A Randomized, Double-blind, Placebo-controlled, Sequential, Adaptive Single Ascending Dose Study to Evaluate the Safety and Tolerability, Pharmacokinetics and Pharmacodynamic Profile of Orally Administered MSD-001 in Healthy Participants.

The purpose of this Phase 1 single ascending dose (SAD) study is to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamic profile of MSD-001 when administered orally to healthy adult participants.

Start Date11 Nov 2024

Sponsor / Collaborator

Mindstate Design Labs, Inc.

100 Clinical Results associated with MSD-001

100 Translational Medicine associated with MSD-001

100 Patents (Medical) associated with MSD-001

Literatures (Medical) associated with MSD-001

01 May 2025·Environmental Pollution

Effects of arsenic and trace metals on bacterial denitrification process from estuarine sediments and associated nitrous oxide emission

Article

Author: Wang, Jun ; Ding, Yu ; Sang, Changpeng ; Huang, Zhangxun ; Peng, Zetao ; Zeng, Xiangfeng ; Wang, Shaofeng ; Jia, Yongfeng ; Li, Haozheng ; Zhu, Xiayu ; Wang, Xinjie ; Li, Yongbin

Coastal ecosystems currently face significant challenges due to nutrient enrichment and trace metal contamination. However, the effects of arsenic (As) and other trace metals (copper, lead, zinc, cadmium, mercury) on denitrification processes and nitrous oxide (N₂O) emissions in estuarine sediments remain poorly understood. Here, we examined the influence of As and other trace metals on denitrification and N₂O emissions in a single denitrifying strain, Marinobacter sp. MSD-1, isolated from metal-contaminated estuarine sediments based on its As(III)-oxidizing and denitrifying abilities and functional microbial composition. The results showed that As did not significantly affect the denitrification or N₂O emission of MSD-1. However, Cd(II) at concentrations of 5-10 mg/L significantly induced the accumulation of N₂O, while not significantly affecting the reduction of nitrate (NO₃^-) and nitrite (NO₂^-). The presence of As(III) further inhibited the N₂O reduction under Cd exposure, but it had no significant effect on the N₂O reduction after exposure to other trace metals. A negative correlation was observed between N₂O reductase (NO₂R) activity and N₂O emissions, indicating that Cd(II) inhibits the reduction process of N₂O mainly by suppressing the activity of NO₂R. This study highlights the detrimental effects of cadmium on microbial denitrification and subsequent emissions of the greenhouse gas N₂O, thereby improving our understanding of how estuarine and coastal ecosystems respond and adapt to trace metal pollution.

100 Deals associated with MSD-001

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Indication	Highest Phase	Country/Location	Organization	Date
Psychotic Disorders	Phase 1	Netherlands	Mindstate Design Labs, Inc.	11 Nov 2024

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