University of BonnUniversity of Bonn
License Organization-
Drug Highest PhasePendingPreclinical
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC55H72N10O10
InChIKeyZKAFGCUKFVTUIZ-UHFFFAOYSA-N
CAS Registry-

Related

100 Clinical Results associated with Compound 18(University of Bonn)
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100 Translational Medicine associated with Compound 18(University of Bonn)
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100 Patents (Medical) associated with Compound 18(University of Bonn)
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1
Literatures (Medical) associated with Compound 18(University of Bonn)
Chemical scienceQ1 · CHEMISTRY
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders
Q1 · CHEMISTRY
100 Deals associated with Compound 18(University of Bonn)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NeoplasmsPreclinical
Germany
University of BonnUniversity of Bonn
01 Jan 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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