Delving into the Latest Updates on Melatonin oral gel(Spherium Biomed SL) with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Melatonin

+ [2]

Target

Melatonin receptor

Action

agonists

Mechanism

Melatonin receptor agonists

Therapeutic Areas

NeoplasmsMouth and Tooth Diseases

Active Indication

Head and Neck NeoplasmsStomatitis

Inactive Indication

Autism Spectrum Disorder

Originator Organization

Spherium Biomed SL

Active Organization

Spherium Biomed SL

Link Health Group Ltd.

Inactive Organization

Neurim Pharmaceuticals Ltd.

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC13H16N2O2

InChIKeyDRLFMBDRBRZALE-UHFFFAOYSA-N

CAS Registry73-31-4

Author: Dickerson, Broderick L. ; Candow, Darren G. ; Campbell, Bill I. ; Heileson, Jeffery L. ; Tinsley, Grant M. ; Leonard, Megan ; Kerksick, Chad M. ; Cordingley, Dean M. ; Kalman, Douglas S. ; Forbes, Scott C. ; Antonio, Jose ; Cornish, Stephen M. ; Jäger, Ralf ; Cannataro, Roberto ; Kreider, Richard B. ; Stout, Jeffrey R. ; Abou Sawan, Sidney ; Bongiovanni, Tindaro ; Arent, Shawn M.

Position Statement: The International Society of Sports Nutrition (ISSN) presents this position based on a critical examination of the literature surrounding the effects of long-chain omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on exercise performance, recovery, and brain health. This position stand is intended to provide a scientific foundation for athletes, dietitians, trainers, and other practitioners regarding the effects of supplemental ω-3 PUFA in healthy and athletic populations. The following conclusions represent the official position of the ISSN: Athletes may be at a higher risk for ω-3 PUFA insufficiency.Diets rich in ω-3 PUFA, including supplements, are effective strategies for increasing ω-3 PUFA levels.ω-3 PUFA supplementation, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been shown to enhance endurance capacity and cardiovascular function during aerobic-type exercise.ω-3 PUFA supplementation may not confer a muscle hypertrophic benefit in young adults.ω-3 PUFA supplementation in combination with resistance training may improve strength in a dose- and duration-dependent manner.ω-3 PUFA supplementation may decrease subjective measures of muscle soreness following intense exercise.ω-3 PUFA supplementation can positively affect various immune cell responses in athletic populations.Prophylactic ω-3 PUFA supplementation may offer neuroprotective benefits in athletes exposed to repeated head impacts.ω-3 PUFA supplementation is associated with improved sleep quality.ω-3 PUFA are classified as prebiotics; however, studies on the gut microbiome and gut health in athletes are currently lacking.

01 Jun 2025·Journal of Photochemistry and Photobiology A: Chemistry

Ionic liquid-capped silver-zinc oxide@activated carbon: A Powerful nanocomposite for colorimetric uric acid detection

Author: Ullah, Riaz ; Ali, Essam A. ; Zhang, Xiaoping ; Khan, Muslim ; Shah, Mohibullah ; Asad, Muhammad ; Sun, Wei ; Khan, Naeem ; Nishan, Umar ; Badshah, Amir

Abnormal levels of uric acid in the human body lead to several diseases such as gout, diabetes, renal impairment, cardiovascular problems, etc.It is imperative to develop an easy-to-use and low-cost sensing platform.The present work reports on a non-enzymic colorimetric sensor based on the peroxidase-like activity of ionic liquid-capped silver-zinc oxide-doped activated carbon (IL/Ag-ZnO@AC) for the detection of uric acid.The prepared nanocomposite was characterized by various spectroscopic techniques.The prepared nanozyme catalyzed the oxidation of the chromogenic substrate TMB (3,3′,5,5′-tetramethylbenzidine).Based on the redox chem. of uric acid, it inhibited the peroxidase-like activity of the proposed nanozyme with a visible colorimetric change.Subsequently, various parameters such as time, pH, H₂O₂, and the amount of the nanozyme as well as TMB were optimized.The proposed assay showed linear detection of uric acid in the range of 0.5-180 μM.Other parameters, such as the limit of detection, limit of quantification, and R2 were computed to be 0.13 μM, 0.45 μM, and 0.999, resp.Alongside its sensitivity, the developed assay was found to be highly selective in the presence of various potential interfering species.The proposed assay was successfully employed for the detection of uric acid in real samples under optimum exptl. conditions.The proposed nanozyme has the potential to translate into a useful laboratory tool that can routinely be used for the sensing of uric acid in various diseases.

01 May 2025·Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology

Melatonin modulates autophagy, mitochondria and antioxidant in the liver and brain of Perccottus glenni during recovery from freezing

Author: Hu, Tingting ; Ye, Cunrun ; Mu, Weijie ; Ning, Zhaoyang ; Zhao, Xiaoyu

The Amur sleeper (Percottus glenii), a freeze tolerant fish species, can survive being frozen in ice, survival after recovery from freezing.This study investigated the role of melatonin in the recovery of Perccottus glenni following freezing.The fish were categorized into the following groups: non-treated control (Con), pinealectomy (Px), melatonin injection (Mlt), sham control (Sham), and saline injection control (Sal).The results revealed that the melatonin levels were affected by pinealectomy and melatonin injection.The liver and brain of the Px and Mlt groups exhibited autophagy after 4 h, along with the differential expression of endoplasmic reticulum stress-related genes.Furthermore, the activities of the mitochondrial complex initially increased at 4 h and then decreased by 12 h in the Px and Mlt groups, while antioxidant enzyme activities varied across groups and time points.These findings indicated that melatonin plays a key role in the recovery of P. glenni in a time-dependent manner, affecting autophagy, mitochondrial function, and antioxidant capacity.This study is the first to demonstrate melatonin′s time-dependent role in facilitating the recovery of P. glenni after freezing, highlighting its critical involvement in modulating autophagy, mitochondrial function, and antioxidant processes.These findings shed light on the physiol. mechanisms underlying freeze tolerance and recovery in fish, offering valuable insights for understanding and potentially enhancing the recovery processes in other species.

100 Deals associated with Melatonin oral gel(Spherium Biomed SL)

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB01065

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Head and Neck Neoplasms	Phase 2	-	Spherium Biomed SL	-
Head and Neck Neoplasms	Phase 2	-	Link Health Group Ltd.	-
Stomatitis	Phase 2	-	Link Health Group Ltd.	-
Autism Spectrum Disorder	Preclinical	-	Neurim Pharmaceuticals Ltd.	01 Sep 2020